FTIR and GCMS Analysis of Bioactive Phytocompounds in Methonalic Leaf Extract of Cassia Alata

Kavipriya, K.; Chandran, M.

doi:10.13005/bpj/1355

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…Igwe and Onwu (2015) [21] work also afforded n-Hexadecanoic and hexadecanoic acid methyl ester in the plant. According to Kavipriya and Chandran (2018) [23] , GC-MS Chemical analysis of Cassia alata showed 13 compounds that possess various pharmacological properties. The revelations on the plant constituents are in agreement with the work done.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition by gas chromatography and mass spectrometry and antioxidant activity of Cassia alata plant leaf

Igara¹,

Ndukwe²,

Ahuchaogu³

et al. 2023

J. Med. Plants Stud.

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Nature has provided humans with a diversity of medicinal plants employed in curing and taking care of many ailments. These medicinal plants contain many phytochemicals and bioactive compounds, which have been reported to possess some pharmacological properties. The study investigates the phytoconstituents and antioxidant activity shown by the Cassia alata plant leaf-a known medicinal plant. Gas chromatography-mass spectrometry (GC-MS) technique was applied in evaluating the chemical composition while Ferric reducing activity power (FRAP) and 2, 2-Dipheny l-1-picryl hydrazyl radical activity inhibition techniques were utilized to evaluate the antioxidant activity of methanol extract of the plant leaf. Ascorbic acid served as the standard. For different amounts of 50, 100, 200, and 400 µg/ml, the result of inhibitions of DPPH were revealed to be 4.14±0.00%, 12.99±0.55%, 19.55±0.06% and 25.73±0.17% respectively while that of the standard ranged from 18.41±0.17% -88.39±0.09%. Also, the FRAP results at different amounts of 50, 100, 200 and 400 µg/ml are detected to be 0.00±0.00% , 2.72±0.02%, 5.66±0.06% and 11.5±0.34% while the standard ranged from 5.09±0.16% -52.99±0.21%.The GC-MS chemical assay of C. alata extracts afforded ten compounds which include 1-Butanol-3-methyl acetate, Pentadecane, 2, 6, 10, 14-tetramethyl., β-D-Glucopyranose-4-o-βgalactopyranosyl, Hexadecanoicacid-methyl ester, n-Hexadecanoic acid, 9, 12, 15-Octadecatrienoic acid methyl ester [ZZZ], Phytol, 9, 12, 15-Octadecatrienoic -2, 3-dihydroxyl propyl ester, Ethyl -isoallocholate and Vitamin E. Hexadecanoic acid-methyl ester was found to the highest 77.1% in composition while 9, 12, 15-Octadecatrienoic -2-3-dihydroxyl propyl ester 8.6% was detected to be the least. Some of these bioactive compounds have been observed to have pharmacological and biological activities which are desirable in pharmaceutical formulations.

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Section: Resultsmentioning

confidence: 99%

Chemical composition by gas chromatography and mass spectrometry and antioxidant activity of Cassia alata plant leaf

Igara¹,

Ndukwe²,

Ahuchaogu³

et al. 2023

J. Med. Plants Stud.

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“…The GC–MS analysis of the sample was done using adapted methods described in the literature 19 , 20 , 31 – 35 . Five milligrams (5 mg) of each herbal extract were added into a Thermo Scientific Reacti-Vial containing a Reacti-Vial magnetic stirrer.…”

Section: Methodsmentioning

confidence: 99%

“…This study investigated the chemical composition and therapeutic potential of M. crassa . The gas chromatography-mass spectrometry (GC-MS) 18 , 19 and fourier transform infrared (FT-IR) spectrometry 20 were used to identify compounds and functional groups in the extracts of this plant species. Molecular docking was used to evaluate the therapeutic potential of the identified compounds by testing their binding affinities on druggable receptor proteins in dental pain and inflammation pathways that involve activation of classical cyclooxygenases, interleukin-1 beta receptors 21 , odontoblast cold sensor proteins 22 , and the purinergic receptor P2X3 23 – 30 .…”

