“From safe source to safe sink” development of colorimetric assay for gabapentin in bulk drug and capsules using naturally derived genipin

Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

“…The limits of detection (LOD) and quantication (LOQ) were found to be 0.1600 and 0.4801 mg mL −1 , respectively. The results of this sensor transcended some reported methods for gabapentin detection, particularly the spectrophotometric methods, 28,30 in terms of sensitivity and linearity. Furthermore, the linearity and sensitivity of the developed sensor were comparable to some chromatographic methods and reported spectrouorometric methods without the need for the extra derivatization reactions for gabapentin detection.…”

“…26,27 However, these techniques have drawbacks such as the need for derivatization to create a detectable chromophore or they oen require expensive equipment, skilled operators, and time-consuming sample preparation procedures. Alternative methods like UV visible spectrophotometry [28][29][30] and spectrouorimetry [31][32][33] have been also explored for gabapentin analysis but still face limitations due to the extra derivatization step required for gabapentin detection due to the lack of chromophoric group. To overcome these challenges, there is a growing interest in developing more accessible, cost-effective, and rapid detection methods for gabapentin that do not require additional steps like derivatization.…”