Therapies from Fucoidan: An Update

Fitton, J. Helen; Stringer, Damien N.; Karpiniec, Samuel S.

doi:10.3390/md13095920

Cited by 330 publications

(277 citation statements)

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“…Apart, it has a wealthy source of dietary fiber content with iodine which is play an immense role in enhancing the food quality and biochemical homeostasis [8]. Hence, the cytotoxicity of T. conoides was reported in ethyl acetate extract due to its oxygenated fucosterols [9,10]. Consecutive extraction of T. conoides with n-hexane, cyclohexane, methanol and ethanol: water (1:1) were also documented with their antibacterial and antifungal activities by disc diffusion method.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

et al. 2017

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Background: Cancer causes leading death in the world population due to exposure of various carcinogenic/mutagenic agents, radiation and life style. There are 2.6 million new cases diagnosed each year. Therefore, the objective is aimed to study the antibacterial and antioxidant activities of solvent fractions of ethanolic extract of T. conoides and its anticancer activity also evaluated by analyzing cytotoxicity, cell cycle arrest and apoptosis in HepG2 cell line. Methods: Antibacterial activity was done by disc diffusion method and expressed as in millimeter diameter of zone inhibition. Antioxidant activity was done by ABTS radical assay, superoxide radical assay, iron chelation and uric acid formation inhibitory assays. The cytotoxicity efficacy was estimated using MTT assay. Annexin-V FITC kit was used to estimate the apoptosis and cell cycle arrest by flowcytometer. Morphological changes of cell through alteration of nuclear content and mitochondrial membrane potential were also examined using Hoechst and JC1 stains under fluorescence microscopy, respectively. Results: Highest antibacterial activity, TAA and RAA were found in EAF followed by DMF, HF and AF. Cytotoxicity of EAF was found to be 67% at 24 h and 83% at 48 h over the standard of quercetin (86% at 48 h). The cancer cells were found to be significantly (p < 0.05) higher in the proliferative G0/G1 phase where as significantly decreased in the S phase. Hence, treatment with T. conoides fraction showed statistically (p < 0.05) significant increase of apoptotic cells than that of quercetin standard (32%, 80 μg/mL). The apoptotic cell formation might be due to the change of nuclear content and mitochondrial membrane potential were further confirmed in HepG2 cells under fluorescence microscopy. Conclusion: Ethyl acetate fraction of T. conoides showed highest antibacterial, antioxidant and anticancer activity through exhibiting synergistic effects over the respective standard compounds.

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Section: Introductionmentioning

confidence: 99%

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

et al. 2017

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“…Fucoidans have antiviral activity against several viruses: hepatitis C virus, influence virus, Newcastle disease virus, tick-bone encephalitis virus, Dengue virus, hemorrhagic fever with renal syndrome virus, and viruses of the Herpesviridae family (Fitton, 2011;Fitton et al, 2015).…”

Section: Antiviral Activitymentioning

confidence: 99%

“…For example, 16 fractions of fucoidans with different contents of 1,3-and 1,4-α-L-fucose residues and degrees of sulfation and acetylation were obtained from commercially available fucoidans from F. vesiculosus, which is widely used for the study of biological activities of polysaccharides (Honya et al, 1999;Ale et al, 2011;Fitton, 2011;Fitton et al, 2015). We developed a scheme to purify water-soluble polysaccharides from brown algae and to obtain the fraction of fucoidan from F. evanescens with other structural characteristics compared to those of the fucoidan mentioned above (Bilan et al, 2002).…”

Section: Structure Of Fucoidans From Fucus Evanescensmentioning

confidence: 99%

Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity

et al. 2016

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“…Fucoidan, or sulfated fucan, is a complex sulfated polysaccharide mainly containing L-fucose and is found in brown seaweeds, marine invertebrates (such as sea cucumbers and sea urchins) [1], and recently in seagrasses [2]. In seaweeds, fucoidans are found in the cell-wall matrix whereas they are found in the egg jelly coat of sea urchins and in the body wall of sea cucumbers [3].…”

Section: Fucoidanmentioning

confidence: 99%

“…In seaweeds, fucoidans are found in the cell-wall matrix whereas they are found in the egg jelly coat of sea urchins and in the body wall of sea cucumbers [3]. Fucoidan has been extensively studied due to its many interesting biological properties such as being anticoagulant, antithrombotic, antiviral, anticancer, and anti-inflammatory [1,2,4]. Moreover, fucoidan has shown to be antioxidative and anticomplementary [1] and to provide cardio-, neuro-and gastric protection [4].…”

Section: Fucoidanmentioning

confidence: 99%

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

Tengdelius¹

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Cover: 3D models of three different fucoidan-mimetic glycopolymers Linköping Studies in Science and Technology Dissertations No. 1743 Printed by LiU-Tryck, Linköping, Sweden, 2016 Till morfar som inspirerade mig att börja och Lina och Theo som inspirerar mig att fortsätta. Mattias Tengdelius Fucoidan-Mimetic Glycopolymers -Synthesis and Biomedical Applications I AbstractThe marine polysaccharide fucoidan has demonstrated several interesting biological properties, for instance being antiviral, anticoagulant, anti-inflammatory, anticancer, and platelet activating. Many of these properties are desirable for various biomedical applications. Yet, there are few reports on fucoidan being used in such applications. The reasons for this are primarily the heterogeneity and low structural reproducibility of fucoidan.This thesis describes the synthesis of polymers with pendant saccharides bearing the key structural features of fucoidan. These glycopolymers were synthesized via different radical polymerization techniques yielding polymers of different chain lengths and dispersity. These glycopolymers showed antiviral and platelet activating properties similar to those of natural fucoidan, thus making them fucoidan-mimetic glycopolymers. However, compared to fucoidan from natural sources, the fucoidan-mimetic glycopolymers had homogeneous and reproducible structures making them suitable for biomedical applications.Further studies demonstrated that platelet activation, caused by these glycopolymers, showed dose-response curves almost identical to fucoidan. The platelet activation was induced via intracellular signaling and caused platelet surface changes similar to those of fucoidan. Fucoidan-mimetic glycopolymers can therefore be used as unique biomolecular tools for studying the molecular and cellular responses of human platelets.Fucoidan-mimetic glycopolymers generally assert their antiviral activity by blocking viral entry to host cells, thus inhibiting spreading of the viral infection but not acting virucidal, i.e. not killing the viruses. Introduction of hydrophobic groups to the polymer's chain ends improved the antiviral properties significantly and is an important step towards yielding glycopolymers with virucidal properties.The fucoidan-mimetic glycopolymers were also applied as capping agents when synthesizing gold nanoparticles. These fucoidan-mimetic glycopolymer coated gold nanoparticles showed improved colloidal stability compared to uncapped gold nanoparticles. Furthermore, the nanoparticles also demonstrated selective cytotoxicity against a human colon cancer cell line over fibroblast cells. III Populärvetenskaplig SammanfattningSedan urminnes tider har människan vänt sig till naturen för att bota sjukdomar och andra krämpor. Genom extrakt från framförallt växter har bland annat feber, inflammationer och olika infektioner behandlats långt innan läkemedelskonsten utvecklades till vad den är idag. Även när den moderna läkemedelsvetenskapen, farmakologin, började utvecklas var det naturen som var den främst...

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Therapies from Fucoidan: An Update

Cited by 330 publications

References 123 publications

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

Antibacterial, antioxidant and anticancer properties of Turbinaria conoides (J. Agardh) Kuetz

Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

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