Frontotemporal Dementia

Rosen, Howard J.; Lengenfelder, Jeannie; Miller, Bruce L.

doi:10.1016/s0733-8619(05)70235-8

Cited by 32 publications

(23 citation statements)

References 71 publications

(25 reference statements)

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“…Fifteen percent or more of FTD patients develop amyotrophic lateral sclerosis (ALS) and these patients typically die within 1.4 years from the time of diagnosis. [30][31][32][33] Corticobasal degeneration (CBD) is a clinically and pathologically heterogeneous atypical parkinsonian dementia often confused clinically with AD, PSP, or FTD. [34][35][36][37][38] Many features of CBD, including myoclonus, alien limb and visual, sensory and motor deficits overlap with features of CJD.…”

Section: Typically Chronic Degenerative Dementiasmentioning

confidence: 99%

Rapidly Progressive Dementia

2007

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Rapidly progressive dementias (RPDs) are neurological conditions that develop subacutely over weeks to months, or rarely acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD can be quickly fatal. It is critical to evaluate the RPD patient without delay, usually in a hospital setting, as they may have a treatable condition. In this review, we discuss a differential diagnostic approach to RPD, emphasizing neurodegenerative, toxic/metabolic, infectious, autoimmune, neoplastic, and other conditions to consider.

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Section: Typically Chronic Degenerative Dementiasmentioning

confidence: 99%

Rapidly Progressive Dementia

2007

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“…Patients may deny the existence of deficits and often show a lack of concern about their illness. 18 Increased submissiveness, a lack of empathy, self-centeredness, emotional coldness, and decreased concern about family and friends is also common. 19 Patients with evidence of right brain involvement on neuroimaging studies tend to have the most severe behavioral symptoms.…”

Section: Behavioral/dysexecutive Frontotemporal Dementia (Frontal Lobmentioning

confidence: 99%

“…Disinhibition or distractibility may manifest as restlessness, pressured speech, impulsivity, irritability, aggressiveness, violent outbursts, or excessive sentimentality. 18 Damage to orbitofrontal structures also leads to a decrease in patients' ''agreeableness,'' a construct that encompasses the traits of trust, straightforwardness, altruism, compliance, modesty, and tender-mindedness. 22 Verbally inappropriate sexual comments and gestures are common in FTD.…”

Section: Behavioral/dysexecutive Frontotemporal Dementia (Frontal Lobmentioning

confidence: 99%

Clinical Features of Frontotemporal Dementia

Boxer

Miller

2005

Alzheimer Disease &Amp; Associated Disorders

106

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What was once called Pick's disease has three major anatomic variants. With all three, frontotemporal brain is selectively injured whereas posterior cortical regions are spared. These three clinical patterns include a bifrontal, slightly asymmetric subtype with more involvement of the right frontotemporal region called frontotemporal dementia or the frontal variant of FTD (fvFTD), a temporal-predominant subtype called the temporal variant of FTD or semantic dementia (SD), and a left frontal-predominant subtype called progressive nonfluent aphasia (PNFA). The three anatomic groups help to classify distinctive clinical syndromes with unique features. Careful study of these subtypes of frontotemporal dementia, using combinations of new quantitative neuroimaging, behavioral and physiological measures are yielding important information about the functioning of the brain's frontal and temporal regions. As we come to better understand the biologic basis for the three FTD clinical syndromes, new classification schemas may emerge, but our current clinical criteria serve as a strong guide to the diagnosis and separation of FTD from Alzheimer disease and other dementias.

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“…Furthermore, individuals may sometimes progress to other forms of dementia, such as vascular dementia in the case of multiple-domain and single non-memory-domain MCI, and primary progressive aphasia (Mesulam, 2001), frontotemporal dementia (Rosen, Lengenfelder, & Miller, 2000) or Lewy body dementia (Ferman, Boeve, Smith, Silber, et al, 1999) in the case of single non-memory-domain MCI. Thus, MCI is best viewed as a 'prodromal, at-risk condition for AD ' (Peterson, 2003).…”

Section: Introductionmentioning

confidence: 99%