Fucoidan from Turbinaria conoides: A multifaceted ‘deliverable’ to combat pancreatic cancer progression

Delma, Caroline R.; Somasundaram, Somasundaram T.; Srinivasan, Guru Prasad; Khursheed,; Bashyam, Murali D.; Aravindan, Natarajan

doi:10.1016/j.ijbiomac.2014.12.031

Cited by 32 publications

(15 citation statements)

References 40 publications

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“…Another study monitored fucoidan antitumor effects on 15 human cancer cell lines. Zymography assays revealed that fucoidan inhibited MMP-2 and -9 activities in pancreatic cancer cells (Delma et al, 2015). The antiproliferative activity of fucoidan from F. vesiculosus on human lymphoma HS-Sultan cell line is induced by apoptosis.…”

Section: Fucoidan Apoptosis and Cell Growth Arrestmentioning

confidence: 94%

Seaweeds in Human Health

Déléris

Nazih

Bard

2016

Seaweed in Health and Disease Prevention

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Section: Fucoidan Apoptosis and Cell Growth Arrestmentioning

confidence: 94%

Seaweeds in Human Health

Déléris

Nazih

Bard

2016

Seaweed in Health and Disease Prevention

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“…Asymmetric and symmetric stretching vibrations of the carboxylic group (-COO-) gave characteristic bands at 1638, 1632, 1611, and 1644 cm −1 and bands at 1423, 1425, and 1422 cm −1 , respectively. It thus proves the acidic nature of polysaccharides and hence the existence of uronic acids [30,31]. The 1365 cm −1 in the FT-IR graph of F 3 fraction, on the other hand, indicated the presence of sulfate groups [32] and 1151 cm −1 indicated hemiacetal stretching [31].…”

Section: Ft-ir Analysis Of Fucoidansmentioning

confidence: 95%

In Vitro Antioxidant and Cytotoxic Properties of Fucoidan From Three Indian Brown Seaweeds

Gopidas

Subramani

2019

Asian J Pharm Clin Res

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Objective: In the present study, fucoidan extracted from three brown algae, Sargassum wightii, Turbinaria ornata, and Padina tetrastromatica, was purified, characterized, and evaluated for antioxidant and cytotoxic properties. Methods: Algal powders were sequentially extracted with five solvents based on polarity and residue was subjected to acidic extraction. The filtrates were precipitated for alginates, and resultant supernatant was precipitated for fucoidan. The precipitate was centrifuged; pellet dialyzed and lyophilized to yield crude fucoidan, which was purified by diethylaminoethyl cellulose chromatography and characterized by biochemical tests and Fourier-transform infrared (FT-IR) spectrometry. Solvent extracts and fucoidans were subjected to 2,2-diphenyl-1-picrylhydrazyl assay. Fucoidans were subjected to trypan blue cytotoxicity assay. Results: Antioxidant activity was highest in methanol extracts and Padina crude fucoidan, while lowest in hexane extracts and purified Sargassum fucoidan. Sargassum yielded the highest amount of fucoidan (7.14%). Total carbohydrates increased as Sargassum> Padina > Turbinaria, sulfates as Padina > Turbinaria > Sargassum, and protein content was 0.16±0.001%. Cytotoxicity increased in a dose-dependent manner; the highest and lowest for Padina at 200 mg mL-1 (40%) and 10 mg mL-1 (4%), respectively. Antioxidant and cytotoxic properties exhibited a positive correlation with sulfate content. FT-IR spectral values were characteristic to fucoidan. Conclusion: Fucoidans from the three algae effectively scavenged free radicals and showed good cytotoxic activity. There was a positive correlation between sulfate content and bioactivity of fucoidans, supporting its structure-function relationship. Thus, extracts and fucoidans from these algae are found to be potential candidates for pharmacological applications.

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“…The effects of fucoidan from the lesser known brown algae, Turbinaria conoides , have been studied in vitro using a specific pancreatic cancer cell line. The research indicated that fucoidan decreased the ability of cancer cells to secrete the matrix-degrading enzymes they required to metastasize and spread [ 72 ]. Interestingly, pancreatic cancer is also highly dependent on CXCR4 to spread.…”

Section: Cancer and Fucoidanmentioning

confidence: 99%

Therapies from Fucoidan: An Update

Fitton¹,

Stringer²,

Karpiniec³

2015

Marine Drugs

328

236

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Fucoidans are a class of sulfated fucose-rich polysaccharides found in brown marine algae and echinoderms. Fucoidans have an attractive array of bioactivities and potential applications including immune modulation, cancer inhibition, and pathogen inhibition. Research into fucoidan has continued to gain pace over the last few years and point towards potential therapeutic or adjunct roles. The source, extraction, characterization and detection of fucoidan is discussed.

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Fucoidan from Turbinaria conoides: A multifaceted ‘deliverable’ to combat pancreatic cancer progression

Cited by 32 publications

References 40 publications

Seaweeds in Human Health

Seaweeds in Human Health

In Vitro Antioxidant and Cytotoxic Properties of Fucoidan From Three Indian Brown Seaweeds

Therapies from Fucoidan: An Update

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