Fronto‐parieto‐subthalamic activity decodes motor status in Parkinson's disease

Abstract

Eighty percent of patients with Parkinson's disease (PD) demonstrate dysfunctions in various motor status switches, such as difficulties in standing up, gait initiation, and freezing while walking. 1 These dysfunctions are the first intrinsic causes associated with falls and are closely related to cognitive impairment, often leading to restrictions in the patient's quality of life. [2][3][4] In addition, with disease progression, these dysfunctions are resistant to dopaminergic treatment and deep brain stimulation (DBS). 5,6 Therefore, revealing the neurophysiological patterns underlying different motor statuses, including sitting, standing, walking, dual-task walking, and freezing of gait, is essential for developing the optimized therapy.