Fruit Bromelain-Derived Peptide Potentially Restrains the Attachment of SARS-CoV-2 Variants to hACE2: A Pharmacoinformatics Approach

Tallei, Trina Ekawati; Fatimawali, Fatimawali; Adam, Ahmad Akroman; Elseehy, Mona M.; El-Shehawi, Ahmed M.; Mahmoud, Eman A.; Tania, Adinda Dwi; Niode, Nurdjannah J.; Kusumawaty, Diah; Rahimah, Souvia; Effendi, Yunus; Idroes, Rinaldi; Çeli̇k, İsmail; Hossain, Md. Jamal; Emran, Talha Bin

doi:10.3390/molecules27010260

Cited by 22 publications

(19 citation statements)

References 85 publications

(107 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Viruses with mutations in their genomes will dominate the population, regardless of their impact on viral fitness [ 7 ]. According to the Centers for Disease Control and Prevention (CDC), SARS-CoV-2 variants are classified into four classes, namely: “variants being monitored (VBM)”, “variants of interest (VOI)”, “variants of concern (VOC)”, and “variants of high consequence (VOHC)” ( ; accessed on 31 January 2022) [ 15 , 16 , 17 ]. VBM are variants that have been linked to more severe illness or increased transmission, but are no longer detectable or are circulating at extremely low levels.…”

Section: Sars-cov-2 Mutation Results In the Emergence Of Various Vari...mentioning

confidence: 99%

Can the SARS-CoV-2 Omicron Variant Confer Natural Immunity against COVID-19?

et al. 2022

Self Cite

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, with no signs of abatement in sight. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of this pandemic and has claimed over 5 million lives, is still mutating, resulting in numerous variants. One of the newest variants is Omicron, which shows an increase in its transmissibility, but also reportedly reduces hospitalization rates and shows milder symptoms, such as in those who have been vaccinated. As a result, many believe that Omicron provides a natural vaccination, which is the first step toward ending the COVID-19 pandemic. Based on published research and scientific evidence, we review and discuss how the end of this pandemic is predicted to occur as a result of Omicron variants being surpassed in the community. In light of the findings of our research, we believe that it is most likely true that the Omicron variant is a natural way of vaccinating the masses and slowing the spread of this deadly pandemic. While the mutation that causes the Omicron variant is encouraging, subsequent mutations do not guarantee that the disease it causes will be less severe. As the virus continues to evolve, humans must constantly adapt by increasing their immunity through vaccination.

show abstract

Section: Sars-cov-2 Mutation Results In the Emergence Of Various Vari...mentioning

confidence: 99%

Can the SARS-CoV-2 Omicron Variant Confer Natural Immunity against COVID-19?

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Tallei et al used the HawkDock server to evaluate the BFE to understand the attachment of a fruit-derived small peptide. It has been noted that the small peptide can restrain the attachment of variants of SARS-CoV-2 RBD to hACE2 ( Tallei et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India

Chakraborty

Sharma

Bhattacharya

et al. 2022

Infection, Genetics and Evolution

View full text Add to dashboard Cite

“…Tallei et al [53] revealed that a fruit bromelain-derived peptide DYGAVNEVK interacts with several critical SARS-CoV-2 spike glycoprotein receptor-binding domain binding residues responsible for the adhesion of the receptor-binding domain to human angiotensin-converting enzyme 2 receptors and restrains its attachment. Akhter et al [54] revealed that bromelain and acetylcysteine (BromAc) have synergistic action against glycoproteins of SARS-CoV-2 by breakage of its glycosidic linkages and disulfide bonds.…”

Section: Bromelain and Covid-19mentioning

confidence: 99%

Bromelain: A Potent Phytomedicine

Agrawal¹,

Nikhade²,

Patel³

et al. 2022

Cureus

View full text Add to dashboard Cite

The commercially available protein-digesting enzyme bromelain is derived from the pineapple fruit or stem. Bromelain from fruit and stems are produced in different ways and has varied enzyme compositions. "Bromelain" often refers to the "stem bromelain". Bromelain is a combination of several thiol endopeptidases and others including various protease inhibitors, glucosidase, cellulase, phosphatase, peroxidase, and escharase. Studies conducted in both the lab and on animals show that bromelain has a variety of fibrinolytic, anti-edematous, antithrombotic, and anti-inflammatory effects. The body can absorb bromelain to a significant extent without it ceasing its proteolytic activity or having any negative side effects. Numerous therapeutic advantages of bromelain include wound debridement, improved drug absorption, and the management of sinusitis, bronchitis, angina pectoris, surgical trauma, and thrombophlebitis. Additionally, it treats numerous cardiovascular conditions, diarrhoea, and osteoarthritis. Bromelain also encourages apoptotic cell death and exhibits some anti-cancerous properties. This review compiles the crucial traits, medical and dental uses of bromelain as well as its potential mechanism of action.

show abstract

Fruit Bromelain-Derived Peptide Potentially Restrains the Attachment of SARS-CoV-2 Variants to hACE2: A Pharmacoinformatics Approach

Cited by 22 publications

References 85 publications

Can the SARS-CoV-2 Omicron Variant Confer Natural Immunity against COVID-19?

Can the SARS-CoV-2 Omicron Variant Confer Natural Immunity against COVID-19?

Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India

Bromelain: A Potent Phytomedicine

Contact Info

Product

Resources

About