Fronto-temporal galanin modulates impulse control

Messanvi, Fany; Perkins, Aster; Hoffmann, Johann du; Chudasama, Yogita

doi:10.1007/s00213-019-05365-2

Cited by 6 publications

(6 citation statements)

References 85 publications

(70 reference statements)

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“…Finally, rs1893824 ( p -value = 1.66 × 10 −6 , θ regression coefficient = −0.05 “better”) was identified as an eQTL of the gene in its vicinity, GALR1 (Galanin receptor type 1), in the anterior cingulate cortex ( Figure S8 ). GALR1 is a receptor for the hormone galanin with the highest expression level in the adenohypophysis [ 47 ], and there is evidence supporting that this receptor modulates impulse control in prefrontal-hippocampal circuitry [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band

et al. 2020

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Brain waves, measured by electroencephalography (EEG), are a powerful tool in the investigation of neurophysiological traits and a noninvasive and cost-effective alternative in the diagnostic of some neurological diseases. In order to identify novel Quantitative Trait Loci (QTLs) for brain wave relative power (RP), we collected resting state EEG data in five frequency bands (δ, θ, α, β1, and β2) and genome-wide data in a cohort of 105 patients with late onset Alzheimer’s disease (LOAD), 41 individuals with mild cognitive impairment and 45 controls from Iberia, correcting for disease status. One novel association was found with an interesting candidate for a role in brain wave biology, CLEC16A (C-type lectin domain family 16), with a variant at this locus passing the adjusted genome-wide significance threshold after Bonferroni correction. This finding reinforces the importance of immune regulation in brain function. Additionally, at a significance cutoff value of 5 × 10−6, 18 independent association signals were detected. These signals comprise brain expression Quantitative Loci (eQTLs) in caudate basal ganglia, spinal cord, anterior cingulate cortex and hypothalamus, as well as chromatin interactions in adult and fetal cortex, neural progenitor cells and hippocampus. Moreover, in the set of genes showing signals of association with brain wave RP in our dataset, there is an overrepresentation of loci previously associated with neurological traits and pathologies, evidencing the pleiotropy of the genetic variation modulating brain function.

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Section: Resultsmentioning

confidence: 99%

Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band

et al. 2020

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“…Cognitive testing using touchscreen technology with animal models, especially rodents, is currently used in over 400 research groups at over 200 research institutes in at least 26 countries 19 . Such popularity has resulted in prolific research outcomes that are increasing exponentially [38][39][40][41][42][43][44][45][46][47][48][49] . As Fig.…”

Section: Discussionmentioning

confidence: 99%

Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes+

et al. 2023

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Open access to rodent cognitive data has lagged behind the rapid generation of large open-access datasets in other areas of neuroscience, such as neuroimaging and genomics. One contributing factor has been the absence of uniform standardization in experiments and data output, an issue that has particularly plagued studies in animal models. Touchscreen-automated cognitive testing of animal models allows standardized outputs that are compatible with open-access sharing. Touchscreen datasets can be combined with different neuro-technologies such as fiber photometry, miniscopes, optogenetics, and MRI to evaluate the relationship between neural activity and behavior. Here we describe a platform that allows deposition of these data into an open-access repository. This platform, called MouseBytes, is a web-based repository that enables researchers to store, share, visualize, and analyze cognitive data. Here we present the architecture, structure, and the essential infrastructure behind MouseBytes. In addition, we describe MouseBytes+, a database that allows data from complementary neuro-technologies such as imaging and photometry to be easily integrated with behavioral data in MouseBytes to support multi-modal behavioral analysis.

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“…Two weeks following stereotaxic placement of fiber implants (see below), rats were trained to accurately detect the occurrence of a brief visual target (a white square) in the 5-Choice attentional task using the touchscreen operant platform. Full details of the apparatus and behavioral procedure can be found in Messanvi et al (2020) [25]. Some adaptations to the apparatus were necessary to enable the optogenetic and fiber photometry settings.…”

Section: Behavioral Procedure: 5-choice Taskmentioning

confidence: 99%

“…Recently, we discovered that galanin, through local stimulation of galanin receptor type 1 (GalR1), affects cognitive control functions in rats through its direct actions in the ventral prefrontal cortex (vPFC) and the ventral hippocampus (vHC) [25]. The main change to behavior concerned the rate of impulsive premature responding.…”

Section: Introductionmentioning

confidence: 99%

Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control

Messanvi,

Visocky,

Senneca

et al. 2024

Preprint

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While amino acid neurotransmitters are the main chemical messengers in the brain, they are co-expressed with neuropeptides which are increasingly recognized as modulators of cognitive pathways. For example, the neuropeptide galanin has been implicated in a wide range of pathological conditions in which frontal and temporal structures are compromised. In a recent study in rats, we discovered that direct pharmacological stimulation of galanin receptor type 1 (GalR1) in the ventral prefrontal cortex (vPFC) and ventral hippocampus (vHC) led to opposing effects on attention and impulse control behavior. In the present study, we investigate how subtypes of neurons expressing GalR1 in these two areas differentially contribute to these behaviors. We first establish that GalR1 is predominantly expressed in glutamatergic neurons in both the vPFC and HC. We develop a novel viral approach to gain genetic access to GalR1-expressing neurons and demonstrate that optogenetic excitation of GalR1 expressing neurons in the vPFC, but not vHC, selectively disrupts attention in a complex behavioral task. Finally, using fiber photometry, we measure the bulk calcium dynamics in GalR1-expressing neurons during the same task to demonstrate opposing activity in vPFC and vHC. These results are consistent with our previous work demonstrating differential behavioral effects induced by GalR1 activating in vPFC and vHC. These results indicate the distinct neuromodulatory and behavioral contributions of galanin mediated by subclasses of neurons in the hippocampal and prefrontal circuitry.

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Fronto-temporal galanin modulates impulse control

Cited by 6 publications

References 85 publications

Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band

Genome-Wide Scan for Five Brain Oscillatory Phenotypes Identifies a New QTL Associated with Theta EEG Band

Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes+

Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control

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