From main-chain conjugated polymer photosensitizer to hyperbranched polymer photosensitizer: expansion of the polymerization-enhanced photosensitization effect for photodynamic therapy

Cheng, Jingxi; Zhou, Yuping; Xu, Shidang; Xie, Yujun; Mao, Duo; Wu, Wenbo; Li, Zhen

doi:10.1039/d2tb00679k

Cited by 14 publications

(16 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further investigate the ROS production processes, hydroxyphenyl fluorescein (HPF) and 1 O 2 sensor green (SOSG) were used to measure the types of ROS, which suggested the generation of both • OH and 1 O 2 (Figures S10 and S11). , These revealed that MDNPs were able to function as efficient PDT agents with both type I and type II processes thanks to the efficient ISC process.…”

Section: Resultsmentioning

confidence: 94%

See 1 more Smart Citation

Cancer-Cell-Biomimetic Carbazole-Based AIE Nanoplatform for Targeted Phototheranostics of Lung Cancer

Shen

Kang

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Lung cancer is one of the most diagnosed cancers and is the leading cause of cancer death. Photodynamic therapy (PDT) has been considered as a promising strategy due to its strong efficacy and negligible side effects. The development of potent PDT agents with an excellent tumor targeting capability is highly desirable but still not satisfied. In this work, we report a highly efficacious organic nanoplatform based on an aggregation-induced emission luminogen (AIEgen) and biomimetic modification for precise phototheranostics of lung cancer. An AIEgen with strong light absorption ability and bright deep red/near-infrared emission is designed and synthesized that possesses both type I and type II PDT processes. The AIEgen is encapsulated into nanoparticles (NPs) and further camouflaged with a Lewis lung carcinoma cell membrane to build a biomimetic nanoplatform. Both in vitro and in vivo experiments indicate that the cancer-cell-biomimetic NPs could significantly increase the tumor cell targeting ability and sensitively delineate the tumor site. Moreover, the cell-membrane-camouflaged NPs also show excellent antitumor efficacy in lung-cancer-bearing mice. This work demonstrates that the integration of highly efficient AIEgen and biomimetic cell membranes is able to boost the phototheranostic efficacy, representing a promising strategy for precise cancer diagnosis and treatment.

show abstract

Section: Resultsmentioning

confidence: 94%

“…2′,7′-Dichlor- S11). 58,59 These revealed that MDNPs were able to function as efficient PDT agents with both type I and type II processes thanks to the efficient ISC process.…”

Section: Resultsmentioning

confidence: 99%

Cancer-Cell-Biomimetic Carbazole-Based AIE Nanoplatform for Targeted Phototheranostics of Lung Cancer

Shen

Kang

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Recently, to further expand the polymerization-enhanced photosensitization effect, our group prepared three different types of AIE CPs: the main chain type, P13, side chain type, P14, and hyperbranched type, P15, with the same donor and acceptor (Figure 7D). [55] Owing to the reversible redox capacity of the AQ moiety, all three polymers produced not only 1 O 2 but also superoxide radicals (O 2…”

Section: Polymerization-enhanced Photosensitization Effectmentioning

confidence: 99%

“…Recently, to further expand the polymerization‐enhanced photosensitization effect, our group prepared three different types of AIE CPs: the main chain type, P13 , side chain type, P14 , and hyperbranched type, P15 , with the same donor and acceptor (Figure 7D). [ 55 ] Owing to the reversible redox capacity of the AQ moiety, all three polymers produced not only 1 O 2 but also superoxide radicals (O 2 •− ) and hydroxyl radicals (•OH) by Type‐I photosensitization upon excitation. In comparison with the traditional main‐chain and side‐chain CPs, the special 3D dendritic structures of P15 could improve the contact with oxygen, leading to higher ROS‐generation efficiencies.…”

Section: Polymerization‐enhanced Photosensitization Effectmentioning

confidence: 99%

Conjugated‐Polymer‐Based Photodynamic Therapy

2022

Advanced Therapeutics

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a promising method for cancer treatment owing to its high spatiotemporal precision and minimally invasive properties. The efficiency of reactive oxygen species (ROS) production by photosensitizers (PSs) directly affects PDT efficacy. Conjugated polymers (CPs) exhibit excellent light‐harvesting capabilities and effective intra‐ and intermolecular energy transfer between CPs and traditional PSs by the “molecular wire effect,” leading to a significant improvement in ROS generation efficiency when PSs are carefully paired with suitable CPs as energy donors. The recently proposed “polymerization‐enhanced photosensitization effect” further reveals that donor–acceptor type CPs can directly function as high‐performance PSs. Recently, two‐photon excitation and chemiluminescence excitation technologies are employed to enhance the penetration depth, a common challenge in phototherapy of CP‐based PDT systems. Furthermore, if precisely designed, CPs can endow the system with useful functions such as photothermal effects and drug‐delivery capacity, which can lead to a synergistic therapy with PDT. Here, recent advances are summarized in CP‐based PDT, including its underlying phenomena, mechanisms, and applications. Strategies for improving PDT performance are the focus of the discussions. In the conclusion, challenges and opportunities are discussed by considering further perspectives.

show abstract

“…Third, polymers as active bio‐targeting groups. Materials with pronounced triplet activity after photoexcitation are routinely assessed as antimicrobial agents for photodynamic therapy [4, 44–48] . For pathogenic bacterial, for example, the more localized negative charge can make them a target for positively charged polymers (e.g., commercially used polyhexamethylene guanidine).…”

Section: Introductionmentioning

confidence: 99%

Functional Roles of Polymers in Room‐Temperature Phosphorescent Materials: Modulation of Intersystem Crossing, Air Sensitivity and Biological Activity

Huang

et al. 2023

Angew Chem Int Ed

View full text Add to dashboard Cite

Organic room-temperature phosphorescent (RTP) materials routinely incorporate polymeric components, which usually act as non-functional or "inert" media to protect excited-state phosphors from thermal and collisional quenching, but are lesser explored for other influences. Here, we report some exemplary "active roles" of polymer matrices played in organic RTP materials, including: 1) color modulation of total delayed emissions via balancing the population ratio between thermally-activated delayed fluorescence (TADF) and RTP due to dielectric-dependent intersystem crossing; 2) altered air sensitivity of RTP materials by generating various surface morphologies such as nano-sized granules; 3) enhanced bacterial elimination for enhanced electrostatic interactions with negatively charged bio-membranes. These active roles demonstrated that the vast library of polymeric structures and functionalities can be married to organic phosphors to broaden new application horizons for RTP materials.

show abstract

From main-chain conjugated polymer photosensitizer to hyperbranched polymer photosensitizer: expansion of the polymerization-enhanced photosensitization effect for photodynamic therapy

Abstract: Three conjugated polymers with the same donor-acceptor structure but totally different architectures are design to show both Type-I and Type-II photosensitization abilities simultaneously, among which the hyperbranched polymer shows the...

Cited by 14 publications

References 52 publications

Cancer-Cell-Biomimetic Carbazole-Based AIE Nanoplatform for Targeted Phototheranostics of Lung Cancer

Cancer-Cell-Biomimetic Carbazole-Based AIE Nanoplatform for Targeted Phototheranostics of Lung Cancer

Conjugated‐Polymer‐Based Photodynamic Therapy

Functional Roles of Polymers in Room‐Temperature Phosphorescent Materials: Modulation of Intersystem Crossing, Air Sensitivity and Biological Activity

Contact Info

Product

Resources

About