From Probiotics to Postbiotics: Key to Microbiome and Health

Walhe, Rajan; Khan, Hina; Kumari, Sunita

doi:10.1007/978-981-16-1626-6_18

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Probiotics are mostly lactic acid bacteria (Walhe et al, 2022) and have many health benefits; however, because they are alive, they have limitations for use and treatment. Probiotic bacteria must maintain their viability even in inappropriate conditions, such as preparation of food, storage, processing, distribution as well as passing through the digestive system, so that they can perform their health-giving effects (Homayouni-Rad et al, 2020;Rad et al, 2020a).…”

Section: Search Strategymentioning

confidence: 99%

A systematic review to introduce the most effective postbiotics derived from probiotics for aflatoxin detoxification in vitro

Zamanpour,

Ali Noori,

Shokrollahi Yancheshmeh

et al. 2023

Ital. J. Food Sci.

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The purpose of this study was to gather information about the percentage of aflatoxin decontamination by postbiotics and to find the most effective postbiotic. In this review article, studies were collected from databases. All the articles related to experimental studies were included in the study. It appeared that the postbiotics derived from Lentilactobacillus kefiri, Lentilactobacillus kefiri, Lacticaseibacillus rhamnosum, Lacticaseibacillus rhamnosum and Pediococcus pentosaceus probiotic bacteria were the most effective postbiotics with 97.22%, 95.27%, 86.2%, 81.4% and 91% inhibitory effect against aflatoxins B1, B2, G1, G2 and M1, respectively. Therefore, postbiotics could be used as safe anti-aflatoxin agents in food products.

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Section: Search Strategymentioning

confidence: 99%

A systematic review to introduce the most effective postbiotics derived from probiotics for aflatoxin detoxification in vitro

Zamanpour,

Ali Noori,

Shokrollahi Yancheshmeh

et al. 2023

Ital. J. Food Sci.

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“…Indeed, health-promoting features do not depend only on metabolically active, viable microbial cells, as they may also be ascribed to probiotic-derived molecules [6][7][8], including the mixture of metabolites secreted into the culture medium, often referred to as cell-free culture supernatants (CFS) [9,10], or released together with cell structural components, upon cell lysis or inactivation [11,12]. Interestingly, probiotic-derived molecules often share the same health potential as probiotics and, additionally, have some advantages over the limitations of the latter [13]. In this light, the study of the immunomodulatory properties of CFS provides insight into the probiotic behaviour, but also preliminary information concerning a postbiotic potential.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity on Human Macrophages by Cell-Free Supernatants to Explore the Probiotic and Postbiotic Potential of Lactiplantibacillus plantarum Strains of Plant Origin

Rocchetti

Russo

Simone

et al. 2023

Probiotics & Antimicro. Prot.

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Upon dietary administration, probiotic microorganisms can reach as live cells the human gut, where they interact with the microbiota and host cells, thereby exerting a beneficial impact on host functions, mainly through immune-modulatory activities. Recently, attention has been drawn by postbiotics, i.e. non-viable probiotic microbes, including their metabolic products, which possess biological activities that benefit the host. Lactiplantibacillus plantarum is a bacterial species that comprises recognised probiotic strains. In this study, we investigated in vitro the probiotic (and postbiotic) potential of seven L. plantarum strains, including five newly isolated from plant-related niches. The strains were shown to possess some basic probiotic attributes, including tolerance to the gastrointestinal environment, adhesion to the intestinal epithelium and safety. Besides, their cell-free culture supernatants modulated cytokine patterns in human macrophages in vitro, promoting TNF-α gene transcription and secretion, while attenuating the transcriptional activation and secretion of both TNF-α and IL-8 in response to a pro-inflammatory signal, and enhancing the production of IL-10. Some strains induced a high IL-10/IL-12 ratio that may correlate to an anti-inflammatory capacity in vivo. Overall, the investigated strains are good probiotic candidates, whose postbiotic fraction exhibits immunomodulatory properties that need further in vivo studies. The main novelty of this work consists in the polyphasic characterisation of candidate beneficial L. plantarum strains obtained from relatively atypical plant-associated niches, by an approach that explores both probiotic and postbiotic potentials, in particular studying the effect of microbial culture-conditioned media on cytokine pattern, analysed at both transcriptional and secretion level in human macrophages.

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“…Probiotics are mostly lactic acid bacteria [114] and have many health bene ts, however, because they are alive, they have limitations for use and treatment. Probiotic bacteria must maintain their viability in inappropriate conditions such as preparation, storage, processing, distribution, and digestive system stages so that they can perform their health-giving effects [55,90].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review to Introduce the Most Effective Postbiotic Derived from Probiotics for Aflatoxin Detoxifications

Zamanpour

Noori

Yancheshmeh

et al. 2023

Preprint

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Introduction: Aflatoxins are one of the most dangerous mycotoxins that have created challenges in the field of food safety. Different chemical, biological, and physical techniques were studied to detoxify aflatoxins in vegetable and animal foods. Among the biological methods is microbial detoxification. Some microorganisms, especially probiotic bacteria, play a key role in reduction of aflatoxin. Simultaneously with the remarkable progress in this field, the researchers got acquainted with the new concept of postbiotics, which explains to some extent the exact mechanism of detoxification of probiotics. The purpose of this study is to find the aflatoxin removal percentage by postbiotics and to find the most effective postbiotic. Materials and Methods: In this review article, studies that tested the effect of probiotics-derived postbiotics on aflatoxin detoxification in vitro were collected from databases. All the articles related to experimental studies were included in the study and the articles without full text or were not consistent with our study were excluded from the study. Results: It seems that out of all the postbiotics under investigation, the postbiotic derived from Lactobacillus kefiri, Lactobacillus kefiri, Lactobacillus rhamnosus, Lactobacillus rhamnosus, Saccharomyces cerevisiae probiotic bacteria is the most effective postbiotic with 97.22%, 95.27%, 86.2%, 81.4%, and 100% inhibitory effect against Aflatoxin B1, B2, G1, G2, and M1. Conclusion(s): Therefore, postbiotics derived from probiotic bacteria can be used as a safe anti-aflatoxin agent in a wide range of food products to control toxins and promote health.

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From Probiotics to Postbiotics: Key to Microbiome and Health

Cited by 5 publications

References 26 publications

A systematic review to introduce the most effective postbiotics derived from probiotics for aflatoxin detoxification in vitro

A systematic review to introduce the most effective postbiotics derived from probiotics for aflatoxin detoxification in vitro

Immunomodulatory Activity on Human Macrophages by Cell-Free Supernatants to Explore the Probiotic and Postbiotic Potential of Lactiplantibacillus plantarum Strains of Plant Origin

A Systematic Review to Introduce the Most Effective Postbiotic Derived from Probiotics for Aflatoxin Detoxifications

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