Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase

Daub, Chantal Désirée; Mabate, Blessing; Malgas, Samkelo; Pletschke, Brett I.

doi:10.1016/j.ijbiomac.2020.02.161

Cited by 61 publications

(33 citation statements)

References 27 publications

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“…E. maxima is rich in bioactive compounds such as phlorotannins, steroids, and polysaccharides [38][39][40]. Especially, E. maxima has been reported to contain a high amount of polysaccharides [23]. In the present study, we prepared polysaccharides from E. maxima through Celluclast-assisted extraction and ethanol precipitation and evaluated the antioxidant, anti-melanogenesis, and UV protective effects of the polysaccharides to explore their potential in cosmetics.…”

Section: Chemical Compositionmentioning

confidence: 98%

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The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

et al. 2020

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Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.

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Section: Chemical Compositionmentioning

confidence: 98%

“…Ecklonia maxima is a brown seaweed typically found along the southern Atlantic coast of Africa. Polysaccharides from E. maxima have been reported to have anti-diabetes, anticancer, and antioxidant activities [22][23][24]. However, the cosmeceutical potential of polysaccharides isolated from E. maxima has not been evaluated so far.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

et al. 2020

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“…Fucoidan isolated from S. fusiforme controlled the blood glucose level, recovered liver function, and inhibited oxidative stress in STZ-induced diabetic rats [133]. Fucoidan from Ecklonia maxima acted as a potent α-glucosidase inhibitor with a very low IC 50 value (0.27-0.31 mg/mL) and regulated type II diabetes [134]. Fucoidan from Fucus vesiculosus displayed a robust α-glucosidase inhibitor in diabetes treatment [135].…”

Section: Significance Of Marine Algal Bioactive Metabolites As Anti-dmentioning

confidence: 99%

Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

et al. 2020

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In addition to cancer and diabetes, inflammatory and ROS-related diseases represent one of the major health problems worldwide. Currently, several synthetic drugs are used to reduce oxidative stress; nevertheless, these approaches often have side effects. Therefore, to overcome these issues, the search for alternative therapies has gained importance in recent times. Natural bioactive compounds have represented, and they still do, an important source of drugs with high therapeutic efficacy. In the “synthetic” era, terrestrial and aquatic photosynthetic organisms have been shown to be an essential source of natural compounds, some of which might play a leading role in pharmaceutical drug development. Marine organisms constitute nearly half of the worldwide biodiversity. In the marine environment, algae, seaweeds, and seagrasses are the first reported sources of marine natural products for discovering novel pharmacophores. The algal bioactive compounds are a potential source of novel antioxidant and anticancer (through modulation of the cell cycle, metastasis, and apoptosis) compounds. Secondary metabolites in marine Algae, such as phenolic acids, flavonoids, and tannins, could have great therapeutic implications against several diseases. In this context, this review focuses on the diversity of functional compounds extracted from algae and their potential beneficial effects in fighting cancer, diabetes, and inflammatory diseases.

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“…Studies have shown that the activity of fucoidan increases with the degree of sulphation [32]. Studies have shown that fucoidans have a variety of physiological functions, such as lipid-lowering, anti-tumor [33], anti-virus [34], anti-aging [35], immune regulation [36], hypoglycemic activities [37], and so on. Fucoidans are a series of complex sulphated polysaccharides existing in the cell walls of large brown algae.…”

Section: Fucoidanmentioning

confidence: 99%

“…Studies have shown that the activity of fucoidan increases with the degree of sulphation [32]. Studies have shown that fucoidans have a variety of physiological functions, such as lipidlowering, anti-tumor [33], anti-virus [34], anti-aging [35], immune regulation [36], hypoglycemic activities [37], and so on. Researchers have recently discovered that fucoidan A3, extracted from the brown algae Ascophyllum nodosum significantly reduces the blood serum levels of TC, TG and the fat pad index in hyperlipidemic mice [38].…”

Section: Fucoidanmentioning

confidence: 99%

Advances in the Study of Marine Products with Lipid-Lowering Properties

et al. 2020

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With twice the number of cancer’s deaths, cardiovascular diseases have become the leading cause of death worldwide. Atherosclerosis, in particular, is a progressive, chronic inflammatory cardiovascular disease caused by persistent damage to blood vessels due to elevated cholesterol levels and hyperlipidemia. This condition is characterized by an increase in serum cholesterol, triglycerides, and low-density lipoprotein, and a decrease in high-density lipoprotein. Although existing therapies with hypolipidemic effects can improve the living standards of patients with cardiovascular diseases, the drugs currently used in clinical practice have certain side effects, which insists on the need for the development of new types of drugs with lipid-lowering effects. Some marine-derived substances have proven hypolipidemic activities with fewer side effects and stand as a good alternative for drug development. Recently, there have been thousands of studies on substances with lipid-lowering properties of marine origin, and some are already implemented in clinical practice. Here, we summarize the active components of marine-derived products having a hypolipidemic effect. These active constituents according to their source are divided into algal, animal, plant and microbial and contribute to the development and utilization of marine medicinal products with hypolipidemic effects.

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Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase

Cited by 61 publications

References 27 publications

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review

Advances in the Study of Marine Products with Lipid-Lowering Properties

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