From Traditional Herbal Medicine to Rational Drug Discovery: Strategies, Challenges, and Future Perspectives

Singh, Dev Bukhsh; Pathak, Rajesh Kumar; Rai, Dipti

doi:10.1007/s43450-022-00235-z

Cited by 17 publications

(12 citation statements)

References 71 publications

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“…Although synthetic medicine has advanced significantly over the past few decades, most individuals still prefer herbal medicine. [1] Furthermore, phytochemicals can have therapeutic effects or be a starting compound for developing new medicinal compounds. [2] Traditional medicine places a great deal of emphasis on herbal therapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…Since ancient times, they have been used to treat diseases due to these properties. Although synthetic medicine has advanced significantly over the past few decades, most individuals still prefer herbal medicine [1] . Furthermore, phytochemicals can have therapeutic effects or be a starting compound for developing new medicinal compounds [2] .…”

Section: Introductionmentioning

confidence: 99%

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Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

Çomaklı¹,

Kaya²,

Kuzu³

et al. 2023

Chemistry & Biodiversity

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In the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus officinalis L. were obtained by maceration. DPPH⋅, ABTS⋅+, FRAP, and CUPRAC methods determined the antioxidant capacities of all extracts. Moreover, the in vitro effects of extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA)‐I, CA‐II and α‐Glycosidase were investigated. At a 10 μg/ml concentration, the extract with the highest Fe3+ reduction capacity was ethanol (AE), and the extract with the highest Cu2+ reduction capacity was acetone (AA). AE for AChE (IC50=21.19 μg/ml) and α‐Glycosidase (IC50: 70.00 μg/ml), methanol (AM) for BChE (IC50=17.33 μg/ml), CA−I and II (IC50=79.65 and 36.09 μg/ml, respectively) showed the most potent inhibition effect. The content analysis of acetone extract was performed with LC/MS‐MS, the first three phytochemicals found most were p‐Coumaric acid, rutin, and 4‐hydroxybenzoic acid (284.29±3.97, 135.39±8.19, and 102.06±5.51 μg analyte/g extract, respectively).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

Çomaklı¹,

Kaya²,

Kuzu³

et al. 2023

Chemistry & Biodiversity

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“…Herbal medicines have been historically used for their therapeutic benefits and have attracted renewed interest among researchers. [1,2] The exploration of natural compounds derived from plants has led to the discovery of numerous bioactive substances that serve as promising candidates for drug development. [3][4][5] Despite these advancements, a significant portion of the world's biodiversity remains unexplored, leaving a vast potential for the discovery of novel bioactive natural agents.…”

Section: Introductionmentioning

confidence: 99%

“…Herbal medicines have been historically used for their therapeutic benefits and have attracted renewed interest among researchers [1,2] . The exploration of natural compounds derived from plants has led to the discovery of numerous bioactive substances that serve as promising candidates for drug development [3–5] .…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Diep,

Dung,

Trung

et al. 2023

Chemistry & Biodiversity

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This study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti‐inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty‐four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)‐carpacin (17.6 %), 2‐tridecanone (12.2 %), and 9‐methyl‐2‐decanone (11.8 %) were the most abundant. The stem oil contained fifty‐five identified constituents, mainly γ‐gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS‐induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK‐LU‐1, MCF‐7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti‐inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium.

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“…The search for additional alternative, safe, and low-cost treatments stems from the fact that despite the shift from herbal medicine to modern approaches of drug design and the new developments in research techniques in many fields like genomics, proteomics, biochemistry, and the use of computer tools, a large population of the world is still relying on the herbal medicine system. 13 This work describes the effects of E. japonica seeds, leaves, and fruit ethanolic extract on body weight, lipid profile, glucose level as well as liver and kidney enzymes.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

Abdelrahman

Bustanji

Abdalla

2022

Pharmacognosy Magazine

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Background: Obesity is a serious public health problem contributing to development of several diseases, including hyperlipidemia, hyperglycemia, and hypertension. The plant Eriobotrya japonica (loquat) has been used in traditional Chinese medicine to treat many ailments and traditional healers used it to reduce weight. Objective: To examine the potential anti-obesity and hypolipidemic effects of ethanol extract of loquat in rats. Materials and Methods: Loquat leaves, fruits, or seeds were extracted with ethanol. About 96 Wistar male rats were fed either a normal rat diet (normal control group; group 1) or a high-fat diet (HFD) for 12 weeks (obese; groups 2−12). Obese rats were divided into11 groups as follows: (obese control: group 2) (obese positive control which received the hypolipidemic reference drug atorvastatin: group 3). Groups (4−6), (7−9), and (10−12) were given seed, leaf, or fruit extract, respectively, at 40,100, and 400 mg/kg. Body weight, serum glucose, lipid profile, creatinine, liver enzymes, albumin, and total protein were measured weekly. Results: HFD consumption significantly increased body weight and serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very-low density lipoprotein (VLDL), and glucose and decreased HDL compared to rats fed the normal diet. HFD also increased serum glutamic-oxaloacetic transaminase (GOT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and creatinine but decreased serum albumin and total protein. Administration of E. japonica seed, leaf, or fruit extract significantly decreased body weight, TC, TGs, LDL, VLDL, glucose, liver, and renal enzymes but increased HDL, albumin, and total protein levels. Conclusion: E. japonica seed, leaf, and fruit ethanol extract regulates body weight gain, has hypolipidemic properties, and positively affects liver and kidney enzymes.

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From Traditional Herbal Medicine to Rational Drug Discovery: Strategies, Challenges, and Future Perspectives

Cited by 17 publications

References 71 publications

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam

Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

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