From shaping to functionalization of micro-droplets and particles

Abstract

From shaping to functionalization of micro-droplets and particles in passive and active methods, and their applications.

Microfluidic Particle Reactors: From Interface Characteristics to Cells and Drugs Related Biomedical Applications

“…[ 1–3 ] Researchers have been able to flexibly design and prepare different MPRs with the required structures and interface characteristics as expected, such as particles, colloidosomes, vesicles, gel‐microspheres, and multiple polymersomes. [ 4,5 ] The remarkable interface characteristics, endowing the mentioned MPRs with advanced functions, [ 6 ] can be attributed to two aspects. 1) The exquisite control and manipulation abilities of fluids at a microscale have reached a new height as droplet microfluidic technology is leaping forward.…”

“…[1][2][3] Researchers have been able to flexibly design and prepare different MPRs with the required structures and interface characteristics as expected, such as particles, colloidosomes, vesicles, gel-microspheres, and multiple polymersomes. [4,5] The remarkable interface characteristics, endowing the mentioned MPRs…”

“…Recently, the types, preparation methods, and biomedical applications of MPRs have been systematically presented in several excellent reviews. [3][4][5][8][9][10][17][18][19][20] The thermodynamic properties of liquid-liquid droplet reactors have been analyzed more specifically in some reviews. [7,17] However, the origin of interface characteristics of MPRs, as well as the function and cuttingedge cell-and drug-related biomedical applications determined by the interface characteristics, are deficient in a systematic summary.…”

Producing shape-engineered alginate particles using viscoplastic fluids

“…Hydrogel particles are hydrated 3D networks of crosslinked polymer chains that have found diverse application in the biomedical, pharmaceutical, environmental, food, and cosmetic industries due to their versatile nature with highly tunable physical and chemical properties. [1][2][3][4][5] Hydrogel particles are extensively used for controlled drug delivery, [6][7][8] cell and islet encapsulation, [9][10][11][12] scaffold building and 3D biofabrication, 13,14 biosensing, 15 bioactive delivery in aquaculture, 16 and water treatment. 17 Hydrogels can be made of both natural and synthetic polymers.…”

Water promoted 9-fluorenylmethyloxycarbonyl detachment from amino acids in charged microdroplets

“…Microdroplet chemistry has aroused widespread interest in the last few decades, [1][2][3][4][5][6] and it appears to be an effective platform for various types of organic reactions, such as condensation reactions, [7][8][9] elimination and substitution reactions, 3 rearrangement reactions, 10 noncovalent complexations 11 and some other reactions. [12][13][14] In particular, water related microdroplet chemistry is receiving increasing attention.…”