Cancer-Cell-Biomimetic Carbazole-Based AIE Nanoplatform for Targeted Phototheranostics of Lung Cancer

Abstract

Lung cancer is one of the most diagnosed cancers and is the leading cause of cancer death. Photodynamic therapy (PDT) has been considered as a promising strategy due to its strong efficacy and negligible side effects. The development of potent PDT agents with an excellent tumor targeting capability is highly desirable but still not satisfied. In this work, we report a highly efficacious organic nanoplatform based on an aggregation-induced emission luminogen (AIEgen) and biomimetic modification for precise phototheranostics of lung cancer. An AIEgen with strong light absorption ability and bright deep red/near-infrared emission is designed and synthesized that possesses both type I and type II PDT processes. The AIEgen is encapsulated into nanoparticles (NPs) and further camouflaged with a Lewis lung carcinoma cell membrane to build a biomimetic nanoplatform. Both in vitro and in vivo experiments indicate that the cancer-cell-biomimetic NPs could significantly increase the tumor cell targeting ability and sensitively delineate the tumor site. Moreover, the cell-membrane-camouflaged NPs also show excellent antitumor efficacy in lung-cancer-bearing mice. This work demonstrates that the integration of highly efficient AIEgen and biomimetic cell membranes is able to boost the phototheranostic efficacy, representing a promising strategy for precise cancer diagnosis and treatment.

Nanotechnology Meets Stem Cell Therapy for Treating Glioblastomas: A Review

“…Organic nanoparticles (ONPs) including liposome/vesicles, dendrimers, polymeric NPs (PNPs), fluorescent organic nanoparticles (FONPs) have been extensively researched for many years, exploiting as a wide array of drug delivery vector (Table ). − Decades of research have led to the development of multiple generations of ONPs. In the realm of cancer therapy, ONPs serve as an excellent platform for in vivo delivery of numerous hydrophobic and hydrophilic antitumor drugs.…”

Cancer Cell Membrane-Coated Nanoparticles for Treatment of Oral Tongue Squamous Cell Carcinoma by Combining Photothermal/Photodynamic Therapy and Autophagy Inhibition

“…However, the drawbacks of this hydrophilicity photosensitizer such as instability in blood circulation, low cellular uptake efffciency, and weak tumor-targeting capability greatly limit its application in anticancer strategies. , Currently, the biomimetic nanoparticle modification strategy has attracted more and more attention. Various extracted types of biomembranes coated on nanocarriers through special technology can endow nanoparticles with relative biological characteristics, thus exhibiting excellent anticancer efficacy. , Homologous tumor cells can exhibit self-recognition and agglomeration homing effects due to their similar proteins such as adhesion molecules expressed on the surface of cell membranes. − Therefore, when encapsulated within the OTSCC cell membrane vesicles, the nanoparticles will be forecasted to achieve specific recognition and efficient cellular uptake by homologous OTSCC, thus hoping to overcome the limitations of ICG mentioned above.…”

Fabrication of photoluminescent nanoparticles from carbazole-derived chalcones: a study of optical properties, cell biomarking, and metabolism

“…34,35 Recently, nanoparticles of compounds derived from carbazole have been manufactured, which have allowed for improving selectivity and biocompatibility with the biological system. 36,37…”

“…34,35 Recently, nanoparticles of compounds derived from carbazole have been manufactured, which have allowed for improving selectivity and biocompatibility with the biological system. 36,37 The use of organic fluorophores for photodynamic therapy involves the evaluation of the optical and toxicological properties. For this reason, manufacturing methods of luminescent organic nanoparticles coated with a biocompatible material have been reported using techniques such as microemulsion and reprecipitation, where the optical properties have been preserved, and biocompatibility has improved.…”