Fructus aurantii reduced portal pressure in portal hypertensive rats

Huang, Yo-Ping; Wang, Gueih-Fen; Chen, Chieh-Fu; Chen, Chien-Chih; Hong, Chuang‐Ye; Yang, Meng

doi:10.1016/0024-3205(95)02195-o

Cited by 53 publications

(38 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A hesperidina é o principal glicosídio encontrado nas laranjas doces e a neoesperidina, nas laranjas amargas (Arriaga; Rumbero, 1990). O fruto imaturo contém sinefrina e n-metiltiramina (Huang et al, 1995). Dados farmacológicos: O óleo volátil da casca do fruto apresentou atividade sedativa/hipnótica, contrastando com o extrato etanólico das folhas, que não apresentou esta atividade (Carvalho-Freitas; Costa, 2002).…”

Section: Citrus X Aurantium L (Rutaceae) -unclassified

“…Este efeito foi atribuído à atividade β-adrenérgica da sinefrina (Calapai et al, 1999). Esta substância também está correlacionada com uma ação redutora da pressão portal, possivelmente através de uma vasoconstrição arterial, detectada na infusão da casca do fruto (Huang et al, 1995 (Desmarchelier et al, 1998;Simões, 1984;Ferraro et al, 1981), ácido clorogênico e isoclorogênico (Desmarchelier et al, 1998), derivados da fenilpirona e cavapirona (Kaloga et al, 1983), fl avonóides (Desmarchelier et al, 1998;Mesquita et al, 1986;Simões, 1984), minerais (Puhlmann et al, 1992;Bassani, 1990), óleos voláteis (Lorenzo et al, 2000) e polissacarídeos (Puhlmann et al, 1992;Wagner et al, 1985). Para revisão, ver Petrovick et al (1997).…”

Section: Citrus X Aurantium L (Rutaceae) -unclassified

unclassified

See 2 more Smart Citations

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Vendruscolo¹,

Rates²,

Mentz³

2005

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Para estas espécies foi realizada uma revisão bibliográfi ca, buscando estudos sobre sua constituição química e atividade farmacológica. Para todas as espécies foram encontrados dados químicos e para nove delas dados de atividade farmacológica. Foram encontrados estudos clínicos para quatro espécies e usos terapêuticos aprovados por organismos internacionais para três espécies. Efeitos adversos foram encontrados, na literatura, para cinco das dez espécies pesquisadas e para seis destas, o uso durante a gestação é desaconselhado.Unitermos: Etnobotânica, plantas medicinais, farmacologia.ABSTRACT: "Chemical and pharmacologic data on medicinal plants used by the community of the Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil". The ten most important species among all plants used as medicinal by the residents and Communitary Agents of Health from the Family Health Offi ce of Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil were selected. A bibliographical review for these species was accomplished, fi nding studies about the chemical constitution for all species and some pharmacologic activity for nine of them. Clinical studies for four species and therapeutic uses approved by international organisms for three species were found. It was verifi ed that according to the literature, adverse effects for fi ve of the ten researched species and for six of these the use is dissuaded during the gestation.Keywords: Ethnobotany, medicinal plants, pharmacology. INTRODUÇÃONo Brasil, a possibilidade de implementação da fi toterapia no sistema público de saúde vem sendo considerada desde 1988 (CIPLAN) e faz parte das diretrizes da I Conferência Nacional de Assistência Farmacêutica (CNMAF, 2003). A partir de então, várias inicativas pontuais para estabelecer a fi toterapia na rede pública de sáude vêm ocorrendo, com destaque para o Programa de Fitoterapia do Ceará, alicerçado no Projeto Farmácias Vivas, idealizado pelo Prof. Francisco José de Abreu Matos (Matos et al., 2001). No entanto, para a maioria das plantas nativas não existem estudos científi cos e o uso no Brasil é baseado principalmente na tradicionalidade. A OMS reconhece a importância do uso tradicional, mas para a utilização de uma planta com fi nalidade terapêutica, em nível de saúde pública, é fundamental o estabelecimento de sua segurança, efi cácia e garantia de qualidade das preparações (Lapa et al., 2003; WHO, 2002;Rates, 2001). O uso inadequado destes recursos terapêuticos pode originar efeitos adversos retardados e/ou assintomáticos, interações medicamentosas ainda não estudadas e difi cilmente reconhecidas, além de retardar o diagnóstico e tratamento apropriado (Cañigueral; Vila, 2003;Rates, 2001). Nestes termos, o emprego no atendimento primário à saúde pode gerar um impacto social (Lapa et al., 2003), com aumento de gastos nos serviços públicos de saúde, visto que as plantas com maior volume de estudos científi cos que garantam efi cácia e segurança constituem matéria-prima importada, o que torna urgente a busca de inform...

