Frozen section evaluation of lymph nodes in Oral squamous cell carcinoma - A retrospective study

Desai, Dinkar; Kumar, G. Santhosh

doi:10.4317/jced.2.e67

Cited by 4 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adipose tissue should therefore be removed as far as possible and several sections should be prepared to allow accurate observation of all sections of the lymph nodes. 9 In this study the sensitivity of frozen section is around 32.5% with a specificity of 97.1%. This is in accordance with the study by Rassekh CH et al on cervical lymph nodes for metastasis from aero digestive tract neoplasm and in which accuracy of 92.3% was determined.…”

Section: Roc Curvementioning

confidence: 52%

“…10 Wada et al &Kurosumi et al who have reported intraoperative sensitivity for lymph nodes in breast cancer in the range of 47% to 74% whereas in melanoma the sensitivity ranges from 38% to 47% [Ferris]. 9,4 Many patients have to undergo second surgeries to complete lymph node dissection in cases in which definitive pathologic assessment identifies metastasis that were missed on the frozen section examination. The limitation of frozen section is that it is most accurate at detecting the foci of nodal metastasis that are > 2mm in size, therefore deposits less than 2mm are missed.…”

Section: Roc Curvementioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Accuracy of Various Methods to Detect Lymph Node Metastases in Oral Squamous Cell Carcinoma

Agarwal¹,

Chaudhary²,

Patil³

et al. 2014

jemds

View full text Add to dashboard Cite

The present study was undertaken with the purpose to compare the sensitivity of various methods for detection of lymph node metastases:Intra-operative frozen sections H & E staining, Conventional H & E staining on formalin fixed tissue, Serial -step sectioning by conventional H&E staining & Immunohistochemical staining by Pancytokeratin antibody. METHOD: The study included 80 consecutive cases of oral squamous cell carcinoma, who underwent radical neck dissection. The various level of lymph nodes in these cases were checked for metastases by 4 techniques i.e. intra-operative frozen sections H&E staining, conventional H&E staining on formalin fixed tissue, serial -step sectioning by conventional H & E staining &immunohistochemical staining by Pancytokeratin antibody. RESULTS: Considering IHC as a gold standard, we observed highest sensitivity & specificity for serial sectioning at 53.7%, & 98.9% when compared to intraoperative frozen section and conventional H&E which were 32.5%, 97.1% & 44.7%, 98.2% respectively. CONCLUSION: Thus we conclude that the most sensitive method to detect lymph node metastasis in case of Oral Squamous cell carcinoma is step serial section when considering IHC as a gold standard.

show abstract

Section: Roc Curvementioning

confidence: 52%

Section: Roc Curvementioning

confidence: 99%

Diagnostic Accuracy of Various Methods to Detect Lymph Node Metastases in Oral Squamous Cell Carcinoma

Agarwal¹,

Chaudhary²,

Patil³

et al. 2014

jemds

View full text Add to dashboard Cite

show abstract

“…A definite immediate diagnosis is said to be dependent on the reliability of frozen sections. 15 Many authors have carried out frozen section study on soft tissue tumors and margins evaluation in the different parts of body, with varying percentages of reliability. 12,16 Frozen sections have been used both in the diagnosis and to evaluate margins.…”

Section: Discussionmentioning

confidence: 99%

“…In most publications, accuracy for such diagnosis is 96.8% to 98%. 7,13,15,17 The diagnosis on lesions in different regions of the body were varied in their accuracy form 91.5% to 98%, 10 and in head and neck neoplasm 96% to 99%. 3,7,17 There are essentially two main sources of frozen section errors.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of intraoperative frozen section in assessing margins in oral cancers: A tertiary care hospital based study

