Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

Prinzi, Giulia; Santoro, Alessia; Lamonaca, Palma; Cardaci, Vittorio; Russo, Patrizia

doi:10.3390/md16090313

Cited by 4 publications

(4 citation statements)

References 110 publications

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“…The MMSE for the score range 23.9-30 shows a little better performance for GG (84.62% versus 77.78%), although this test is not the most appropriate instrument to evaluate MCI [45][46][47], and therefore we used in our group of COPD patients also the MoCA that includes executive tests, and allows to identify nonamnestic MCI [48,36], [49][50][51][52]. It has been reported that rs30800373 and rs4713916 are in linkage disequilibrium with rs1360780 thus their effects are supposed to be related to the same mechanism [53].…”

Section: Discussionmentioning

confidence: 99%

FKBP5 Polymorphism, Coping and Emotional Status in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation

Prinzi¹,

Tomino²,

Santoro³

et al. 2019

Preprint

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Background: COPD is characterized by dyspnea, chronic cough, sputum production and extra pulmonary multimorbidity including depression, anxiety and cognitive problems. Methods: Cognitive and psychological clinical alterations/disorders; QoL/Health-related QoL; and Coping strategies were evaluated in 71 COPD patients characterized for FKBP5 gene (rs4713916). Instruments: MMSE, MoCA, ROCF, BDI-II, CES-D, SAS, SF-36, ADL, IADL, SGRQ, MRF 26, CIRS, Brief COPE. Results: Carriers of the rs4713916 polymorphisms (G:A) show better cognitive performances, higher degree of independence in the ADL and IADL, better QoL before and after rehabilitation, no presence of depressive mood and anxiety symptoms, no family history of psychiatric disorder, more ability to cope with stressors by avoiding emotions but demanding emotional support, and lesser use of anti-anxiety, anti-depressant anti-psychotic, hypnotic-sedative drugs. On the other hand, no difference was found as regards the number of comorbidities. Conclusions: Our study shows that rs4713916 is positively associated with better outcome for COPD. These results offer valuable insights into the role of FKBP5 in the complex network of mechanisms associated to clinical and behavioral features of COPD patients.. Our data may be used as initial benchmark for future clinical studies.

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Section: Discussionmentioning

confidence: 99%

FKBP5 Polymorphism, Coping and Emotional Status in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation

Prinzi¹,

Tomino²,

Santoro³

et al. 2019

Preprint

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“…The incidence of COPD in the general population is still increasing, and with an ageing population, this number is expected to increase further. COPD is a multisystem disease, with effects beyond the lung and is associated with symptom burden and prognosis that causes chronic airflow limitation, breathlessness, exercise intolerance, cough, difficulty with daily activities, infections, and (re)hospitalization [2] . COPD has great negative impact on the lives of older people, particularly in relation to quality of life, physical functioning, and increased utilization of health care resources [3] …”

Section: Introductionmentioning

confidence: 99%

“…COPD is a multisystem disease, with effects beyond the lung and is associated with symptom burden and prognosis that causes chronic airflow limitation, breathlessness, exercise intolerance, cough, difficulty with daily activities, infections, and (re)hospitalization. [2] COPD has great negative impact on the lives of older people, particularly in relation to quality of life, physical functioning, and increased utilization of health care resources. [3] Attention and executive dysfunctions are frequent features of mild cognitive impairment (MCI) in COPD.…”

Section: Introductionmentioning

confidence: 99%

Risk of developing cognitive impairment on patients with chronic obstructive pulmonary disease

Simargi¹,

Mansyur²,

Turana³

et al. 2022

Medicine

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Background: The increasing number of chronic obstructive pulmonary disease (COPD) incidence has led to a great negative impact on older people's lives. This chronic disease was a critical and independent risk factor for cognitive function impairment in the elderly with mild cognitive impairment as a frequent feature. This systematic review aimed to examine the risk of developing cognitive impairment in COPD. Methods: A structured search of the literature was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement guideline, with a pre-determined search strategy starting from study identification, title and abstract screening, eligibility assessment, and inclusion of relevant study. The search was conducted in PubMed and MEDLINE via EBSCOhost, with restriction to human studies. The studies from inception until January 12, 2021. Results: Five original articles were included. Most studies found that patients with COPD had a higher chance of developing cognitive impairment, especially when patients were followed up for more than 5 years. We discovered that the risk of cognitive impairment seemed to be correlated with the length of time spent following the participants, with the highest risk of cognitive impairment being identified in those who had the longest observation period. It is critical to conduct cognitive screening from the time a diagnosis of COPD is obtained and on a continuing basis in order to recognize and treat these individuals appropriately. Conclusion: There is a potential association between COPD and mild cognitive impairment. We encourage more studies to be done with higher sensitivity and specificity cognitive screening tools in the future to build better evidence and qualify to be analyzed quantitatively with meta-analysis.

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“…Chronic obstructive pulmonary disease (COPD) is a clinical common chronic respiratory disease characterized by persistent airflow limitation [1][2][3] .Smoking is the most common risk factor for COPD.Smoking inhalation can cause airway pathophysiological changes and then result in airflow limitation. Nevertheless, the mechanism by which smoking provokes the airflow limitation in COPD patients has not been clearly determined, although inflammation [4] , oxidative stress [5] , and protease-antiprotease imbalance [6] have all been proposed to contribute to the development of COPD [7] .…”

Section: Introductionmentioning

confidence: 99%

Neferine Enhances Autophagy to Alleviate Cytotoxicity and Apoptosis Induced by CSE in AEC-II through AMPK/mTOR Signaling Pathway

Wang¹,

Yu²,

Sun³

et al. 2020

Preprint

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COPD is a clinical common chronic respiratory disease, its incidence case fatality rate is higher, there is currently no cure drugs and methods. In this study, in order to make clear its role in the development of autophagy in COPD, COPD cell model is established.To further explore whether regulating autophagy could have a protective effect to fight against CSE-induced cytotoxicity and apoptosis, we choose neferine as an autophagy inducer. Neferine activated cell autophagy in an vitro CSE-induced COPD cell model and gradually attenuated CSE-induced cell apoptosis. Furthermore, this process happens largely through the AMPK/mTOR signaling pathway. As a autophagic flux inhibitor, chloroquine abolished the prosurvival autophagy effect, and AMPK inhibitor Compound C blocked neferine-mediated autophagy and then neferine failed to protect COPD cell model from CSE-induced apoptosis. Overall,our findings suggested that neferine possibly has a potentially protective effect in cell damage mechanisms caused by CSE. It hints that neferine has the prospect of turning into a potential therapeutics to cure CSE-induced cytotoxicity and apoptosis and even COPD patients.

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Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

Cited by 4 publications

References 110 publications

FKBP5 Polymorphism, Coping and Emotional Status in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation

FKBP5 Polymorphism, Coping and Emotional Status in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation

Risk of developing cognitive impairment on patients with chronic obstructive pulmonary disease

Neferine Enhances Autophagy to Alleviate Cytotoxicity and Apoptosis Induced by CSE in AEC-II through AMPK/mTOR Signaling Pathway

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