Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo

Young, Sun; Park, Won Sun; Lee, Daesung; Choi, Grace; Yim, Mi‐Jin; Lee, Jeong Min; Jung, Won‐Kyo; Park, Sae Gwang; Seo, Su‐Kil; Park, Sung Jae; Han, Il Yong; Choi, Yung Hyun; Choi, Il‐Whan

doi:10.1016/j.ejphar.2017.06.022

Cited by 25 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunohistochemical analysis of lung biopsy specimens from patients with IPF revealed that fibroblasts within fibrotic foci expressed low levels of PTEN and upregulated levels of AKT (79). Fucoxanthin inhibited the TGF-β1-induced expression of α-SMa, type 1 collagen and il-6, and inhibited the phosphorylation of p38, PI3K/AKT and Smad2/Smad3 in human pulmonary fibroblasts (80). Additionally, small interfering rnas (sirnas) against plasminogen activator inhibitor-1 (Pai-1) reduced the expression of type i and iii collagen and increased the expression of caspase-3 in vivo, as well as inhibiting p-ERK1/2 and PI3K/AKT expression, and induced the proliferation of fibroblasts derived from rat models of BLM-induced fibrosis (81).…”

Section: Discussionmentioning

confidence: 99%

Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

Zhao

et al. 2020

Mol Med Report

View full text Add to dashboard Cite

Baicalin is an important flavonoid compound THaT is isolated from the Scutellaria baicalensis Georgi chinese herb and plays a critical role in anti-oxidative, anti-inflammatory, anti-infection and anti-tumor functions. although baicalin can suppress the proliferation of tumor cells, the underlying mechanisms of baicalin in bleomycin (BLM)-induced pulmonary fibrosis remain to be elucidated. Thus, the aim of the present study was to determine the role of baicalin in pulmonary fibrosis and fibroblast proliferation in rats. Hematoxylin and eosin (H&E) and Masson staining were used to measure the morphology of pulmonary fibrosis, ELIASA kits were used to test the ROS and inflammation, and western blotting and Tunel were performed to study the apoptosis proteins. In vitro, MTT assay, flow cytometry, western blotting and immunofluorescence were performed to investigate the effects of baicalin on proliferation of fibroblasts. The most significantly fibrotic changes were identified in the lungs of model rats at day 28. Baicalin (50 mg/kg) attenuated the degree of pulmonary fibrosis, and the hydroxyproline content of the lung tissues was decreased in the baicalin group, compared with the BLM group. Further investigation revealed that baicalin significantly increased glutathione peroxidase (GSH-px), total-superoxide dismutase (T-Sod) and glutathione (GSH) levels, whilst decreasing that of serum malondialdehyde (MDA). TUNEL-positive cells were significantly decreased in rats treated with baicalin group, compared with the model group. Furthermore, it was found that BLM promoted fibroblasts viability in a dose-dependent manner in vivo, which was restricted following treatment with different concentrations of baicalin. Moreover, BLM promoted the expression levels of cyclin a, d and e, proliferating cell nuclear antigen, phosphorylated (p)-AKT and p-calcium/calmodulin-dependent protein kinase type. BLM also promoted the transition of cells from the G 0 /G 1 phase to the G 2 /M and S phases, and increased the intracellular ca 2+ concentration, which was subsequently suppressed by baicalin. Collectively, the results of the present study suggested that baicalin exerted a suppressive effect on BLM-induced pulmonary fibrosis and fibroblast proliferation.

show abstract

Section: Discussionmentioning

confidence: 99%

Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

Zhao

et al. 2020

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…In Table 3 , it appears that similar patterns are involved both in COPD and in MCI/AD. The same drug, such as fucoxanthin, is useful both against lung fibrosis and neurodegeneration [ 85 , 86 ]. Moreover, Fx may reverse scopolamine-induced impairments of cognition in mice, increasing choline acetyltransferase (ChAT) activity and brain-derived neurotrophic factor (BDNF) expression, and decreasing AChE activity in the brains.…”

Section: Discussionmentioning

confidence: 99%

“…Drug activities and drug mechanisms of action are investigated on cellular and/or in mouse model systems. Every marine bioactive compound is studied in a single disease (COPD or MCI/AD) model [ 66 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ].…”

Section: Mild Cognitive Impairmentmentioning

confidence: 99%

“…Collagen contraction decreased significantly upon Fx treatment. Intraperitoneal injection of Fx in mice inhibits bleomicyn-induced lung fibrosis [ 85 ]. Fx attenuates Aβ oligomer-induced neurotoxicity on SH-SY5Y cells (isolated from a bone marrow biopsy of a neuroblastoma used as “in vitro models” of neuronal function and differentiation) leading neuroprotective effects via regulating PI3K/Akt and ERK pathways [ 86 ].…”

Section: Mild Cognitive Impairmentmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

et al. 2018

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is characterized by long-term airflow limitation. Early-onset COPD in non-smoker subjects is ≥60 years and in the elderly is often associated with different comorbidities. Cognitive impairment is one of the most common feature in patients with COPD, and is associated with COPD severity and comorbidities. Cognitive impairment in COPD enhances the assistance requirement in different aspects of daily living, treatment adherence, and effectual self-management.This review describes various bioactive compounds of natural marine sources that modulate different targets shared by both COPD and cognitive impairment and hypothesizes a possible link between these two syndromes.

show abstract

“…depsipeptide coibamide A (240) [262]; sponge Theonella aff. swinhoei cyclic peptide cyclotheonellazole A (241) [263]; bacterium SNA-024 N 6 ,N 6 -dimethyladenosine (242) [264]; gorgonian Briareum excavatum briarane-type diterpene excavatolide B (150) [265]; brown algae Undaria pinnatifida, Ecklonia stolonifera and/or Sargassum horneri marine carotenoid fucoxanthin (51) [266]; sponge Phorbas sp. diterpenoid gagunin D (243) [267]; bacterium Bacillus sp.…”

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

View full text Add to dashboard Cite

The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

show abstract

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo

Cited by 25 publications

References 36 publications

Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

Baicalin alleviates bleomycin‑induced pulmonary fibrosis and fibroblast proliferation in rats via the PI3K/AKT signaling pathway

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Contact Info

Product

Resources

About