From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes: the global registry of acute coronary events (GRACE)

Fox, Keith; Goodman, Shaun G.; Anderson, Fred

doi:10.1016/j.accreview.2003.10.065

Cited by 57 publications

(83 citation statements)

References 10 publications

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“…Brazil has participated in several national and international multicenter studies/registries [4][5][6] on unstable myocardial ischemic syndromes, which has allowed surveys on the approaches used in the participating centers; however, these centers do not necessarily reflect the country's reality as a whole, as they are chosen taking into account specific features such as complexity, presence of certain procedures, previous experience in research, location etc. Frequently, data are obtained from participating centers in international multicenter studies, thus following the criteria for patient and center selection in accordance with the requirements of the study itself.…”

Section: Introductionmentioning

confidence: 99%

Utilização de terapêuticas comprovadamente úteis no tratamento da coronariopatia aguda: comparação entre diferentes regiões brasileiras. Análise do Registro Brasileiro de Síndromes Coronarianas Agudas (BRACE - Brazilian Registry on Acute Coronary Syndromes)

Nicolau¹,

Franken²,

Lotufo³

et al. 2012

Arq. Bras. Cardiol.

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Section: Introductionmentioning

confidence: 99%

Utilização de terapêuticas comprovadamente úteis no tratamento da coronariopatia aguda: comparação entre diferentes regiões brasileiras. Análise do Registro Brasileiro de Síndromes Coronarianas Agudas (BRACE - Brazilian Registry on Acute Coronary Syndromes)

Nicolau¹,

Franken²,

Lotufo³

et al. 2012

Arq. Bras. Cardiol.

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“…In fact, the use of the generality of the drugs recommended in the context of ACS was far superior compared to international multicenter studies (13,30).…”

Section: Discussionmentioning

confidence: 99%

Impact of previous insulin therapy on the prognosis of diabetic patients with acute coronary syndromes

António

Soares²,

Lourenco

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To determine whether previous insulin treatment independently influences subsequent outcomes in diabetic patients with ACS (acute coronary syndromes). Subjects and methods: 375 diabetic patients with ACS, divided in 2 groups: Group A (n = 69) -previous insulin and Group B (n = 306) -without previous insulin. Predictors of 1-year mortality and major adverse cardiac events (MACE) were analyzed by Cox regression analysis. Results: Group A had more previous stroke (17.4% vs. 9.2%, p = 0.047) and peripheral artery disease (13.0% vs. 3.6%, p = 0.005). They had significantly higher admission glycemia and lower LDL cholesterol. There were no significant differences in the type of ACS, in 1-year mortality (18.2% vs. 10.4%, p = 0.103) or MACE (32.1% vs. 23.0%, p = 0.146) between groups. In multivariate analysis, insulin treatment was neither an independent predictor of 1-year mortality nor of MACE. Conclusion: Despite the more advanced atherosclerotic disease, diabetics under insulin had similar outcomes to those without insulin. Insulin may protect diabetics from the expected poor adverse outcome of an advanced atherosclerotic disease. Arq Bras Endocrinol Metab. 2010;54(7):612-9 Keywords Insulin; diabetes; acute coronary syndromes; outcomes RESUMO Objectivo: Avaliar se a insulinoterapia prévia influencia de forma independente o prognóstico de diabéticos após uma síndrome coronária aguda (SCA). Sujeitos e métodos: 375 doentes diabéti-cos com SCA, divididos em 2 grupos: Grupo A (n = 69) -sob insulinoterapia prévia e Grupo B (n = 306) -sem insulinoterapia prévia. Os preditores de mortalidade a um ano e de eventos cardíacos adversos maiores (MACE) foram determinados pela regressão de Cox. Resultados: Verificou-se maior proporção de acidente vascular cerebral prévio (17,4% vs. 9,2%, p = 0,047) e doença arterial periférica (13,0% vs. 3,6%, p = 0,005) no Grupo A. Esses doentes apresentaram glicemia na admissão significativamente mais elevada e LDL inferior. Não houve diferenças estatisticamente significativas no tipo de SCA, na mortalidade (18,2% vs. 10,4%, p = 0,103) e MACE (32,1% vs. 23,0%, p = 0,146) em um ano entre os 2 grupos. Na análise multivariada, a insulinoterapia prévia não foi preditor independente nem de mortalidade, nem de MACE em 1 ano. Conclusão: Apesar da doença aterosclerótica mais avançada, os diabéticos previamente insulino-tratados têm um prognóstico semelhante aos não insulino-tratados. A insulinoterapia crônica poderá proteger os diabéticos da evolução desfavorável própria da doença aterosclerótica avançada. Arq Bras Endocrinol Metab. 2010;54(7):612-9 Descritores Insulina; diabetes; síndromes coronárias agudas; prognóstico Copyright © ABE&M todos os direitos reservados. 613Arq Bras Endocrinol Metab. 2010;54/7Insulin and acute coronary syndromes

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“…была хуже, чем в развитых странах АНАЛИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ [9 -11]. Однако выход клинических рекомендаций мо-жет оказывать существенное влияние на повседневную клиническую практику [12]. Именно поэтому знания об эволюции лечения ОКС на догоспитальном этапе за последние годы необходимы для оптимизации фарма-котерапии и разработки учебно-информационных мероприятий.…”

Section: анализ фармакотерапии острого коронарного синдрома на догоспunclassified

Analysis of Pre-Hospital Treatment of Acute Coronary Syndrome

Reshetko

Magdeev

Furman

2007

Racionalʹnaâ farmakoterapiâ v kardiologii

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From guidelines to clinical practice: the impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes: the global registry of acute coronary events (GRACE)

Cited by 57 publications

References 10 publications

Utilização de terapêuticas comprovadamente úteis no tratamento da coronariopatia aguda: comparação entre diferentes regiões brasileiras. Análise do Registro Brasileiro de Síndromes Coronarianas Agudas (BRACE - Brazilian Registry on Acute Coronary Syndromes)

Utilização de terapêuticas comprovadamente úteis no tratamento da coronariopatia aguda: comparação entre diferentes regiões brasileiras. Análise do Registro Brasileiro de Síndromes Coronarianas Agudas (BRACE - Brazilian Registry on Acute Coronary Syndromes)

Impact of previous insulin therapy on the prognosis of diabetic patients with acute coronary syndromes

Analysis of Pre-Hospital Treatment of Acute Coronary Syndrome

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