Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy

Jafari, Mina; Sriram, Vishnu; Xu, Zhenyuan; Harris, Greg M.; Lee, Joo-Youp

doi:10.1016/j.carbpol.2020.116837

Cited by 60 publications

(22 citation statements)

References 59 publications

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“…As a natural polysaccharide extracted from brown algae, fucoidan was proved to have many biological effects (12)(13)(14)(15)(16). The anti-tumor abilities of fucoidan were confirmed in pancreatic cancer, bladder cancer, ovarian cancer and other types of cancers (65)(66)(67)(68). Fucoidan could inhibit the occurrence and development of tumor by regulating tumor immunity (21,22), inhibiting angiogenesis (23), interfering with cell cycle and apoptosis (19,20), which is considered to have a broad prospect in the field of tumor therapy.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

Wei

Chen

et al. 2021

Front. Oncol.

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Hepatocellular carcinoma (HCC) as a main type of primary liver cancers has become one of the most deadly tumors because of its high morbidity and poor prognosis. Fucoidan is a family of natural, heparin-like sulfated polysaccharides extracted from brown algae. It is not only a widely used dietary supplement, but also participates in many biological activities, such as anti-oxidation, anti-inflammation and anti-tumor. However, the mechanism of fucoidan induced inhibition of HCC is elusive. In our study, we demonstrated that fucoidan contributes to inhibiting cell proliferation in vivo and in vitro, restraining cell motility and invasion and inducing cell cycle arrest and apoptosis. According to High-Throughput sequencing of long-non-coding RNA (lncRNA) in MHCC-97H cells treated with 0.5 mg/mL fucoidan, we found that 56 and 49 lncRNAs were correspondingly up- and down-regulated. LINC00261, which was related to the progression of tumor, was highly expressed in fucoidan treated MHCC-97H cells. Moreover, knocking down LINC00261 promoted cell proliferation by promoting the expression level of miR-522-3p, which further decreased the expression level of downstream SFRP2. Taken together, our results verified that fucoidan effectively inhibits the progression of HCC via causing lncRNA LINC00261 overexpression.

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Section: Discussionmentioning

confidence: 99%

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

Wei

Chen

et al. 2021

Front. Oncol.

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“…In addition, there are also reports that graft drug molecules on the polysaccharide backbone to achieve drug delivery. As illustrated in Figure 6 a, Jafari et al reported a fucoidan ( M W ~70 kDa)-based DDS for minimizing the side effects of doxorubicin (Dox) with the help of active targeting toward P-selectin [ 84 ]. P-selectin, which plays an important role in metastasis by enhancing the adhesion of cancer cells to endothelium and activated platelets in distant organs, is overexpressed on many cancer types.…”

Section: Preparation and Modification Of The Marine Polysaccharide-based Ddsmentioning

confidence: 99%

“… ( a ) Synthesis route of fucoidan-doxorubicin conjugate (FU-Dox NPs) developed by direct conjugation of Dox to the fucoidan backbone; ( b ) flow cytometry analysis of the cellular uptake of FU-Dox NPs after pretreatment with 1 μM P-selectin inhibitor, KF 38789, for MDA-MB-231 and MDA-MB-468 cell lines. Adapted from [ 84 ]. …”

Section: Figurementioning

confidence: 99%

Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

Sun

Ma²,

2021

Marine Drugs

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Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sensors. The drug delivery system (DDS) can comprehensively control the distribution of drugs in the organism in space, time, and dosage, thereby increasing the utilization efficiency of drugs, reducing costs, and reducing toxic side effects. The nano-drug delivery system (NDDS), due to its small size, can function at the subcellular level in vivo. The marine polysaccharide-based DDS combines the advantages of polysaccharide materials and nanotechnology, and is suitable as a carrier for different pharmaceutical preparations. This review summarizes the advantages and drawbacks of using marine polysaccharides to construct the NDDS and describes the preparation methods and modification strategies of marine polysaccharide-based nanocarriers.

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“…[ 56 ] Also, fucoidan displays a strong affinity to P‐selectin, which is critical to the adhesion of cancer cells to the vascular endothelium and platelets. [ 57 ] Due to its unique biological functions, fucoidan has been investigated for developing scaffolds for various delivery purposes. However, the sugar composition, the sulfate content, and the molecular weight of naturally derived fucoidans are highly heterogeneous, [ 58 ] which present potential challenges in elucidating the structure‐function relationship of the polysaccharide as well as its application as a material candidate for fabricating drug delivery systems.…”

Section: Natural Polysaccharidesmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy

Cited by 60 publications

References 59 publications

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

Fucoidan Inhibits the Progression of Hepatocellular Carcinoma via Causing lncRNA LINC00261 Overexpression

Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

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