Frontiers in inflammatory bowel disease

Shephard, David A. E.; Bartlett, John D.; Hofmann, Alan F.; Hd, Janowitz; Kern, Fred; Kirsner, Joseph B.; Kraft, Sumner C.; Mendeloff, A. L.; Phillips, Sidney F.; Sherlock, Paul; Shorter, Roy G.; Singleton, John W.; Stobo, John D.; Taylor, K. B.; Thayer, Walter R.; Watson, David

doi:10.1007/bf01074938

Cited by 8 publications

(1 citation statement)

References 138 publications

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“…Although IBD is associated with several immunological perturbations, there is no direct evidence indicating whether these alterations in the immune system are primary manifestations of disordered immunity or secondary abnormalities resulting from inflammation in the gastrointestinal tract (Shorter et al 1976). There is a growing confidence that new studies will yield information defining the immunopathogenesis of IBD (Markowitz andDaum 1991, Shorter andShephard 1975). A great deal of work has been done in the investigation of lymphocyte subpopulations in the human colon.…”

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confidence: 99%

Evaluation of B and T lymphocytes and plasma cells in colonic mucosa from healthy dogs and from dogs with inflammatory bowel disease

Stonehewer¹,

Simpson²,

Else³

et al. 1998

Research in Veterinary Science

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The aim of this study was to investigate the subpopulations of lymphocytes in the colonic mucosa of healthy dogs and dogs with inflammatory bowel disease (IBD). Fourteen normal dogs and 13 dogs with IBD were examined. Endoscopic biopsy specimens of colonic mucosa from each dog were stained specifically for pan T lymphocytes (CD3) and pan B lymphocytes (CD79a), and for plasma cells with methyl green pyronin (MGP) stain. Cells were counted by means of a grid and statistical analysis was performed on the data collected. B and T lymphocytes were also counted in the glandular epithelium of normal dogs and dogs with IBD and the normal and abnormal groups compared statistically. Healthy dogs had significantly lower numbers of T cells in the lamina propria and glandular epithelium and significantly lower numbers of B cells in the lamina propria. Significant group differences for plasma cells were not evident. Our results indicate that in IBD a chronic cellular immune reaction is present in the diseased gut involving increased numbers of B and T lymphocytes.

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confidence: 99%