Fu instant tea ameliorates fatty liver by improving microbiota dysbiosis and elevating short-chain fatty acids in the intestine of mice fed a high-fat diet

Yang, Fan; Feng, Bo; Niu, Yong; Hu, Ching Yuan; Meng, Yong Hong

doi:10.1016/j.fbio.2021.101207

Cited by 16 publications

(18 citation statements)

References 39 publications

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“…Proteobacteria is a marker for an unstable microbial community (dysbiosis) and a potential diagnostic criterion for disease (67), which was significantly decreased by out treatment. As expected, the HFD-induced increase in F/B ratio was visibly counteracted by IDT treatment (Table 2), which is similar to the results obtained from Fu instant tea and Fu brick tea (20,32). What is more, IDT dramatically modified the gut microbial species at the genus level with the decrease of Clostridiales, Ruminococcaceae_UCG-005, Ruminococcus_1, Ruminococcaceae_UCG-014, Lachnospiraceae, and Lachnospiraceae_UCG-010 and a significant increase in beneficial bacteria Akkermansia and Rikenellaceae_RC9_gut_group.…”

Section: Discussionsupporting

confidence: 86%

“…Dark tea as a particular drink significantly affects the lipid metabolism, which shows antiobesity effects. IDT is a new tea product that conforms to the fast-paced life in modern society as easy to drink, exerting higher antioxidant activity compared to normal dark tea extract, which also approved to contain higher content of bioactive compounds such as polysaccharides, polyphenols, and caffeine (32). Tea polysaccharides are considered as the main bioactive ingredients in tea, modulating the metabolic disease including antioxidant and antiinflammatory effects, inhibition of digestive enzymes, prevention of macronutrient absorption, expression of gene and protein, and also interaction with gut microbiota (33).…”

Section: Discussionmentioning

confidence: 99%

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Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

Qin

Yuanjie³

et al. 2022

Front. Nutr.

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Instant dark tea (IDT) is a new product gaining increasing attention because it is convenient and can endow significant health benefit to consumers, which is partially attributed to its high concentration of functional ingredients. However, the molecular mechanism underlying its regulatory effect on hyperlipidaemia is rarely studied. In this study, we performed omics and molecular verification in high-fat diet (HFD)-fed rat, aiming to reveal the mechanism and provide molecular evidence. The results showed that the major bioactive components in IDT were 237.9 mg/g total polysaccharides, 336.6 mg/g total polyphenols, and 46.9 mg/g EGCG. Rats fed with IDT (0.27–0.54 g/kg for 12 weeks) significantly reduced the body weight and TC, TG, LDL-C, blood glucose, and MDA and induced the level of serum HDL-C and also the levels of liver SOD, CAT, GSH-Px, and Nrf2, compared to HFD group. For molecular mechanism study, HIDT feeding had significant impact on the gene expressions of biomarkers in lipogenesis (FABP, CD36, SCD1, Cyp4a1, and Kcnn2), lipid oxidation (PPARγ), and glucose glycolysis (Gck and ENO2) in liver tissue. Moreover, gut microbiome study found that rats fed with IDT dramatically modified the gut microbial species at the family level, such as suppressing the increase abundance of Proteobacteria and Firmicutes induced by HFD. HIDT significantly boosted the relative composition of beneficial bacterium Akkermansia and Rikenellaceae_RC9_gut_group and decreased the relative abundance of the harmful bacterium Ruminococcaceae_UCG-005 and Ruminiclostridium_9, compared to HFD (p < 0.01). Correlation analysis between microbiome and animal indicators found that seven genera including Akkermansia, Clostridiales, Lachnospiraceae, Lachnospiraceae_UCG-010, Ruminiclostridium_9, Ruminococaceae-UCG-005, and Ruminocuccus_1 were found as potential biomarkers that were strongly correlated with oxidative stress and metabolism genes. For instance, Ruminococcaceae_UCG-005 was significantly correlated with body weight, TG, HDL-C, Nfr2, FABP3, SCD1, Cyp4a1, and Kcnn2. Collectively, the above data obtained in this study had provided the primary molecular evidence for the molecular mechanism and brought in novel insights based on omics for the regulatory effect of IDT on hyperlipidaemia.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

Qin

Yuanjie³

et al. 2022

Front. Nutr.

