From H1N1 to COVID-19: What we have seen in children with hemoglobinopathies

Oliveira, Claudia de Melo; Soares, Victor Jablonski; Rechenmacher, Ciliana; Daudt, Liane Esteves; Michalowski, Mariana Bohns

doi:10.1016/j.clinsp.2021.100004

Cited by 1 publication

(2 citation statements)

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“…It is interesting to notice that, at the beginning of this trial, a much higher number of patients with SCD was expected to require hospitalization for SARS-CoV-2 infection. This assumption was based on the previous experience during the influenza H1N1 pandemic [ 13 ]. In a study with 40 children with SCD who were diagnosed with H1N1, 50% of them were admitted to the hospital and 25% developed acute chest syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective cohort conducted at Johns Hopkins Hospital analyzed cases of influenza A, B, and H1N1 in children and young adults with SCD and found that these patients needed intensive care more often and received more blood transfusions and antiviral treatments, in addition to developing acute chest syndrome and having episodes of intense pain [ 15 ]. Studies have shown that the predisposition to organ complications and hypoxia is greater in patients with SCD affected by respiratory viruses [ 5 , 13 – 15 ]. The pathophysiology of SCD could play the key role in this fact.…”

Section: Discussionmentioning

confidence: 99%

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The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry

et al. 2023

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Objective To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19. Method A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded include clinical symptoms, diagnostic methods, therapeutic measures, and treatment sites. The clinical repercussions of the infection on the initial treatment and the overall prognosis were also evaluated. Results Twenty-five unvaccinated children, aged 4 to 17 years, with SCD and a positive SARS-CoV-2 RT-PCR result participated in this study. Patients were classified as SCD types SS (n = 20, 80%) and SC (n = 5, 20%). Clinical characteristics and evolution were similar in both groups (p>0.05), except for the fetal hemoglobin value which was higher among the SC patients (p = 0.025). The most frequent symptoms were hyperthermia (72%) and cough (40%). Three children were admitted to the intensive care unit, all of whom were overweight/obese (p = 0.078). No deaths were observed. Conclusions Although SCD leads to specific complications, the results found in this sample suggest that COVID-19 does not seem to carry an increased mortality risk in pediatric patients with this disease.

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Section: Discussionmentioning

confidence: 99%