Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Azevedo, Vittoria Zambon; Dall’Alba, Valesca

doi:10.1016/j.clnu.2021.01.022

Cited by 5 publications

(8 citation statements)

References 42 publications

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“…Total cholesterol intake did not differ between NAFLD and healthy controls, either (Suppl. Figure 3) Total fat intake did not differ between patients with NASH and NAFLD (MD=0.57; 95%CI: -2.50, 3.64, p=0.72; I 2 =75%, p<0.001) (5 studies, 148 NASH patients vs. 169 patients with NAFLD, Figure 3E) 42,[44][45][46]55 .…”

Section: Fatmentioning

confidence: 94%

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Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease

Tsompanaki

Thanapirom

Papatheodoridi

et al. 2023

Clinical Gastroenterology and Hepatology

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Section: Fatmentioning

confidence: 94%

“…-366.44, 8.85, p=0.06; I 2 =81%, p<0.001), although available data were limited in 4 studies 22,42,[44][45][46] (622 NASH and 614 NAFLD patients) (Figure 1B).…”

Section: Total Caloric Intakementioning

confidence: 99%

Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease

Tsompanaki

Thanapirom

Papatheodoridi

et al. 2023

Clinical Gastroenterology and Hepatology

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“…However, in the current study, we detected no statistically significant link between the “High-Sugar” pattern consumption and MRI parameters. Interestingly, another research group found no association between fructose intake and NAFLD or risk of hepatic fibrosis; however, in this study, underreporting of sugar intake due to overweight/obesity and diabetes might be the reason for the lack of association [ 26 ].…”

Section: Discussionmentioning

confidence: 72%

“…Numerous studies have described the link between foods and nutrients and the risk of NAFLD [ 24 , 25 , 26 , 27 , 28 ]. In addition, several studies have explored the association of dietary patterns and NAFLD risk.…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study

Amanatidou

Kaliora

Amerikanou

et al. 2022

IJERPH

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Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron-corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet and food combinations. Other variables investigated include anthropometric measurements, total type 2 diabetes risk, physical activity level (PAL), and smoking status. Principal component analysis (PCA) was performed to identify dietary patterns. Six dietary patterns were identified, namely “High-Sugar”, “Prudent”, “Western”, “High-Fat and Salt”, “Plant-Based”, and “Low-Fat Dairy and Poultry”. The “Western” pattern was positively associated with cT1 in the unadjusted model (beta: 0.020, p-value: 0.025) and even after adjusting for age, sex, body mass index (BMI), PAL, smoking, the center of the study, and the other five dietary patterns (beta: 0.024, p-value: 0.020). On the contrary, compared with low-intake patients, those with medium intake of the “Low-Fat Dairy and Poultry” pattern were associated with lower values of cT1, PDFF, and LIF. However, patients with a “Low-Fat Dairy and Poultry” dietary pattern were negatively associated with MRI parameters (cT1: beta: −0.052, p-value: 0.046, PDFF: beta: −0.448, p-value: 0.030, LIF: beta: −0.408, p-value: 0.025). Our findings indicate several associations between MRI parameters and dietary patterns in NAFLD patients, highlighting the importance of diet in NAFLD.

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“…Существующие вопросы в отношении роли фруктозы при НАЖБП. Хотя с позиции полученных доказательств роль фруктозы в качестве фактора риска НАЖБП представляется весьма вероятной, особенно в высококалорийных рационах, существуют не подтверждающие и противоположные данные [16,39,41,42]. Высокое потребление фруктозы, которое сопровождается избыточным потреблением энергии, а не фруктоза как таковая, связано с повышением уровня глюкозы и ТГ в крови и значительно способствует печёночному стеатозу.…”

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Non-Alcoholic Fatty Liver Disease: With a Focus on Fructose

Silivontchik¹,

Штонда²

2021

Hepatol and Gastroenterol

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Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in the liver in the absence of secondary causes. The review presents data on the role of fructose in the accumulation of fat in the liver and the mechanisms of NAFLD development. A number of data have been obtained on the effects of fructose, in the form of sugar-containing and fructose-containing drinks, related to NAFLD development.

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Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)

Cited by 5 publications

References 42 publications

Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease

Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease

Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study

Non-Alcoholic Fatty Liver Disease: With a Focus on Fructose

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