This study explores both teachers’ and students’ perceptions regarding the teaching and learning of general education (GE) courses in an online environment, where activities such as pair work, group work, and discussion frequently feature. These activities typically necessitate a high level of interaction during class time. This presents an intriguing environment for studying both teachers’ and learners’ experiences due to the abrupt switch to online education in recent years. The participants included 10 Thai teachers of GE courses and 431 Thai and international undergraduates enrolled in the GE courses and taught via an online platform. Online questionnaires and interviews were used to obtain participants’ perceptions of both instructors’ and students’ experiences regarding online learning, particularly in terms of communication difficulties and potential intercultural communication difficulties. The data obtained from the online questionnaire was analyzed using descriptive statistics. The frequency count and the percentage were used for calculating and thematizing the numeric data. Interview data was transcribed, analyzed, and reported based on themes. Key quotes from the participants’ responses were collated and presented in a narrative. The findings revealed the students’ and the lecturers’ perceptions of the benefits of online teaching, challenges, and their future needs.