Background: Pulmonary physiotherapy (PPT) is an important therapeutic tool in the management of patients with different types of pulmonary disorders. We aimed to evaluate safety and efficacy of PPT in hospitalized patients with severe COVID-19 pneumonia.
Methods: In this randomised, single-blind, controlled trial, we enrolled hospitalized, non-intubated patients (18 to 75 years with oxygen saturation(Spo2) in free-air breathing ≤90%) with COVID-19 pneumonia at a referral hospital. Participants were randomly assigned(1:1) to receive PPT (six sessions PPT with breathing exercises and airway clearance techniques) or basic care. The primary outcomes were venous blood O2(pO2) and CO2(pCO2) pressures, Spo2, and three-minute walking test(3MWT) that were assessed before and end of sixth session. Secondary outcomes included level of dyspnea, venous blood PH, one-month mortality, three-month mortality and short form-36 (SF-36) after one and three months. The assessor was blinded to the assignment. This trial is registered with ClinicalTrials.gov(NCT04357340).
Findings: In April and May 2020, 40 participants were randomly assigned to PPT or basic care groups. At the end of intervention, pO2(adjusted mean difference to baseline measure (AMD) 6⸱43 mmHg [95%CI 2⸱8, 10⸱07], P<0.0001), pCO2(AMD -2⸱1 mmHg [95%CI-6⸱36, 2⸱21], P=0.0011), Spo2(AMD 4⸱43% [95%CI 2⸱04, 6⸱83], P=0.0011), and 3MTW (AMD 91⸱44 m [95%CI 68⸱88, 113⸱99], P<0.0001) were improved higher in PPT group and basic care group. While the mortality rate was not different at one month, at three months it was 25% lower in the PPT group (P=.05). There were no significant differences in most SF-36 domains scores between groups after one and three months. No serious adverse event was observed during PPT sessions.
Conclusion: Early PPT can be considered as a safe and effective therapeutic choice for patients with severe COVID-19.