Frontal fibrosing alopecia

Kerkemeyer, Karolina Louisa Suzanna; Eisman, Samantha; Bhoyrul, Bevin; Pinczewski, Joel; Sinclair, Rodney

doi:10.1016/j.clindermatol.2020.10.007

Cited by 15 publications

(14 citation statements)

References 87 publications

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“…In the venerable history of LPP/FFA pathogenesis discussions ( Baibergenova and Donovan, 2013 ; Harries et al., 2018 ; Headington, 1996 ; Kang et al., 2008 ; Kerkemeyer et al., 2021 ; Tziotzios et al., 2016 ), many different potential triggering or aggravating factors besides trauma have been implicated. It remains a wide-open question whether, where, and to which extent the factors discussed in the following sections and listed in Table 2 exert and possibly coalesce in any epigenetic changes that affect LPP/FFA pathogenesis (regrettably, the epigenetic pathology of PCAs essentially is terra incognita).…”

Section: Other Factorsmentioning

confidence: 99%

Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons

et al. 2022

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Section: Other Factorsmentioning

confidence: 99%

Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons

et al. 2022

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“…In contrast, FFA is believed to have an autoimmune etiology, primarily affecting older adults, notably post-menopausal women. FFA shares similar clinical features with KPAF, including bilateral eyebrow loss (madarosis), perifollicular erythema, follicular hyperkeratosis (noted in the frontal hairline rather than eyebrows), and facial follicular flesh-colored papules, but it is differentiated by a receding frontal hairline (Table 1 ) [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Navigating Diagnostic Uncertainty: Frontal Fibrosing Alopecia Versus Keratosis Pilaris Atrophicans Faciei With Genetic Testing Insights

Desai,

Nohria,

Shapiro

et al. 2024

Cureus

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Keratosis pilaris atrophicans faciei (KPAF) and frontal fibrosing alopecia (FFA) present diagnostic challenges due to their similar clinical characteristics. Dermatologists often employ overlapping treatment regimens, which may hinder accurate diagnosis and treatment expectations. Genetic testing offers promise for precise diagnosis and tailored treatment strategies, yet its utility in these conditions remains underexplored. This manuscript presents a unique case study of a 36-year-old male with symptoms of both KPAF and FFA, who underwent genetic testing. Despite testing negative for this mutation, the case underscores the potential of genetic testing to enhance diagnostic accuracy and optimize treatment outcomes.

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“…Trichoscopy shows the presence of residual isolated terminal hairs and the absence of vellus hairs. Perifollicular erythema with perifollicular scaling due to follicular hyperkeratosis are important features 15,16 …”

Section: Discussionmentioning

confidence: 99%

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

Qiao,

Zhu,

Liu

et al. 2023

Int J Dermatology

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BackgroundLonely hair sign is considered as a clue to the diagnosis of frontal fibrosing alopecia (FFA).ObjectiveTo report an undescribed variant of alopecia areata (AA) with which the patient developed single hairs and other features similar to FFA and to determine the underlying mechanism.MethodsWe conducted a prospective observational study in patients who presented with receding hairline and single hairs, evaluating the clinical, trichoscopic, and histological features and their correlation. Immunochemistry studies were performed to describe the microenvironment.ResultsEighteen patients were enrolled in the study. Despite the similarity to FFA clinically, these patients showed different histopathology which revealed a normal number of pilosebaceous units, one anagen hair in one or more pilosebaceous units, and others in telogen stage, consistent with single hairs under the naked eye or under trichoscopy. The severity of the hair loss assessed by SALT was no more than 50, but the response to conventional therapy was poor.ConclusionsThis study reports a unique variant of AA. The pathological basis is an increase in the telogen hair follicles, with one anagen hair in one or more pilosebaceous units. Minimal inflammation consisting of CD3+ T lymphocytes and mast cells was demonstrated in the microenvironment.

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Frontal fibrosing alopecia

Cited by 15 publications

References 87 publications

Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons

Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons

Navigating Diagnostic Uncertainty: Frontal Fibrosing Alopecia Versus Keratosis Pilaris Atrophicans Faciei With Genetic Testing Insights

Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

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