Frontoparietal function in young people with dysthymic disorder (DSM-5: Persistent depressive disorder) during spatial working memory

Vilgis, Veronika; Chen, Jian; Silk, Tim; Cunnington, Ross; Vance, Alasdair

doi:10.1016/j.jad.2014.01.024

Cited by 24 publications

(13 citation statements)

References 79 publications

(97 reference statements)

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“…The exception here is the SN, for which the classifier performed better in the PDD group compared to the other two groups, and this increased AUC measure appears to be driven by both higher specificity and sensitivity. Overall, our results confirm our hypotheses and are consistent with the large body of research that has shown differences in the neural underpinnings between patient groups diagnosed with ADHD or clinical depression and non-clinical groups during working memory tasks (e.g., Burgess et al, 2010;Matsuo et al, 2007;Mills et al, 2012;Vance et al, 2007;Vilgis et al, 2014;Walter et al, 2007;Wolf et al, 2009). Group differences in classifier performance during the control condition most notable in the DMN and SN are particularly intriguing, as resting-state investigations have previously shown atypical functional connectivity of these networks at rest in patients with ADHD and patients with clinical depression (e.g., Cortese et al, 2021;Mulders et al, 2015;Sundermann et al, 2014;Sutcubasi et al, 2020).…”

Section: Discussionsupporting

confidence: 90%

Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

Vilgis

Yee

Silk

et al. 2021

Preprint

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Working memory deficits are common in attention-deficit/hyperactivity disorder (ADHD) and depression, two common neurodevelopmental disorders with overlapping cognitive profiles but distinct clinical presentation. Multivariate techniques have previously been utilized to understand working memory processes in functional brain networks in healthy adults, but have not yet been applied to investigate how working memory processes within the same networks differ within typical and atypical developing populations. We used multivariate pattern analysis (MVPA) to identify whether brain networks discriminated between spatial vs. verbal working memory processes in ADHD and Persistent Depressive Disorder (PDD). 36 male clinical participants and 19 typically developing (TD) boys participated in a fMRI scan while completing a verbal and a spatial working memory task. Within a priori functional brain networks (frontoparietal, default mode, salience) the TD group demonstrated differential response patterns to verbal and spatial working memory. Both clinical groups show less differentiation than TD, with neural profiles suggesting ADHD is associated with weaker differentiation in both frontoparietal and salience networks and PDD is associated with weaker differentiation in left frontoparietal and default mode networks. Both clinical groups show less differentiation than TD, with neural profiles suggesting ADHD is associated with weaker differentiation in both frontoparietal and salience networks and PDD is associated with weaker differentiation in left frontoparietal and default mode networks. Whereas the TD group's neural profile indicates network response patterns that are sensitive to task demands, the neural profiles of the ADHD and PDD group suggest less specificity in neural representations of spatial and verbal working memory.

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Section: Discussionsupporting

confidence: 90%

Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

Vilgis

Yee

Silk

et al. 2021

Preprint

Self Cite

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“…This tight coupling might underlie decreased reciprocal inhibition between the anterior parts of these antagonistic networks. Moreover, the fact that the strongest DMN disinhibition was detected in the amPFC underlines the superior role of this cortical midline structure in the dynamic interplay between several large-scale neural circuitries, encompassing the fronto-parietal central executive network, cingulo-opercular salience network (SN), and the medial prefrontal-medial parietal DMN, which has been shown to be dysfunctional in depression ( Lemogne et al., 2012; Li et al., 2013; Liston et al., 2014 ) and other major neuropsychiatric disorders ( Meyer-Lindenberg and Tost, 2012; Chen et al., 2013; Vilgis et al., 2014 ). In detail, the present findings are in line with the idea that a dysfunctional amPFC interferes with bottom-up processes during WM-related computations in MDD patients.…”

Section: Discussionmentioning

confidence: 99%

Reduced default mode network suppression during a working memory task in remitted major depression