show abstract

Section: Citrus X Aurantium L (Rutaceae) -unclassified

See 1 more Smart Citation

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Vendruscolo¹,

Rates²,

Mentz³

2005

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Chemical compounds found in the plant are hydrocarbons, alcohols, some form of acetate, acids and phenols. Flavonoids are a class of polyphenols that are present in extracts of citrus aurantium flowers [9]. Citrus fruits are a common food source because of their nutrient, flavor, and intrinsic characteristics.…”

Section: Introductionmentioning

confidence: 99%

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

2017

JCCR

View full text Add to dashboard Cite

The citrus aurantium has traditionally been used by the people of Iran. The aim of this study was to evaluate the protective effects of hydroalcholic citrus aurantium extract on electrocardiographic, biochemical and pathological changes after myocardial infarction induced by isoproterenol in rats. 24 male Wistar rats were divided randomly into 4 groups: Control, extract, isoproterenol, and isoproterenol + pre-treatment with extract for two weeks. At the end of the experiment, ECG was recorded in lead II. Finally, blood samples were taken and cardiac marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, along with oxidative stress markers such as malondialdehyde, superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and lipid profile were determined.Myocardial infarction induced by isoproterenol produced a significant increase in the heart rate, ST-segment elevation, decrease in R amplitude, and a significant increase in the level of cardiac marker enzymes: LDH, CK-MB, AST, ALT and ALP in serum. Also, isoproterenol significantly reduced SOD, CAT, GSH, GP X and increased MDA activity, disturbance in lipid profile, and inflammatory process in cardiac myocytes. Pretreatment with citrus aurantium extract for two weeks significantly reduced the effect of isoproterenol on electrocardiographic parameters, cardiac biomarkers, oxidative stress indices, lipid profile and cardiac myocytes injuries.Results indicated that citrus aurantium extract ameliorates the cardio-toxic effects of isoproterenol through reinforcement of antioxidant defense system and may be of value in treatment of myocardial infarction. Further studies are required to determine the precise mechanism of the therapeutic effect of the extract.

show abstract

“…A recent clinical study also indicated that propranolol could not prevent the development of large esophageal varices in cirrhotic patients after 2-year treatment (5). In the context of making efforts to find some potential alternatives from the Chinese materia medica, we have reported previously that acute intravenous administration of the aqueous extract of Citrus aurantium L or its active principle synephrine dose dependently reduced portal pressure and increased arterial pressure in portal vein stenosed rats, suggesting similar mechanisms of action to those induced by such vasoconstrictors as vasopressin (6). Synephrine (1-[4-hy-droxyphenyl]-2-methyl-aminoethanol, C9H13NO2, molecular weight, 167.2), a sympathomimetic compound with aadrenoceptor-mediated vasoconstrictive activity (6), is one of the active principles in Citrus aurantium, and it has been shown to increase systemic arterial pressure after intravenous infusion into humans as well as animals (7 -9).…”

mentioning

confidence: 99%

Hemodynamic Effects of Synephrine Treatment in Portal Hypertensive Rats

Huang¹,

Chang³

et al. 2001

Japanese Journal of Pharmacology

Self Cite

View full text Add to dashboard Cite

ABSTRACT-Synephrine, a sympathomimetic a1-adrenoceptor agonist, has been shown to induce dosedependent portal hypotensive effects after acute intravenous infusion. The present study was undertaken to investigate the hemodynamic effects of 8-day administration of synephrine in portal hypertensive rats. Portal hypertension was induced by either partial portal vein ligation (PVL) or bile duct ligation (BDL). Portal hypertensive rats were allocated into one of two groups: vehicle group (0.1 N HCl, 0.5 ml/ 12 h) or synephrine group (1 mg/kg per 12 h), with 7 rats in each group. Synephrine or vehicle was administered by gavage into PVL and BDL rats for 8 consecutive days. Systemic as well as splanchnic hemodynamic parameters were measured thereafter. Synephrine significantly ameliorated the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats (-13.5% and -10.1%, respectively), portal tributary blood flow (-19.5% and -20.4%) and cardiac index (-12.1% and -18.8%) were significantly reduced, while mean arterial pressure (10.4% and 23.4%) and systemic (26.3% and 51.0%) as well as portal territory (47.1% and 67.7%) vascular resistance were enhanced by treatment of synephrine as compared with vehicle treatment. Our results showed that eight-day administration of synephrine exerted beneficial hemodynamic effects in two models of portal hypertensive rats.

show abstract

Fructus aurantii reduced portal pressure in portal hypertensive rats

Cited by 53 publications

References 14 publications

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

Hemodynamic Effects of Synephrine Treatment in Portal Hypertensive Rats

Contact Info

Product

Resources

About