Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure

Abstract

The severity of airflow limitation in COPD was correlated with increased LV wall stress. It is suggested that respiration in pulmonary obstruction is associated with an increased negative intrathoracic pressure when compared with normal lung function, which is transmitted to the heart and increases the transmural pressure gradient and thereby distending forces on the heart. Increased ventricular wall stress is known to be associated with a broad variety of unfavourable consequences, which should be taken into account to contribute to a worse prognosis in COPD.

Safety of tiotropium/olodaterol in chronic obstructive pulmonary disease: pooled analysis of three large, 52-week, randomized clinical trials

“…The lower rate of some cardiovascular AEs may be related to the reduction in hyperinflation that is seen with tiotropium/olodaterol compared with tiotropium [10]; studies show that severity of airflow limitation in COPD is associated with increased left ventricular wall stress [13], and that treatment with a LAMA/LABA or LABA/ICS in patients with COPD has positive effects on cardiac function [14,15].…”

Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study

“…A variety of cardiopulmonary interactions have been described in COPD [40] . Besides common shared risk factors, pathophysiological mechanisms linking heart size, morphology, and function to COPD should be taken into account.…”

Pulmonary function predicts mortality and hospitalizations in outpatients with heart failure and preserved ejection fraction

“…Since aging and smoking are shared risk factors for both cardiovascular and respiratory diseases, it is not surprising that many elderly subjects suffer both types of diseases [20][21][22]. Airflow limitation and/or hypoxemia can be due to several respiratory (COPD, asthma) and/or cardiac diseases (pulmonary edema) which may be often not easy to disentangle (or coincident).…”