Section: Introductionmentioning

confidence: 99%

GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry

Chikowe,

Bwaila,

Ugbaja

et al. 2024

Sci Rep

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Plant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluated Multidentia crassa (Hiern) Bridson & Verdc, one of the oral health-used plants in Malawi. Gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FT-IR) identified the extracts’ compounds. The pharmacokinetics of the identified compounds were studied using pkCSM and SwissADME, and molecular docking studies were used to identify potential drug candidates for oral health by predicting the binding affinity of the compounds to cyclooxygenases, interleukin-1 beta receptors, odontoblast cold sensor proteins, and purinergic receptor P2X3. FT-IR analysis showed characteristic peaks of phenols, carboxylic acids, alkenes, alkyl halides, amines, esters, ethers, aromatics, and lipids. GC–MS results showed the presence of 58 bioactive phytocompounds, some of which have various pharmacological activities relevant to oral health. Molecular docking further validated stigmastan-3,5-diene’s potency for analgesic and anti-inflammatory purposes. Based on a literature review, this is the first report on the bioactive compounds of M. crassa extracts showing analgesic and anti-inflammatory effects. This study's results can lead to new herbal and conventional medicines. Therefore, we recommend in vivo and in vitro studies to elucidate the pharmacological effects of the plant extracts.

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“…As regards 1,6-anhydroβ-D-glucopyranose (levoglucosan), it is an anhydrohexose found in Lotus creticus L., Lotus filicaulis Durieu, Equisetum arvense L. [32], and Sambucus nigra L. [33]. It is employed for making biochemically significant substances like (+)-biotin, indanomycin, macrolide antibiotics, quinone, rifamycin S, tetrodotoxin, and thromboxane B2 [34]. Catechol is a benzenediol whose chemical structure is close to that of 4-ethenyl-1,3-benzenediol.…”

Section: On the Phytochemical Profilementioning

confidence: 99%

Helichrysum stoechas (L.) Moench Inflorescence Extract for Tomato Disease Management

et al. 2023

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Helichrysum stoechas is a singular halophyte that has been shown to have anti-inflammatory, antioxidant, and allelopathic properties. In the work presented herein, we have characterized its inflorescences hydromethanolic extract and assessed its antifungal activity for the pre- and postharvest management of tomato crop diseases. Gas chromatography–mass spectrometry characterization of the extract showed that 4-ethenyl-1,3-benzenediol, 2,3-dihydro-benzofuran, quinic acid, 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-1-benzopyran-4-one, 1,6-anhydro-β-D-glucopyranose, catechol, scopoletin, and maltol were the main constituents. The co-occurrence of pyranones, benzenediols, and quinic acids as phytoconstituents of H. stoechas extract resulted in promising in vitro minimum inhibitory concentrations of 500, 375, 500, 187.5, 187.5, and 375 μg·mL−1 against mycelia of Alternaria alternata, Colletotrichum coccodes, Fusarium oxysporum f. sp. lycopersici, Rhizoctonia solani, Sclerotinia sclerotiorum, and Verticillium dahliae, respectively. Further, to assess the potential of H. stoechas inflorescence extract for postharvest tomato crop protection, ex situ tests were conducted against C. coccodes, obtaining high protection at a dose of 750 μg·mL−1. Taking into consideration that the demonstrated activity is among the highest reported to date for plant extracts and comparable to that of the synthetic fungicides tested as positive controls, H. stoechas inflorescence extract may be put forward as a promising biorational and may deserve further testing in field-scale studies.

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FTIR and GCMS Analysis of Bioactive Phytocompounds in Methonalic Leaf Extract of Cassia Alata

Cited by 10 publications

References 7 publications

Chemical composition by gas chromatography and mass spectrometry and antioxidant activity of Cassia alata plant leaf

Chemical composition by gas chromatography and mass spectrometry and antioxidant activity of Cassia alata plant leaf

GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry

Helichrysum stoechas (L.) Moench Inflorescence Extract for Tomato Disease Management

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