FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome

Attaoua, Redha; Mkadem, Samira Ait El; Radian, Șerban; Fica, Simona; Hanzu, Felicia A.; Albu, Alice; Gheorghiu, Monica Livia; Coculescu, M; Grigorescu, Florin

doi:10.1016/j.bbrc.2008.06.039

Cited by 79 publications

(66 citation statements)

References 24 publications

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“…Tan et al (40) reported an increase in insulin resistance and hiperinsulinemia in obese patients with polycystic ovary syndrome with the A allele, without effect on glucose levels. In other study, FTO was associated with both metabolic syndrome and glucose without finding an association to insulin resistance (41). Our findings of insulin resistance and elevated triglyceride levels in patients with TT genotype were different than previous, without a clear explanation.…”

Section: Discussioncontrasting

confidence: 99%

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

et al. 2016

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Section: Discussioncontrasting

confidence: 99%

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

et al. 2016

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“…A PCOS-t az egyik leggyakrabban előforduló endokrin betegségnek tartják a reproduktív korú nők körében [1][2][3]. Pontos előfordulási gyakoriságát nem egyszerű meg-…”

Section: Prevalenciaunclassified

“…határozni, részben a diagnosztikus kritériumok nem pontos tisztázása, illetve változása miatt [2][3][4][5]. A PCOS prevalenciája a NIH-kritériumokat figyelembe véve kö-rülbelül 6-8% a kaukázusi populációban.…”

Section: öSszefoglaló Közleményunclassified

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Genetikai és epigenetikai faktorok polycystás ovarium szindróma esetén

et al. 2016

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A polycystás ovarium szindróma kialakulásának pontos mechanizmusa a mai napig nem tisztázott, de környezeti, illetve genetikai tényezők nagy valószínűséggel szerepet játszhatnak a kialakulásában. Ezt a megállapítást alátámasztja a gyakran előforduló családi halmozódás is. A praenatalis időszakban elszenvedett teratogén hatások a postnatalis időszakban kialakuló krónikus betegségek kifejlődéséhez vezethetnek. A szerzők polycystás ovarium szindrómában a genetikai és epigenetikai tényezők szerepével foglalkozó, 2016. január 1-jéig publikált szakirodalmi közlemények alapján szakirodalmi kutatást végeztek. Jelen összefoglaló közlemény célja e különleges betegségcsoportra való figyelemfelhívás, valamint e kórképek genetikai és epigenetikai hátterének ismertetése. Orv. Hetil., 2016, 157(32), 1275-1281. Kulcsszavak: polycystás ovarium szindróma, genetika, epigenetika Genetic and epigenetic factors of polycystic ovary syndromeThe development of polycystic ovary syndrome and its exact pathophysiological mechanism is still unclear, but environmental and genetic factors likely play a role. Exposition to teratogenic effects during the prenatal development can lead to chronic diseases in the postnatal period. This finding confirms the common familial aggregation as well. A literature search was conducted up to January 1, 2016 for articles dealing with the genetic or epigenetic factors of polycystic ovary syndrome. This review will discuss the current understanding of the genetic basis and clinical presentation of this disease. Keywords: polycystic ovary syndrome, genetics, epigeneticsHerczeg, Z., Vanya, M., Szili, K., Dézsi, Cs., Nagy, Zs., Szabó, J. [Genetic and epigenetic factors of polycystic ovary syndrome]. Orv. Hetil., 2016, 157(32), 1275-1281. Rövidítések ACTH = adrenokortikotrop hormon; AEPCOS = Androgen Excess and PCOS Society; AR = androgénreceptor; CAG repeat = citozin-adenin-guanin ismétlődés; FSH = folliculus stimulating hormone; FTO = alpha-ketoglutarate-dependent dioxygenase; GnRH = gonadotropin releasing hormone; GWAS = genome-wide association studies; INSR = inzulinreceptor-gén; LH = luteinizáló hormon; NIH = National Institutes of Health; PCOS = polycystás ovarium szindróma; SHBG = szexhormonkötő globulin; SNP = single nucleotide polymorphism; SRDA = szteroid-5-α-reduktáz A polycystás ovárium szindróma (PCOS) definíciója a szindróma 1935-ös, Stein és Leventhal általi leírása óta a gyarapodó ismeretanyag ellenére a mai napig sem tisztá-zott. PrevalenciaA PCOS-t az egyik leggyakrabban előforduló endokrin betegségnek tartják a reproduktív korú nők körében [1][2][3]. Pontos előfordulási gyakoriságát nem egyszerű meg-

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“…[11][12][13] PCOS and T2D are obesity-related conditions that share epidemiological and pathophysiological factors. [14][15][16] A large number of women with PCOS are considered to be overweight or obese, implicating BMI (body mass index) as an important determinant in the manifestation of the syndrome. [17][18][19] In recent, researchers identified heterogeneous associations between T2D susceptibility genes and risk of PCOS in multiple ethnic populations [20][21][22][23] but also demonstrated that its effect was likely through BMI.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition

Hwang

Lee

et al. 2012

J Hum Genet

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To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n ¼ 1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n ¼ 482) and in a gestational diabetes study (n ¼ 1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation.

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FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome

Cited by 79 publications

References 24 publications

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

Genetikai és epigenetikai faktorok polycystás ovarium szindróma esetén

Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition

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