Fuchs' heterochromic uveitis and sarcoidosis.

Goble, R R; Murray, Philip I.

doi:10.1136/bjo.79.11.1021

Cited by 14 publications

(8 citation statements)

References 13 publications

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“…Goble & Murray (1995) reported five cases in which there was a possible connection between FHU and sarcoidosis. In our material, we found one patient with probable sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Fuchs' heterochromic uveitis: a longitudinal clinical study

Norrsell

Sjödell

2008

Acta Ophthalmologica

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ABSTRACT.Purpose: To carry out a longitudinal study of patients with Fuchs' heterochromic uveitis (FHU) in western Sweden and to establish the factors responsible for diagnostic delay. Methods: A sample of 54 patients, 51 with monocular and three with binocular FHU, were followed for periods ranging from 8 months to 15 years. Firm diagnostic criteria were set. A detailed anamnesis regarding ocular and extraocular symptoms was taken. The eyes were repeatedly examined. Toxoplasma serology was analysed. Complications were noted. Results: The delay between the first visit to an ophthalmologist and diagnosis was 0)26 years. The most common first symptom was floaters. Iris heterochromia was absent in 11 patients and discrete in 26. Iris atrophy (a diagnostic criterion) was easy to miss. Chorioretinal scars were found in six patients. Toxoplasma serology was positive in 18 (35%) patients. The only serious complication was glaucoma. Conclusions: The most important reason for delay in diagnosis of FHU is, in our opinion, failure to consider the disease as a diagnosis. This failure may occur because heterochromia is often missing or discrete, iris atrophy is easily overlooked, and vitreous opacities are common, often cause early symptoms and can explain prolonged workup and therapy. A connection with toxoplasmosis in individual cases cannot be excluded but toxoplasmosis cannot be considered a major aetiological factor. If detailed anamnesis is negative and diagnostic criteria are fulfilled, no further workup is required.

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“…Goble & Murray (1995) reported five cases in which there was a possible connection between FHU and sarcoidosis. In our material, we found one patient with probable sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Fuchs' heterochromic uveitis: a longitudinal clinical study

Norrsell

Sjödell

2008

Acta Ophthalmologica

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“…Whether this association is a coincidence is a speculation. Goble and Murray [6] have described a case series of association of FHI with sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

“…Previous associations with toxoplasmosis [3], toxocariasis [4,5], sarcoidosis [6], rubella vaccination [7], cytomegalovirus [8,9], herpes simplex virus [10], chikungunya virus infections [11,12], retinitis pigmentosa [13], Horner’s syndrome [14], Usher’s syndrome, and previous trauma [15] have been described in the literature. The purpose of this study is to look at any possible known associations in consecutive cases of FHI in a South Indian patient population.…”

Section: Introductionmentioning

confidence: 99%

Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population

Babu¹,

Adiga²,

Govekar³

et al. 2013

J OPHTH INFLAMM INFECT

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BackgroundThe purpose of this study is to look for any possible associations in 58 consecutive cases of Fuchs heterochromic iridocyclitis (FHI) in a South Indian patient population. Fifty-eight consecutive cases (59 eyes) of FHI underwent a detailed ocular and systemic evaluation. Routine laboratory investigations for uveitis including serum angiotensin-converting enzyme and enzyme-linked immunosorbent assay (ELISA) for toxoplasmosis (IgG and IgM) were done in all the cases. Syndrome Evaluation System comprising of multiplex nucleic acid amplification and signature specific hybridization on the aqueous fluid was done in all 59 eyes for herpes simplex virus (HSV), varicella zoster virus, cytomegalovirus (CMV), rubella virus, chikungunya virus, Toxoplasma, and Mycobacterium tuberculosis. The results were statistically assessed using the SPSS (version 15) package.ResultsThirty-three males and 25 females with FHI were included in the study. Systemic sarcoidosis was seen in two cases. Serological tests failed to confirm an association with toxoplasmosis in all the cases. Aqueous fluid analysis showed positivity only to HSV (one case), CMV (one case), and chikungunya virus (one case).ConclusionsWe do see associations of sarcoidosis, HSV, and CMV in FHI in our patient populations as well. The detection of chikungunya virus in a patient with FHI in our series adds to the list of associations with FHI.

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“…It is an uncommon condition, with estimates of incidence of about 0.2 (per 100,000) in the general population [1,2] and ranging between 1.5% to 4.5% of uveitis cases [3,4]. It has been described in association with multiple diseases including retinitis pigmentosa (RP) [5][6][7][8]. Development of FHU in patients with RP is uncommon, and since the first case was described by Winkler in 1940 [9] only 14 additional cases have been reported [3,[10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%