Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori

Abstract

Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. H. pylori, however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the H. pylori treatment. We report here that the fucoidan from Sargassum hemiphyllum can significantly reduce the infection of H. pylori without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit H. pylori adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of H. pylori significantly lowering the total count of H. pylori and the level of IL-6 and TNF-α in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the H. pylori infection by reducing both the total count and induced inflammation.

Fucoidan from Saccharina japonica Alleviates Hyperuricemia-Induced Renal Fibrosis through Inhibiting the JAK2/STAT3 Signaling Pathway

“…Our previous study has shown folic acid competitively binds to the UA-binding pocket through the interaction with amino acid residues of GLUT9 (Trp302) and URAT (Phe91, Trp96, Trp120, Val121, His124, and Arg477) and then directly inhibits their activities Helicobacter pylori, thereby inhibiting its adhesiveness progression with the gastric mucosa . Hence, the interaction of amino acid residues of URAT1 and GLUT9 with fucoidan is of concern and merits further study.…”

“…61 L-Fucose and sulfate in fucoidan have been found to bind the specific amino acid residues on Helicobacter pylori, thereby inhibiting its adhesiveness progression with the gastric mucosa. 62 Hence, the interaction of amino acid residues of URAT1 and GLUT9 with fucoidan is of concern and merits further study. Allopurinol is a U.S. FDAapproved medication to remarkably treat HUA by inhibiting the activity of the xanthine oxidase response for UA formation; therefore, it was used as the positive treatment control in this study.…”

Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection

“…The flavonoid compounds (baicalin and baicalein) mainly found in medicinal plants have anti-inflammatory properties[ 41 ]. Chen et al [ 12 ] revealed that baicalin and baicalein both suppressed the expression of the VacA gene in H. pylori and interfered with the growth and virulence of H. pylori . These herbs also decreased H. pylori -induced expression of interleukin-8[ 42 ].…”

“…However, it has been well established that eradicating H. pylori is challenging[ 11 ]. The main treatment for H. pylori infection is antibiotics, usually the combination of two types of antibiotics in conjunction with a proton pump inhibitor[ 12 ]. Antibiotic resistance of H. pylori is increasing due to the extensive use (or abuse) of antibiotics as the leading cause of treatment failure[ 13 , 14 ].…”

Single-atom-anchored microsweepers for H. pylori inhibition through dynamically navigated reciprocating locomotion

“…1a). 24,25 MGNs (approximately 10 nm) with FeCo cores and protective graphitic shells are used for magnetic propulsion in gastric media due to their excellent magnetic properties and stability (Fig. S2, ESI†).…”