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“…Another study suggested that SCFAs could inhibit hepatic steatosis by activating AMPK and PPAR signaling pathways and down-regulating the expression of genes related to lipid synthesis, such as sterol-regulatory element-binding protein 1 ( SREBP-1 ), FAS , stearoyl-CoA desaturase 1 ( SCD1 ), ACC1 , and liver X receptor ( LXR ) [ 59 ]. Furthermore, pectin, Jaboticaba berry peel, and fu instant tea could alleviate fatty liver disease by regulating intestinal SCFAs [ 60 , 61 , 62 ]. As for drug- or pollutant-induced liver injury, SCFAs also exerted hepatoprotective effects.…”

Section: The Bioactivities Of Scfasmentioning

confidence: 99%

Health Benefits and Side Effects of Short-Chain Fatty Acids

Xiong

Zhou

et al. 2022

Foods

133

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The gut microbiota and their metabolites could play an important role in health and diseases of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome fermentation of dietary fiber and could also be produced by bacteria of the skin and vagina. Acetate, propionate, and butyrate are three major SCFAs, and their bioactivities have been widely studied. The SCFAs have many health benefits, such as anti-inflammatory, immunoregulatory, anti-obesity, anti-diabetes, anticancer, cardiovascular protective, hepatoprotective, and neuroprotective activities. This paper summarizes health benefits and side effects of SCFAs with a special attention paid to the mechanisms of action. This paper provides better support for people eating dietary fiber as well as ways for dietary fiber to be developed into functional food to prevent diseases.

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“…TP has a regulatory effect on intestinal flora and influences the production of intestinal microbial metabolites, including SCFAs, lipopolysaccharides (LPS), and secondary bile acids. Through extensive animal experiments, the researchers found that the content of SCFAs in the intestine of animals treated with TP would be increased, and this phenomenon led to some new thoughts [ 52 , 59 ]. Ding et al [ 60 ] found that six-brewed tea extract increased the abundance of several microorganisms that may produce SCFAs in the intestine of mice, including Lactobacillus , Bacteroides , and Ruminococcaceae , and this finding could provide a solid basis for the increased content of SCFAs in the intestine of animals treated with TP.…”

Section: The Relationship Between Natural Antioxidant Tp and Intestin...mentioning

confidence: 99%

Tea Polyphenols: A Natural Antioxidant Regulates Gut Flora to Protect the Intestinal Mucosa and Prevent Chronic Diseases

Wang

Liu

et al. 2022

Antioxidants

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The intestinal tract of a healthy human body hosts many microorganisms that are closely linked to all aspects of people’s lives. The impact of intestinal flora on host health is no longer limited to the gut but can also affect every organ in the body through various pathways. Studies have found that intestinal flora can be altered by external factors, which provides new ideas for treating some diseases. Tea polyphenols (TP), a general term for polyphenols in tea, are widely used as a natural antioxidant in various bioactive foods. In recent years, with the progress of research, there have been many experiments that provide strong evidence for the ability of TP to regulate intestinal flora. However, there are very few studies on the use of TP to modify the composition of intestinal microorganisms to maintain health or treat related diseases, and this area has not received sufficient attention. In this review, we outline the mechanisms by which TP regulates intestinal flora and the essential role in maintaining suitable health. In addition, we highlighted the protective effects of TP on intestinal mucosa by regulating intestinal flora and the preventive and therapeutic effects on certain chronic diseases, which will help further explore measures to prevent related chronic diseases.

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Fu instant tea ameliorates fatty liver by improving microbiota dysbiosis and elevating short-chain fatty acids in the intestine of mice fed a high-fat diet

Cited by 16 publications

References 39 publications

Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond

Health Benefits and Side Effects of Short-Chain Fatty Acids

Tea Polyphenols: A Natural Antioxidant Regulates Gut Flora to Protect the Intestinal Mucosa and Prevent Chronic Diseases

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