Frontal fibrosing alopecia: treatment with oral dutasteride and topical pimecrolimus

Abstract

Figure 1 Multiple, depigmented macules under the henna tattoo over the dorsum of left hand.

Primary cicatricial alopecia: diagnosis and treatment

“…The use of antiandrogens and calci neurin inhibitors has also been advocated. 21 Recently, the asebia mouse, with an autosomal recessive trait resulting in hypoplastic sebaceous glands, has been shown to develop hair loss that shares many features with lichen planopilaris. 3 The mouse develops a progressive alopecia with sparse or matted hair, pruritus and scaly skin that shares many clinical and histological features with primary cicatricial alopecia.…”

“…10 Cases are classified as lymphocytic, neutrophilic or mixed (Table 1). 5,6,9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In end-stage disease, in which the infiltrate is no longer detectible, the condition is said to be "burned out," and no further classification is possible.…”

Alopecia frontal fibrosante: relato de caso

“…These clinical conditions are considered typical of . Laboratorial investigation as mentioned in the literature such as CBC (Complete Blood Count), serum parameters of sexual hormones, TSH, antithyroid hormones, FAN, VDRL and anti-DNA, were always either negative or normal 2,6,7,8,9,12 . Histopathologic analysis frequently shows lymphocytic infiltrate, around the pilary follicles, with lichenoid reaction, noticeble reduction in the number of follicles and fibrosis.…”

“…Frontal fibrosing alopecia is a form of slowly progressive alopecia,varying from one to ten years, and cicatricial that presents symmetrical retreat from the frontal and temporal borders of the hair implantation 7,8,12,13 . There is only one case described in the medical literature of development on the posterior occipital line.…”

Frontal Fibrosing Alopecia

“…Hair regrowth in an exceedingly scarring phalacrosis within which destruction of hair follicles could be a cardinal histopathological characteristic [2,7] is a perplexing phenomenon. Nonetheless, individual expertise and documented instances have established improvement in brow progress in some FFA patients handled with topical calcineurin inhibitors [33]. During a similar fashion, regrowth of hair in apparently scarred areas of scalp in chronic circular autoimmune disease (CDLE) and different scarring alopecias is sometimes found [34,35].…”