From plant scent defense to biopesticide discovery: Evaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes

Filho, José Guedes de Sena; Almeida, Anderson Soares de; Pinto-Zevallos, Delia M.; Barreto, Ighor Costa; Cavalcanti, Sócrates Cabral de Holanda; Nunes, Rogéria de Souza; Teodoro, Adenir Vieira; Xavier, Haroudo Sátiro; Filho, José Maria Barbosa; Guan, Leluo; Neves, Alice Cristina Medeiros das; Duringer, Jennifer M.

doi:10.1016/j.cropro.2022.106126

Cited by 13 publications

(7 citation statements)

References 95 publications

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“…Plant extracts, and especially plant EOs, have attracted the research focus in recent decades in the search for biopesticides and alternatives to synthetic chemical pesticides Due to their anti‐insect properties, plant EOs are excellent candidates for sustainable crop protection (Catani et al, 2022; De Sena Filho et al, 2022; Dubey & Mostafavi, 2023; Regnault‐Roger et al, 2012). The EO of B. spartioides had previously been evaluated by Jofré Barud et al (2014) in adult C. capitata , with a LD 50 of 11.35 and 15.34 μg/insect for females and males, respectively, after 48 h of exposure.…”

Section: Discussionmentioning

confidence: 99%

Toxicological interactions between spinosad and essential oils in the Mediterranean fruit fly, Ceratitis capitata

Cortez‐Vega,

Jofré‐Barud,

Andino

et al. 2023

J Applied Entomology

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In recent decades, the use of biopesticides for pest management has increased, especially in modern and organic agriculture. Spinosad is a biopesticide approved in many countries for its use against Ceratitis capitata. However, an increasing amount of pest resistance against spinosad had been found in different pest species. In the present study, we propose the use of a combination between essential oils (EOs) and spinosad as a way to contribute to the development of sustainable alternatives, integrating natural substances with anti‐insect properties and reducing the amount of commercial active ingredients by synergistic effects. Our primary objective was to investigate the synergistic potential of EOs and spinosad in order to enhance the insecticidal efficacy against C. capitata adults. We evaluate the toxic effect of the EOs of Baccharis spartioides (Hook), Eucalyptus cinerea (F. Muell. ex Benth) and Schinus areira (Linneo), the bioinsecticide spinosad and their combinations. We evaluated the combined toxicities of EOs from B. spartioides, E. cinerea and S. areira with spinosad and characterized the LD50 of each mixture and each substance administered topically alone on male and female individuals of C. capitata. A synergistic effect was observed for the B. spartioides–spinosad mixture in females and the S. areira–spinosad mixture in both sexes, and an antagonistic effect was found for the B. spartioides–spinosad mixture and the E. cinerea–spinosad mixture in males. Considering these results, we suggest the use of the EO from S. areira combined with spinosad as an alternative way of controlling C. capitata.

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Section: Discussionmentioning

confidence: 99%

Toxicological interactions between spinosad and essential oils in the Mediterranean fruit fly, Ceratitis capitata

Cortez‐Vega,

Jofré‐Barud,

Andino

et al. 2023

J Applied Entomology

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“…Finally, the EO of L. austroapennina was characterized by the highest abundance of linalool, terpinen-4-ol, borneol and linalool acetate. Among the monoterpenes, linalool and bornyl acetate are known for their high acaricidal activity [ 57 ]. The higher presence in the EO of L. austroapennina could explain its higher acaricidal activity than that of the other EOs tested.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition and Pharmacological Efficacy Evaluation of Calamintha nepeta, Calamintha sylvatica, Lavandula austroapennina and Mentha piperita Essential Oils for the Control of Honeybee (Apis mellifera) Varroosis

