From Heart Failure to Highly Unsaturated Fatty Acid Deficiency and Vice Versa: Bidirectional Heart and Liver Interactions

Alter, Peter; Glück, Tobias; Figiel, Jens; Koczulla, A. Rembert; Vogelmeier, Claus; Rupp, Heinz

doi:10.1016/j.cjca.2015.05.019

Cited by 12 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The co-existence of bidirectional communication was also confirmed in patients with heart failure [127]. Impaired left ventricular function was associated with a decrease of endogenous hepatic unsaturated fatty acids circulatory levels.…”

Section: The Heart-liver Axismentioning

confidence: 69%

“…Impaired left ventricular function was associated with a decrease of endogenous hepatic unsaturated fatty acids circulatory levels. It was hypothesized that an increased left ventricular wall stress and pulmonary pressure can be transmitted to the liver veins and cause hepatic congestion and consequently may alter the fatty acid profile in the liver [127]. On the other hand, reduced levels of unsaturated fatty acids were correlated with adverse cardiac consequences, probably by interfering with proinflammatory processes such as nuclear factor κB (NF-κB) activation and TNF-α release [127,128].…”

Section: The Heart-liver Axismentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Heart Disease and Liver Disease: A Two-Way Street

Hadi

Vincenzo

Rossato

2020

Cells

103

125

View full text Add to dashboard Cite

In clinical practice, combined heart and liver dysfunctions coexist in the setting of the main heart and liver diseases because of complex cardiohepatic interactions. It is becoming increasingly crucial to identify these interactions between heart and liver in order to ensure an effective management of patients with heart or liver disease to provide an improvement in overall prognosis and therapy. In this review, we aim to summarize the cross-talk between heart and liver in the setting of the main pathologic conditions affecting these organs. Accordingly, we present the clinical manifestation, biochemical profiles, and histological findings of cardiogenic ischemic hepatitis and congestive hepatopathy due to acute and chronic heart failure, respectively. In addition, we discuss the main features of cardiac dysfunction in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and those following liver transplantation.

show abstract

Section: The Heart-liver Axismentioning

confidence: 69%

Section: The Heart-liver Axismentioning

confidence: 99%

Relationship between Heart Disease and Liver Disease: A Two-Way Street

Hadi

Vincenzo

Rossato

2020

Cells

103

125

View full text Add to dashboard Cite

show abstract

“…Therefore, an intraventricular pressure of 16 mm Hg at enddiastole and 130 mm Hg at endsystole was assumed for approximation as described previously [9,11,19]. The effective resultant pressure gradient transmitting distending forces on the myocardium is influenced by intraventricular luminal pressure and the surrounding pleural and thoracic pressure ( Fig.…”

Section: Left Ventricular Volume Myocardial Mass and Wall Stressmentioning

confidence: 99%

Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure

Alter

Sand

Nell

et al. 2015

Respiratory Medicine

Self Cite

View full text Add to dashboard Cite

The severity of airflow limitation in COPD was correlated with increased LV wall stress. It is suggested that respiration in pulmonary obstruction is associated with an increased negative intrathoracic pressure when compared with normal lung function, which is transmitted to the heart and increases the transmural pressure gradient and thereby distending forces on the heart. Increased ventricular wall stress is known to be associated with a broad variety of unfavourable consequences, which should be taken into account to contribute to a worse prognosis in COPD.

show abstract

“…Previous studies indicated that reduced serum concentrations of omega-3 and omega-6 HUFA were associated with the progression of HF (26–28). Alter et al (29) suggested that increased ventricular wall stress and a reduced LVEF were associated with decreased docosahexaenoic acid, a HUFA. Furthermore, a clinical study demonstrated that dietary supplementation with the HUFA eicosapentaenoic and docosahexaenoic acids may prevent sudden cardiac death, acute coronary syndrome and HF (30).…”

Section: Discussionmentioning

confidence: 99%

Identification of time‑series differentially expressed genes and pathways associated with heart failure post‑myocardial infarction using integrated bioinformatics analysis

Jiang

2019

Mol Med Report

View full text Add to dashboard Cite

Heart failure (HF) secondary to acute myocardial infarction (AMI) is a public health concern. The current study aimed to investigate differentially expressed genes (DEGs) and their possible function in HF post-myocardial infarction. The GSE59867 dataset included microarray data from peripheral blood samples obtained from HF and non-HF patients following AMI at 4 time points (admission, discharge, and 1 and 6 months post-AMI). Time-series DEGs were analyzed using R Bioconductor. Functional enrichment analysis was performed, followed by analysis of protein-protein interactions (PPIs). A total of 108 DEGs on admission, 32 DEGs on discharge, 41 DEGs at 1 month post-AMI and 19 DEGs at 6 months post-AMI were identified. Among these DEGs, 4 genes were downregulated at all the 4 time points. These included fatty acid desaturase 2, leucine rich repeat neuronal protein 3, G-protein coupled receptor 15 and adenylate kinase 5. Functional enrichment analysis revealed that these DEGs were mainly enriched in ‘inflammatory response’, ‘immune response’, ‘toll-like receptor signaling pathway’ and ‘NF-κβ signaling pathway’. Furthermore, PPI network analysis revealed that C-X-C motif chemokine ligand 8 and interleukin 1β were hub genes. The current study identified candidate DEGs and pathways that may serve important roles in the development of HF following AMI. The results obtained in the current study may guide the development of novel therapeutic agents for HF following AMI.

show abstract

From Heart Failure to Highly Unsaturated Fatty Acid Deficiency and Vice Versa: Bidirectional Heart and Liver Interactions

Cited by 12 publications

References 50 publications

Relationship between Heart Disease and Liver Disease: A Two-Way Street

Relationship between Heart Disease and Liver Disease: A Two-Way Street

Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure

Identification of time‑series differentially expressed genes and pathways associated with heart failure post‑myocardial infarction using integrated bioinformatics analysis

Contact Info

Product

Resources

About