Did you know how the cardiovascular system achieves its high efficiency as a compound irrigation device and why this is relevant to future cardiovascular studies

Wang, Yuh‐Ying Lin; Wang, Wei‐Kung

doi:10.1111/apha.13206

Cited by 4 publications

(2 citation statements)

References 8 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We propose that increasing C4CV may be a sign that the fundamental frequency of the arterial system does not match the heart rate. Contracting the heart at the fundamental frequency of the arterial system will preserve maximum energy in the ventricle‐arterial system (Wang et al ; Lin Wang et al , ) and achieve the highest efficiency of perfusion of the organs (Wang and Wang , , ). This way of working will reduce the burden on the heart and use the least power to maintain the blood supply to the body, which will manifest with the optimal harmonic amplitude and the smallest coefficient variations in these harmonics (Lin Wang et al ; Lin Wang and Wang ).…”

Section: Discussionmentioning

confidence: 99%

“…None of them directly measured the physical characteristics of the entire ventricle‐arterial system. Lin et al used a biomechanical model to explain why harmonic analysis of radial pulse waves is one of the complete methods for assessing the physical properties of the ventricular‐arterial system, and why these harmonic indicators of arterial pulse can reflect the function of the heart and organs (Lin Wang et al ; Wang and Wang ; Lin Wang ). Our previous study found that traditional cardiovascular risk factors have limitations in identifying patients with T2DM who is at high risk of heart disease, especially in those without angina symptoms or history of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk assessment of macrovascular and microvascular events in patients with type 2 diabetes by analyzing the amplitude variation of the fourth harmonic component of radial pulse wave

Liao

Chang²,

Wang³

et al. 2019

Physiol Rep

View full text Add to dashboard Cite

This investigation explored the hypothesis that whether the coefficient of variation of the fourth harmonic amplitude of the radial pulse wave (C4CV) predicts the risk of macrovascular and microvascular events in patients with type 2 diabetes mellitus (T2DM). Radial pulse wave and brachial blood pressure were measured at baseline in 2324 patients with T2DM and C4CV was calculated using the Fourier series method. Macrovascular and microvascular events during follow‐up were determined by medical records. We plotted the Kaplan–Meier curve and performed a Cox proportional hazard model and a log‐rank test to estimate the effectiveness of C4CV as a risk predictor. We divided patients into quartile groups based on C4CV (<4.3%, 4.3% to 6.8%, 6.8% to 11.4%, and >11.4%). Compared with patients with C4CV < 4.3%, patients with C4CV> 11.4% had a double incidence of macrovascular events (hazard ratio, 2.13; 95% CI, 1.70–2.67) and microvascular events (hazard ratio, 2.08; 95% CI, 1.67–2.58), and the incidence of cardiovascular death was three times (hazard ratio, 3.03; 95% CI, 1.10–8.83). The Cox regression analysis demonstrated that the risk of both macrovascular and microvascular outcomes increases with the increase in quartile level of C4CV value (P < 0.0001). These associations remained after adjustment for age, gender, smoking, systolic blood pressure, diastolic blood pressure, dyslipidemia, diabetes duration, Hba1c, and cardiovascular disease (P < 0.0001). C4CV is a novel independent predictor of cardiovascular mortality, macrovascular events, and microvascular events in patients with T2DM.

show abstract