Frontal brain activation in premature infants' response to auditory stimuli in neonatal intensive care unit

Saito, Yasufumi; Fukuhara, Rie; Aoyama, Shiori; Toshima, Tamotsu

doi:10.1016/j.earlhumdev.2009.04.004

Cited by 32 publications

(37 citation statements)

References 19 publications

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“…The left IFG landmark is near the cortical location of Broca's area, a critical node in the language network. The frontal pole landmark consisted of the most anterior location on the cerebral cortex, and was typically located near the intersection of superior frontal gyrus and the orbital gyri, relevant for frontal and prefrontal fNIRS studies of cognition [22], [23], [26], [29], [32], [40], [56], [57], [58], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80].…”

Section: Methodsmentioning

confidence: 99%

The Developmental Trajectory of Brain-Scalp Distance from Birth through Childhood: Implications for Functional Neuroimaging

et al. 2011

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Measurements of human brain function in children are of increasing interest in cognitive neuroscience. Many techniques for brain mapping used in children, including functional near-infrared spectroscopy (fNIRS), electroencephalography (EEG), magnetoencephalography (MEG) and transcranial magnetic stimulation (TMS), use probes placed on or near the scalp. The distance between the scalp and the brain is a key variable for these techniques because optical, electrical and magnetic signals are attenuated by distance. However, little is known about how scalp-brain distance differs between different cortical regions in children or how it changes with development. We investigated scalp-brain distance in 71 children, from newborn to age 12 years, using structural T1-weighted MRI scans of the whole head. Three-dimensional reconstructions were created from the scalp surface to allow for accurate calculation of brain-scalp distance. Nine brain landmarks in different cortical regions were manually selected in each subject based on the published fNIRS literature. Significant effects were found for age, cortical region and hemisphere. Brain-scalp distances were lowest in young children, and increased with age to up to double the newborn distance. There were also dramatic differences between brain regions, with up to 50% differences between landmarks. In frontal and temporal regions, scalp-brain distances were significantly greater in the right hemisphere than in the left hemisphere. The largest contributors to developmental changes in brain-scalp distance were increases in the corticospinal fluid (CSF) and inner table of the cranium. These results have important implications for functional imaging studies of children: age and brain-region related differences in fNIRS signals could be due to the confounding factor of brain-scalp distance and not true differences in brain activity.

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Section: Methodsmentioning

confidence: 99%

The Developmental Trajectory of Brain-Scalp Distance from Birth through Childhood: Implications for Functional Neuroimaging

et al. 2011

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“…Recent successes using functional near infrared spectroscopy (fNIRS) (Hebden, 2003; Yodh and Boas, 2003; Steinbrink et al, 2006) to study neonatal auditory and language development (Gervain et al, 2008; Saito et al, 2009) and pain responses (Bartocci et al, 2006) highlight the promise of extending fNIRS neuroimaging into populations that are difficult to scan with functional magnetic resonance imaging (fMRI). fNIRS uses near infrared sources and detectors to measure changes in absorption due neurovascular dynamics in response to brain activation, which allows a combination of portable instrumentation, wearable imaging caps, and more comprehensive hemodynamic imaging contrasts.…”

Section: Introductionmentioning

confidence: 99%

Brain specificity of diffuse optical imaging: improvements from superficial signal regression and tomography

et al. 2010

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Functional near infrared spectroscopy (fNIRS) is a portable monitor of cerebral hemodynamics with wide clinical potential. However, in fNIRS, the vascular signal from the brain is often obscured by vascular signals present in the scalp and skull. In this paper, we evaluate two methods for improving in vivo data from adult human subjects through the use of high-density diffuse optical tomography (DOT). First, we test whether we can extend superficial regression methods (which utilize the multiple source–detector pair separations) from sparse optode arrays to application with DOT imaging arrays. In order to accomplish this goal, we modify the method to remove physiological artifacts from deeper sampling channels using an average of shallow measurements. Second, DOT provides three-dimensional image reconstructions and should explicitly separate different tissue layers. We test whether DOT's depth-sectioning can completely remove superficial physiological artifacts. Herein, we assess improvements in signal quality and reproducibility due to these methods using a well-characterized visual paradigm and our high-density DOT system. Both approaches remove noise from the data, resulting in cleaner imaging and more consistent hemodynamic responses. Additionally, the two methods act synergistically, with greater improvements when the approaches are used together.

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“…Early NIRS studies examined infants who were presented with stimuli while they were asleep (Aoyama et al, 2010;Homae et al, 2007;Saito et al, 2007aSaito et al, , 2007bSaito et al, , 2009). …”

Section: Functional Brain Activity In Infantsmentioning

confidence: 99%

Near-Infrared Spectroscopic Assessment of Haemodynamic Activation in the Cerebral Cortex - A Review in Developmental Psychology and Child Psychiatry

Kaneko¹,

Yoshikawa²,

Ito³

et al. 2012

Infrared Spectroscopy - Life and Biomedical Sciences

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Frontal brain activation in premature infants' response to auditory stimuli in neonatal intensive care unit

Cited by 32 publications

References 19 publications

The Developmental Trajectory of Brain-Scalp Distance from Birth through Childhood: Implications for Functional Neuroimaging

The Developmental Trajectory of Brain-Scalp Distance from Birth through Childhood: Implications for Functional Neuroimaging

Brain specificity of diffuse optical imaging: improvements from superficial signal regression and tomography

Near-Infrared Spectroscopic Assessment of Haemodynamic Activation in the Cerebral Cortex - A Review in Developmental Psychology and Child Psychiatry

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