Bartova

Meyer

Diers

et al. 2015

Journal of Psychiatric Research

101

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Insufficient default mode network (DMN) suppression was linked to increased rumination in symptomatic Major Depressive Disorder (MDD). Since rumination is known to predict relapse and a more severe course of MDD, we hypothesized that similar DMN alterations might also exist during full remission of MDD (rMDD), a condition known to be associated with increased relapse rates specifically in patients with adolescent onset. Within a cross-sectional functional magnetic resonance imaging study activation and functional connectivity (FC) were investigated in 120 adults comprising 78 drug-free rMDD patients with adolescent- (n = 42) and adult-onset (n = 36) as well as 42 healthy controls (HC), while performing the n-back task. Compared to HC, rMDD patients showed diminished DMN deactivation with strongest differences in the anterior-medial prefrontal cortex (amPFC), which was further linked to increased rumination response style. On a brain systems level, rMDD patients showed an increased FC between the amPFC and the dorsolateral prefrontal cortex, which constitutes a key region of the antagonistic working-memory network. Both whole-brain analyses revealed significant differences between adolescent-onset rMDD patients and HC, while adult-onset rMDD patients showed no significant effects. Results of this study demonstrate that reduced DMN suppression exists even after full recovery of depressive symptoms, which appears to be specifically pronounced in adolescent-onset MDD patients. Our results encourage the investigation of DMN suppression as a putative predictor of relapse in clinical trials, which might eventually lead to important implications for antidepressant maintenance treatment.

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“…Altered frontal activation ACC/MPFC/OFC/ hyperactivation for happy faces (Keedwell et al, 2005a, b;Mitterschiffthaler et al, 2003;Zhang et al, 2013), reward anticipation and reward outcomes (Dichter et al, 2012) (Niendam et al, 2012) Working memory and selective attention (Chen et al, 2013;Niendam et al, 2012) DLPFC/ACC hypoactivation in MDD (Elliott et al, 1997;Holmes & Pizzagalli, 2008;Korgaonkar et al, 2013;Siegle et al, 2007;Vasic, Walter, Sambataro, & Wolf, 2009;Vilgis et al, 2014) and in social anxiety (Koric et al, 2012) and induced anxious mood (Fales et al, 2008).…”

Section: Structural Alterations In Depression and Anxietymentioning

confidence: 99%

Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: a theoretical review of the evidence and future directions for clinical translation

2016

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Complex emotional, cognitive and self-reflective functions rely on the activation and connectivity of large-scale neural circuits. These circuits offer a relevant scale of focus for conceptualizing a taxonomy for depression and anxiety based on specific profiles (or biotypes) of neural circuit dysfunction. Here, the theoretical review first outlined the current consensus as to what constitutes the organization of large-scale circuits in the human brain identified using parcellation and meta-analysis. The focus is on neural circuits implicated in resting reflection (“default mode”), detection of “salience”, affective processing (“threat” and “reward”), “attention” and “cognitive control”. Next, the current evidence regarding which type of dysfunctions in these circuits characterize depression and anxiety disorders was reviewed, with an emphasis on published meta-analyses and reviews of circuit dysfunctions that have been identified in at least two well-powered case:control studies. Grounded in the review of these topics, a conceptual framework is proposed for considering neural circuit-defined “biotypes”. In this framework, biotypes are defined by profiles of extent of dysfunction on each large-scale circuit. The clinical implications of a biotype approach for guiding classification and treatment of depression and anxiety is considered. Future research directions will develop the validity and clinical utility of a neural circuit biotype model that spans diagnostic categories and helps to translate neuroscience into clinical practice in the real world.

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Frontoparietal function in young people with dysthymic disorder (DSM-5: Persistent depressive disorder) during spatial working memory

Cited by 24 publications

References 79 publications

Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

Distinct Neural Profiles of Frontoparietal Networks in Boys with ADHD and Boys with Persistent Depressive Disorder

Reduced default mode network suppression during a working memory task in remitted major depression

Defining biotypes for depression and anxiety based on large-scale circuit dysfunction: a theoretical review of the evidence and future directions for clinical translation

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