Fucose-containing bacterial exopolysaccharides: Sources, biological activities, and food applications

Xiao, Mengshi; Ren, Xinmiao; Yu, Ying; Gao, Wei; Zhu, Chunshen; Sun, Han; Kong, Qing; Fu, Xiaodan; Mou, Haijin

doi:10.1016/j.fochx.2022.100233

Cited by 25 publications

(16 citation statements)

References 117 publications

(155 reference statements)

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“…The most reported carbohydrates, other than glucose, included mannose, xylose, galactose, rhamnose, arabinose and fucose [ 94 , 95 ]. The presence of mannose and fucose is an important sign for bioactivity because according to some findings, mannose-rich EPS could stimulate the immune system through macrophage located receptors [ 90 , 96 ]. According to Xiao et al [ 97 ], L-fucose plays a significant role in the anticancer and anti-inflammatory activity of bacterial EPS.…”

Section: Resultsmentioning

confidence: 99%

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor

Angelova

Brazkova

Mihaylova

et al. 2022

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The aim of this study is to characterize the bioactivity of mycelial biomass and crude exopolysaccharides (EPS) produced by Trametes versicolor NBIMCC 8939 and to reveal its nutraceutical potential. The EPS (1.58 g/L) were isolated from a culture broth. The macrofungal biomass was rich in protein, insoluble dietary fibers and glucans. The amino acid composition of the biomass was analyzed and 18 amino acids were detected. Three mycelial biomass extracts were prepared and the highest total polyphenol content (16.11 ± 0.14 mg GAE/g DW) and the total flavonoid content (5.15 ± 0.03 mg QE/g DW) were found in the water extract. The results indicated that the obtained EPS were heteropolysaccharides with glucose as the main building monosaccharide and minor amounts of mannose, xylose, galactose, fucose and glucuronic acid. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the complex structure of the crude EPS. Five probiotic lactic acid bacteria strains were used for the determination of the prebiotic effect of the crude EPS. The anti-inflammatory potential was tested in vitro using cell line HT-29. The significant decrease of IL-1 and IL-8 and increase of TGF-beta expression revealed anti-inflammatory potential of the crude exopolysaccharides from T. versicolor.

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Section: Resultsmentioning

confidence: 99%

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor

Angelova

Brazkova

Mihaylova

et al. 2022

JoF

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“…Fucose-containing polysaccharides (FCPs) and fucose-containing oligosaccharides (FCOs) can be produced through the fermentation of specific bacterial strains, allowing the exploitation of the different structures of fucose-containing exopolysaccharides (FcEPS). Halophilic bacteria have been previously utilized for the production of FcEPS, and evidence on EPS production and biofilm formation among Haloarchaea has also been shown [ 25 , 63 , 64 ]. EPS have many applications in the food industry since they can be exploited as thickeners, emulsifiers, and stabilizers to improve the texture, rheological properties, taste, and appearance of food products [ 63 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Comparative Genomics of Halobacterium salinarum Strains Isolated from Salted Foods Reveals Protechnological Genes for Food Applications

et al. 2023

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Archaeal cell factories are becoming of great interest given their ability to produce a broad range of value-added compounds. Moreover, the Archaea domain often includes extremophilic microorganisms, facilitating their cultivation at the industrial level under nonsterile conditions. Halophilic archaea are studied for their ability to grow in environments with high NaCl concentrations. In this study, nine strains of Halobacterium salinarum were isolated from three different types of salted food, sausage casings, salted codfish, and bacon, and their genomes were sequenced along with the genome of the collection strain CECT 395. A comparative genomic analysis was performed on these newly sequenced genomes and the publicly available ones for a total of 19 H. salinarum strains. We elucidated the presence of unique gene clusters of the species in relation to the different ecological niches of isolation (salted foods, animal hides, and solar saltern sediments). Moreover, genome mining at the single-strain level highlighted the metabolic potential of H. salinarum UC4242, which revealed the presence of different protechnological genes (vitamins and myo-inositol biosynthetic pathways, aroma- and texture-related features, and antimicrobial compounds). Despite the presence of genes of potential concern (e.g., those involved in biogenic amine production), all the food isolates presented archaeocin-related genes (halocin-C8 and sactipeptides).

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“…In contrast, the production of fucose by A. muciniphila has not been observed previously. Fuc-EPS obtained increased attention due to the easily controlled processing procedures, fast and reproducible production and its applications in both food and medicine fields (Xiao et al 2022). Therefore, A. muciniphila EPS may potentially be applied for therapeutic purposes, However, further research on the effect of Akkermansia EPS on host health has yet to be completed.…”

Section: Dietary Polyphenols Were Found To Induce Capsular Polysaccha...mentioning

confidence: 99%

“…Furthermore, the discovery of A. muciniphila fuc-EPS may be another factor in its mechanism to improve host health (Xiao et al 2022) (Figure 2). Therefore, the effect of A. muciniphila fc-EPS on host health should be studied.…”

Section: Concluding Remarks and Future Perspectives On A Muciniphila ...mentioning

confidence: 99%

“…Furthermore, EPS produced by several bacterial species protected the host against the colonization of gut pathogens including Helicobacter pylori (Jones et al 2014, Marcial et al 2017. Lastly, fucose containing-EPS (fuc-EPS) have obtained increased interest in both food and pharmaceutical industries as a promising source of fucose due to their antioxidant, prebiotic, anticancer, anti-inflammatory and antiviral activities (Xiao et al 2022). Since specific EPS structures may be linked to health benefits, it is important to gain knowledge about these bacterial EPS associated with health (Rossi et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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A rising star : A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

Geerlings¹

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General introduction and thesis outlineAkkermansia muciniphila is a fascinating intestinal symbiont, which has received considerable attention over the last two decades due to its mechanisms of action to improve host health. In this thesis, A. muciniphila plays a main role in all the chapters. A. muciniphila Muc T was isolated in 2004 at the laboratory of Microbiology at Wageningen University (Derrien et al. 2004). It is a Gram-negative bacterium belonging to the Verrucomicrobiota (formerly Verrucomicrobia) phylum. In the human gut, A. muciniphila is currently the only representative of this phylum and present in high numbers with an abundance ranging from 0.5-5% (Cani and de Vos 2017). The name A. muciniphila was derived from Dr. Antoon Akkermans, who was leading the Microbial Ecology group within the Laboratory of Microbiology at the time of isolation, shortly before his retirement. The isolation was performed on the fecal sample of a healthy individual using purified mucin as the sole source of carbon, nitrogen, and energy (Derrien et al. 2004, Belzer and de Vos 2012. The genome of A. muciniphila Muc T is composed of one circular chromosome of 2.7 Mbp coding for 2,176 protein-coding genes and is in terms of function mainly dedicated to mucus degradation (van Passel et al. 2011). Here an introduction is provided into the role of A. muciniphila in host health and other functions of this bacterium. In addition, we will introduce different models that may be used to study its performance. A. muciniphila involvement in human healthExtensive studies have been performed on the correlation between the gut microbiota and health and disease (de Vos et al. 2022). The gut microbiota composition was found to be strongly correlated to several diseases, including pre-diabetes, type 2 diabetes, obesity, non-alcoholic fatty liver disease and liver cirrhosis (

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Fucose-containing bacterial exopolysaccharides: Sources, biological activities, and food applications

Cited by 25 publications

References 117 publications

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor

Comparative Genomics of Halobacterium salinarum Strains Isolated from Salted Foods Reveals Protechnological Genes for Food Applications

A rising star : A comprehensive approach to Akkermansia muciniphila ecosystems, interactions and applications

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