Frontal Hairline Recession: A Diagnostic Pitfall

Kelati, Awatef; Mernissi, Fatima Zahra

doi:10.1159/000454885

Cited by 2 publications

(4 citation statements)

References 4 publications

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“…A positive response is manifested as stabilization, i.e., cessation of hairline regression, or improvement, i.e., hair regrowth; a negative response is considered as progressive hairline recession [4]. Some authors define disease stabilization as the absence of inflammation on biopsy; however, biopsy is an invasive procedure and is not routinely performed [46,47].…”

Section: Treatmentmentioning

confidence: 99%

“…Some studies suggest that while TC use may result in stabilization in the early stages, discontinuation can be associated with relapse [17], and the treatment can also result in scalp skin atrophy, telangiectasia, erythema, or folliculitis [42,46]. In comparison, topical calcineurin inhibitors (TCIs) appear to have higher efficacy [47]. Patients receiving tacrolimus (0.3%) were more likely to achieve stabilization within 3 months compared to those treated with TCs [26].…”

Section: Anti-inflammatory Agents Corticosteroids/calcineurin Inhibitorsmentioning

confidence: 99%

“…ILTA is an FDA-approved medication used for managing diverse inflammatory conditions, including skin disorders such as discoid lupus, lichen planus, or alopecia areata. This drug is consistently recommended in all hair loss treatment guidelines and for FFA, and ILTA is acknowledged as one of the most effective therapeutic options so far [17,19,45,47,56]. As part of combination therapy, ILTA results in a favorable outcome in up to 84% of cases [42].…”

Section: Intralesional Treatment Intralesional Triamcinolone Acetonid...mentioning

confidence: 99%

“…To date, four cases of methotrexate monotherapy have been reported in FFA patients. Stabilization of the disease process was observed in only two of them [26,47,[100][101][102]. HT in FFA therapy remains controversial.…”

Section: Methotrexatementioning

confidence: 99%

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The Frontal Fibrosing Alopecia Treatment Dilemma

Krzesłowska,

Woźniacka

2024

JCM

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Frontal fibrosing alopecia (FFA) is a type of cicatricial alopecia predominantly observed in postmenopausal women, with the incidence rising since its initial description in 1994. The exact etiopathogenesis of the disease has not been completely elucidated. FFA is characterized by an inflammatory process affecting the hair follicles of the fronto-temporal hairline, leading to its gradual recession. Eyebrows, particularly the lateral parts, may also be affected. Early diagnosis and an implementation of effective therapy to limit the inflammatory process are crucial in halting disease progression. Various treatment possibilities have been reported, including anti-inflammatory and immunosuppressive agents, as well as 5-alpha-reductase inhibitors, retinoids, and antimalarial agents. The use of phototherapy and surgical procedures has also been described. However, most available data have been obtained retrospectively, frequently consisting of descriptions of case reports or small case series, and not from randomized controlled trials. In addition, the etiopathogenesis of FFA remains unclear and its course unpredictable, occasionally being linked with spontaneous stabilization. Hence, no precise guidelines exist regarding treatment modalities. Therefore, the aims of this study were to provide a comprehensive review of the efficacy of existing therapeutic modalities for FFA and to highlight novel therapeutic options.

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Section: Treatmentmentioning

confidence: 99%