Summary: Young normal subjects, old normal subjects, and patients with senile dementia of the Alzheimer's type (SDAT) were studied with both computed tomography (CT) and positron emission transaxial tomography (PETT). Increases in ventricular size with both aging and disease were measured. Regional glucose metabolic rate was not affected by age, but was markedly reduced in SDAT pa tients. These data indicate that in normal aging, structural brain changes may be more salient than biochemical Abbreviations used: CM, Canthomeatal; CT, computed to mography; FDG, 18F-2-deoxy-2-fluoro-D-glucose; GDS, Global Deterioration Scale; PETT, positron emission transaxial tomog raphy; SDAT, senile dementia of the Alzheimer's type. It is possible that a number of methodological variables, such as subject selection criteria and methods of scan analysis, may account for these