From Parametric Representation to Dynamical System: Shifting Views of the Motor Cortex in Motor Control

Wang, Tianwei; Chen, Yun; Cui, He

doi:10.1007/s12264-022-00832-x

Cited by 21 publications

(19 citation statements)

References 129 publications

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“…This would be an important step to understand whether and how different dynamic signals (e.g. acceleration, velocity) in the vestibular system may function in different contexts, just like in the motor system [134]. Finally, more and precise causal manipulation experiments need to be conducted to search for areas showing effects on behaviour under both sensory stimuli conditions.…”

Section: Looking Aheadmentioning

confidence: 99%

Visuo-vestibular heading perception: a model system to study multi-sensory decision making

Zeng,

Zhang,

2023

Phil. Trans. R. Soc. B

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Integrating noisy signals across time as well as sensory modalities, a process named multi-sensory decision making (MSDM), is an essential strategy for making more accurate and sensitive decisions in complex environments. Although this field is just emerging, recent extraordinary works from different perspectives, including computational theory, psychophysical behaviour and neurophysiology, begin to shed new light onto MSDM. In the current review, we focus on MSDM by using a model system of visuo-vestibular heading. Combining well-controlled behavioural paradigms on virtual-reality systems, single-unit recordings, causal manipulations and computational theory based on spiking activity, recent progress reveals that vestibular signals contain complex temporal dynamics in many brain regions, including unisensory, multi-sensory and sensory-motor association areas. This challenges the brain for cue integration across time and sensory modality such as optic flow which mainly contains a motion velocity signal. In addition, new evidence from the higher-level decision-related areas, mostly in the posterior and frontal/prefrontal regions, helps revise our conventional thought on how signals from different sensory modalities may be processed, converged, and moment-by-moment accumulated through neural circuits for forming a unified, optimal perceptual decision. This article is part of the theme issue ‘Decision and control processes in multisensory perception’.

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Section: Looking Aheadmentioning

confidence: 99%

Visuo-vestibular heading perception: a model system to study multi-sensory decision making

Zeng,

Zhang,

2023

Phil. Trans. R. Soc. B

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“…After pre-processing, the data was spike- Neurons in the motor cortex have been found to encode various kinetic and kinematic parameters. In particular, the dorsal premotor cortex (PMd) has long been thought to be involved in the preparation and execution of hand movements 15 . In the center-out reaching task studeies, cortical motor neurons have shown cosine tuning for the reach direction 16,17 .…”

Section: Neurophysiological Experiments and Recording Performancementioning

confidence: 99%

Flexible multi-channel electrodes for acute recording in the non-human primates

Wang

Zheng

et al. 2023

Preprint

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Flexible electrodes have demonstrated good biocompatibility compared to rigid electrodes in relieving encapsulation and long-term recording. The structural and functional properties of the brain in non-human primates are closer to those of humans than in rodents. However, the application of flexible electrodes on non-human primates has been rarely reported. One of the challenges is the long experimental iteration of the electrodes, limited by implanting period, both pre- and post-surgery. In the present study, a flexible multi-channel electrode array for non-human primates was developed and implemented to the extracellular recording in behaving monkeys. To decrease possible risks, a guide-tube-compatible implantation solution was designed to implant electrodes into the cortex without durotomy. Furthermore, packaging and acute recording of multi-channel flexible electrodes for primates were tested ex vivo and in vivo. The results showed that the flexible electrodes and implantation method used in this study meet the needs of extracellular recording in non-human primates. Task-related neuronal activities were recorded with a high signal-to-noise ratio, providing a minimally invasive and clinically viable approach for extracellular recording.

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“…The human brain, a complex dynamical system, exists in a limited number of equilibrium states, maintained by processes distributed across various neuronal networks [1]. A significant perturbation results in a phase shift in equilibirium, with associated changes across the organizational hierarchy, not limited to the perturbed region/ process.…”

Section: On the Importance Of Not Comparing Apples With Pearsmentioning

confidence: 99%

On the importance of not comparing apples with pears

Kuppuswamy

2022

Euro J of Neurology

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From Parametric Representation to Dynamical System: Shifting Views of the Motor Cortex in Motor Control

Cited by 21 publications

References 129 publications

Visuo-vestibular heading perception: a model system to study multi-sensory decision making

Visuo-vestibular heading perception: a model system to study multi-sensory decision making

Flexible multi-channel electrodes for acute recording in the non-human primates

On the importance of not comparing apples with pears

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