“…Recently, many studies have been conducted to extract CS from Prionace glauca (Vazquez, Blanco, Fraguas, Pastrana, & Perez‐Martin, ), Chinese sturgeon cartilage (Zhao et al, ), fish bone (He et al, ), and skate cartilage (Lignot, Lahogue, & Bourseau, ). In addition, several chemical methods for synthesis of chondroitin (Kobayashi, Fujikawa, & Ohmae, ; Lopin & Jacquinet, ; Sears & Wong, ), CS and its oligosaccharides (Eller, Collot, Yin, Hahm, & Seeberger, ; Lubineau & Bonnaffé, ) have been established. Specifically, Fujikawa, Ohmae, and Kobayashi () developed an enzymatic method to produce chondroitin 4‐sulfate by enzymatic polymerization of chemically‐synthesized CSA disaccharides with hyaluronidase.…”