From a basic principle of evolution to the heart rate of mammals

Wang, Yuh‐Ying Lin; Wang, Wei‐Kung

doi:10.1113/jp270123

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…Thus, the variation of harmonics reveals variation of status of the arterial system, which has been proved a useful method in cardiovascular researches [18] . According to the observation of the previous researches, Lin Wang et al developed a PS wave model to simulate the low damped oscillation of arterial pressure wave [19] – [24] and to elaborate the meaning of the harmonic components in cardiovascular physiology [25] , [26] .…”

Section: Introductionmentioning

confidence: 99%

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Chang

Chen

Wang

2015

IEEE J. Transl. Eng. Health Med.

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This study was aimed to establish a standard protocol and to quantitatively assess the reliability of harmonic analysis of the radial pulse wave measured by a harmonic wave analyzer (TD01C system). Both intraobserver and interobserver assessments were conducted to investigate whether the values of harmonics are stable in successive measurements. An intraclass correlation coefficient (ICC) and a Bland–Altman plot were used for this purpose. For the reliability assessments of the intraobserver and the interobserver, 22 subjects (mean age 45 ± 14 years; 14 males and 8 females) were enrolled. The first eleven harmonics of the radial pulse wave presented excellent repeatability (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {ICCs}>0.9$ \end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the intraobserver assessment and high reproducibility (ICCs range from 0.83 to 0.96 and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\text {p}<0.001$ \end{document}) for the interobserver assessment. The Bland–Altman plot indicated that more than 90% of harmonic values fell within two standard deviations of the mean difference. Thus, we concluded that the harmonic analysis of the radial pulse wave using the TD01C system is a feasible and reliable method to assess a hemodynamic characteristic in clinical trial.

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Section: Introductionmentioning

confidence: 99%

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Chang

Chen

Wang

2015

IEEE J. Transl. Eng. Health Med.

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“…Contracting the heart at the fundamental frequency of the arterial system will preserve maximum energy in the ventricle‐arterial system (Wang et al ; Lin Wang et al , ) and achieve the highest efficiency of perfusion of the organs (Wang and Wang , , ). This way of working will reduce the burden on the heart and use the least power to maintain the blood supply to the body, which will manifest with the optimal harmonic amplitude and the smallest coefficient variations in these harmonics (Lin Wang et al ; Lin Wang and Wang ). However, the progression of aging atherosclerosis and cardiovascular disease will alter the perfusion status and elasticity of the macrovascular bed or microvascular bed, leading to deviations in specific frequency characteristics of the organs (Jan et al, ; Hsu et al ).…”

Section: Discussionmentioning

confidence: 99%

Risk assessment of macrovascular and microvascular events in patients with type 2 diabetes by analyzing the amplitude variation of the fourth harmonic component of radial pulse wave

Liao

Chang²,

Wang³

et al. 2019

Physiol Rep

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This investigation explored the hypothesis that whether the coefficient of variation of the fourth harmonic amplitude of the radial pulse wave (C4CV) predicts the risk of macrovascular and microvascular events in patients with type 2 diabetes mellitus (T2DM). Radial pulse wave and brachial blood pressure were measured at baseline in 2324 patients with T2DM and C4CV was calculated using the Fourier series method. Macrovascular and microvascular events during follow‐up were determined by medical records. We plotted the Kaplan–Meier curve and performed a Cox proportional hazard model and a log‐rank test to estimate the effectiveness of C4CV as a risk predictor. We divided patients into quartile groups based on C4CV (<4.3%, 4.3% to 6.8%, 6.8% to 11.4%, and >11.4%). Compared with patients with C4CV < 4.3%, patients with C4CV> 11.4% had a double incidence of macrovascular events (hazard ratio, 2.13; 95% CI, 1.70–2.67) and microvascular events (hazard ratio, 2.08; 95% CI, 1.67–2.58), and the incidence of cardiovascular death was three times (hazard ratio, 3.03; 95% CI, 1.10–8.83). The Cox regression analysis demonstrated that the risk of both macrovascular and microvascular outcomes increases with the increase in quartile level of C4CV value (P < 0.0001). These associations remained after adjustment for age, gender, smoking, systolic blood pressure, diastolic blood pressure, dyslipidemia, diabetes duration, Hba1c, and cardiovascular disease (P < 0.0001). C4CV is a novel independent predictor of cardiovascular mortality, macrovascular events, and microvascular events in patients with T2DM.

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“…To find the accumulative effect of repeated heartbeats, we do not treat the arterial pulse as a travelling wave, but instead solve the PR wave equation by the Bernoulli's oscillatory method . The solution for the distributed steady‐state oscillation of an artery was then used to define two frequency matching rules quantitatively and to analyse how aortic resonance and organ resonance can enhance the efficiency of the VA system . Animal and tube simulation experiments were performed to manifest the arterial resonance.…”

mentioning

confidence: 99%

“…To achieve power saving through optimal aortic resonance, one should maintain both a stable heartbeat and a good posture that can retain the proper longitudinal stretching and the rotational symmetry along the entire aorta. This hemodynamic model which includes the three missing concepts is realistic and can explain many physiological facts such as the similarity of mammalian anatomy; we suggest that it is essential to incorporate this model into future cardiovascular studies.…”

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confidence: 99%

Did you know how the cardiovascular system achieves its high efficiency as a compound irrigation device and why this is relevant to future cardiovascular studies

Wang

2018

Acta Physiologica

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From a basic principle of evolution to the heart rate of mammals

Cited by 7 publications

References 9 publications

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Development of a Standard Protocol for the Harmonic Analysis of Radial Pulse Wave and Assessing Its Reliability in Healthy Humans

Risk assessment of macrovascular and microvascular events in patients with type 2 diabetes by analyzing the amplitude variation of the fourth harmonic component of radial pulse wave

Did you know how the cardiovascular system achieves its high efficiency as a compound irrigation device and why this is relevant to future cardiovascular studies

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