Pandey¹,

Bhamra²,

Singh³

2020

IJPO

View full text Add to dashboard Cite

To study the accuracy of intraoperative frozen section diagnosis in assessing margins in oral cancer resection. But reliability of frozen sections in predicting the ultimate final margin status is unknown. We compared frozen and permanent reads to identify risk factors for overall discrepancies between intraoperative and final margin status. To evaluate the role of frozen section diagnosis as a guide in resection of oral cancer lesions. Pathology reports of 284 surgical resections specimens between 2018 and 2020 were retrospectively reviewed. A total of 104 cases (470) margins) met inclusion criteria. The reports of frozen sections are compared with the results of histologic findings obtained by routine paraffin embedded Haematoxylin and Eosin method. The comparison of the section from margins i.e. anterior, posterior, medial, lateral and deep, altogether 470 margins from 104 patients showed concordance in 437 margins, i.e. 446 margins were negative in both frozen section and Paraffin method and 16 margins were positive in both frozen section and Paraffin method. 22 margins were positive in paraffin method. 18 margins were positive in frozen section. The eight margins showed disagreement in frozen section and paraffin embedded Haematoxylin and Eosin method. Individual frozen section reads are highly accurate. However, negative intraoperative margins do not guarantee margin-negative resections. The process of selecting representative margins for intraoperative analysis should be refined. The surgeon and the pathologist must understand the limitations of frozen sections.

show abstract

“…Intraoperative evaluation of lymph nodal metastasis in head and neck carcinoma assumes importance in deciding the extent of lymph node dissection. Accuracy of the FZ has been studied extensively in the evaluation of margin status in head and neck cancer, whereas studies analyzing the use of FZ in the evaluation of neck nodes in head and neck cancer are limited 5,7‐15 . In most of these studies, the specificity of the FZ in the evaluation of neck nodes in head and neck cancer is close to 100% whereas sensitivity varies from 43% to 93%.…”

Section: Discussionmentioning

confidence: 99%

Comparison of intraoperative imprints cytology with frozen section for lymph node metastasis in patients with head and neck squamous cell carcinoma

Neduvanchery

Gochhait

Srinivas

et al. 2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

BackgroundIntraoperative evaluation of lymph nodal metastasis in head and neck squamous cell carcinoma (HNSCC) assumes importance and avoids over‐treatment in clinically node negative (N0) neck. Frozen section (FZ) is the commonly employed technique, but it requires significant investment in resources, time, and personnel. Intraoperative imprint cytology (IC) is a rapid, reliable, and inexpensive alternative. We conducted a prospective study to assess the diagnostic accuracy of intraoperative IC and FZ for lymph node metastasis in HNSCC.MethodsAll patients presenting with HNSCC with clinically N0 neck undergoing surgery were included in the study, and intraoperative assessment of clinically suspicious nodes was done using IC and FZ and was reviewed by two independent pathologists. The sensitivity, specificity, and accuracy of IC and FZ were calculated with reference to the final histopathology report. The time duration for reporting was calculated.ResultsThirty‐four patients with clinically N0 neck were included in the study, and 85 slides were examined. The sensitivity, specificity, and accuracy of FZ were 100%, 98.6%, and 98.9%, respectively, whereas for IC, it was 85.7%, 95.8%, and 94.1%, respectively. The mean time duration for reporting for FZ and IC was 41.18 ± 3.62 and 18.12 ± 2.01 minutes, respectively.ConclusionIC provides a cheaper, accurate, and rapid alternative for FZ for intraoperative assessment of neck nodes in HNSCC, and it assumes importance in resource‐driven countries like India.

show abstract

Frozen section evaluation of lymph nodes in Oral squamous cell carcinoma - A retrospective study

Cited by 4 publications

References 14 publications

Diagnostic Accuracy of Various Methods to Detect Lymph Node Metastases in Oral Squamous Cell Carcinoma

Diagnostic Accuracy of Various Methods to Detect Lymph Node Metastases in Oral Squamous Cell Carcinoma

Accuracy of intraoperative frozen section in assessing margins in oral cancers: A tertiary care hospital based study

Comparison of intraoperative imprints cytology with frozen section for lymph node metastasis in patients with head and neck squamous cell carcinoma

Contact Info

Product

Resources

About