Bava,

Castagna,

Lupia

et al. 2023

Animals

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Varroa destructor is currently considered the parasite that causes the greatest damage and economic losses to honeybee farms. Its presence is often associated with that of viral and bacterial pathogens, which ultimately leads to colony collapse. Careful control of the parasitic load is therefore necessary to avoid the onset of these events. Although chemical treatments are often in easily and quickly administered formulations, in recent years, there have been increasingly frequent reports of the onset of drug resistance phenomena, which must lead to reconsidering their use. Furthermore, chemical compounds can easily accumulate in the food matrices of the hive, with possible risks for the final consumer. In such a condition, it is imperative to find alternative treatment solutions. Essential oils (EOs) prove to be promising candidates due to their good efficacy and good environmental biodegradability. In this study, the acaricidal efficacy of the EOs of Calamintha sylvatica Bromf., Calamintha nepeta Savi, Lavandula austroapennina N.G. Passal. Tundis & Upson and Mentha piperita L., extracted from botanical species belonging to the Lamiaceae family, was evaluated. The test chosen for the evaluation was residual toxicity by contact. The examined EOs were diluted in Acetone to a concentration of 2, 1 and 0.5 mg/mL. At the highest concentration, the EOs demonstrated an acaricidal activity equal to 52% for C. nepeta, 60% for C. sylvatica, 80% for L. austroapennina and 68% for M. piperita. Of the EOs tested, therefore, Lavender proves to be a good candidate for subsequent evaluations in semi-field and field studies.

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“…The site map module, which utilizes novel analytical and search methods to generate binding site information, predicted the active site of the targeted protein (CID: 107568). During the initial search step of site map prediction, grid points were characterized using the method developed by de Sena Filho et al (2023) . The protein has multiple target binding sites on its surface that can bind the ligand to the receptor.…”

Section: Methodsmentioning

confidence: 99%

Biocontrol effects of chemical molecules derived from Beauveria bassiana against larvae of Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

Vivekanandhan,

Swathy,

Alahmadi

et al. 2024

Front. Microbiol.

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In this study, we conducted tests on the isolation, identification, characterization, and extraction of chemical molecules from Beauveria bassiana against Tuta absoluta larvae. The enzyme responses of T. absoluta to the crude extract were examined 24 h after treatment, and the number of dead larvae was calculated 24 and 48 h after treatment. Molecular docking studies were conducted to assess the interaction of important molecules with the acetylcholinesterase enzyme. The larvicidal activity of crude chemicals from fungi was high 24 h after treatment, with LC50 and LC90 values of 25.937 and 33.559 μg/mL, respectively. For a period of 48 h, the LC50 and LC90 values were 52.254 and 60.450 μg/mL, respectively. The levels of acetylcholinesterase, α-carboxylesterase, and β-carboxylesterase enzymes were lower in the treatment group after 24 h compared to the control group. The GC-MS test revealed that the crude extract consisted mainly of 9,10-octadecadienoic acid, which was the primary compound. Docking results indicated that 9,10-octadecadienoic acid showed a strong interaction with acetylcholinesterase (AChE). Our findings suggest that the chemical molecule 9,10-octadecadienoic acid derived from the entomopathogenic fungus B. bassiana is more toxic to T. absoluta larvae. We plan to conduct studies to test its effectiveness in semi-field conditions and to evaluate its stability in field conditions. We believe that this 9,10-octadecadienoic acid molecule could be used to control T. absoluta larvae in the near future without causing environmental pollution.

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From plant scent defense to biopesticide discovery: Evaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes

Cited by 13 publications

References 95 publications

Toxicological interactions between spinosad and essential oils in the Mediterranean fruit fly, Ceratitis capitata

Toxicological interactions between spinosad and essential oils in the Mediterranean fruit fly, Ceratitis capitata

Phytochemical Composition and Pharmacological Efficacy Evaluation of Calamintha nepeta, Calamintha sylvatica, Lavandula austroapennina and Mentha piperita Essential Oils for the Control of Honeybee (Apis mellifera) Varroosis

Biocontrol effects of chemical molecules derived from Beauveria bassiana against larvae of Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

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