From neurology to oncology: what have in common autism and cancer? the role of oncogenes, immune system and microbiota

Ruggiero, Marco; Pacini, Stefania

doi:10.15406/jnsk.2018.08.00303

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Autism is a complex disorder that involves primarily the development of the brain but is also quite often associated with abnormalities of immune responses and gut function as well as with alterations of microbiota composition. We recently postulated that autism and cancer share a number of similarities at the level of cellular and molecular signal transduction, the involvement of the immune system and of the microbiota [1]. In our opinion, it is not surprising that immunotherapeutic approaches originally developed for cancer may find application in the field of autism.…”

Section: Introductionmentioning

confidence: 99%

Clinical Experience of Integrative Autism treatment with a Novel type of Immunotherapy

Antonucci¹,

Pacini²,

Ruggiero³

2019

Madridge J Vaccines

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In this study, we report the results associated with a novel type of immunotherapy based on a supplement containing low-molecular-weight chondroitin sulfate, phosphatidylcholine, and vitamin D 3 . In October 2018, the Biomedical Centre for Autism Research and Treatment of Bari, Italy, started using this approach on autistic subjects. By January 2019, several scores of patients have been treated; here, we describe the cases of three autistic patients for whom the treatment was remarkably effective. In order to obtain the most objective and complete evaluation of results, we used the Autism Treatment Evaluation Scale (ATEC), a diagnostic assessment tool that has been demonstrated effective in evaluating interventional effects in autism. Our observations indicate that some of the most representative symptoms of autism were completely normalized after eight weeks of treatment and other showed a trend toward normalization. No adverse effects were reported. Based on the cases described in this report and on our ongoing research, we are convinced that this type of supplementbased immunotherapy can be beneficial to autistic patients and represents a new and promising treatment. We expect that the described approach will play a central role in future treatments for autism, both alone and in combination with other therapies such as behavioral therapies, nutritional interventions or manual lymphatic massage.

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Section: Introductionmentioning

confidence: 99%

Clinical Experience of Integrative Autism treatment with a Novel type of Immunotherapy

Antonucci¹,

Pacini²,

Ruggiero³

2019

Madridge J Vaccines

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“…As odd as it may appear at first glance, the complexity of autism with its interconnections between different etiological agents is similar to that of cancer and the two diseases share more similarities than differences (for rev. on this topic, see Ruggiero and Pacini [2]). If etiology of autism is yet to be fully understood, its pathogenesis appears to be clearer also thanks to our previous work with the late Dr. Bradstreet.…”

Section: Introductionmentioning

confidence: 99%

Manual Lymphatic Drainage in Autism Treatment

Antonucci¹,

Pacini²,

Ruggiero³

2018

Madridge J Immunol

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In this editorial we propose an approach for improving brain lymphatic flow in autism through lymphatic drainage massage that is a strategy successfully utilized in a variety of neurological conditions where lymph coming from the brain finds obstacles at the level of deep cervical nodes. We estimate that manual lymphatic massage at the level of deep cervical nodes improves brain lymphatic drainage possibly resulting in decrease of neuroinflammation that is a hallmark of autism. In addition to stimulating lymphatic drainage, we theorize that such an approach may work also as vagus nerve stimulation with the additional benefit of targeting the larynx in a manner similar to that outlined for laryngeal manual therapy. This therapy is utilized for the treatment of dysphonia, and its effects on speech, a function that is typically altered in autism, may contribute to the overall improvement of symptoms. We propose that this type of inexpensive, safe and accessible approach can be beneficial to autistic subjects and constitute a new and promising treatment. We are convinced that the described approach will play a pivotal role in future options for autism treatment, possibly in combination with other therapeutic approaches such as behavioral therapies or nutritional supplementation.

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Fermentation of hemp seed proteins leads to formation of peptides that share sequence similarity with human vitamin D-binding protein

Ruggiero¹,

Pacini²

2020

Med Res Innov

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From neurology to oncology: what have in common autism and cancer? the role of oncogenes, immune system and microbiota

Cited by 3 publications

References 66 publications

Clinical Experience of Integrative Autism treatment with a Novel type of Immunotherapy

Clinical Experience of Integrative Autism treatment with a Novel type of Immunotherapy

Manual Lymphatic Drainage in Autism Treatment

Fermentation of hemp seed proteins leads to formation of peptides that share sequence similarity with human vitamin D-binding protein

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