Friedelin derivatives from Phyllanthus muellerianus

Adesida, G.A.; Girgis, Pamela; Taylor, David A.

doi:10.1016/0031-9422(72)80070-0

Cited by 14 publications

(2 citation statements)

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“…Fresh leaves and decoction are used to treat constipation, bronchitis, and urethral discharges ( Chopra et al, 1986 ; Siram et al, 2004 ). The bark of P. muellerianus has been shown to contain 22β-hydroxyfriedel-1-ene, 1β, 22β-hydroxyfriedel-1-ene ( Adesida et al, 1972 ). In addition, geraniin, furosin, corilagin, isoquercitrin, astragalin, rutin, phaselic acid, gallic acid, methylgallate, caffeic acid, chlorogenic acid, 3,5-o-dicaffeoylquinic acid have been isolated from the leaves and aerial parts of P. muellerianus ( Agyare et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus

et al. 2018

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Phyllanthus muellerianus (Family Euphorbiaceae) is a shrub, which is widely distributed in West Africa and employed traditionally as a wound-healing agent especially in Ghana. The aim of the study was to determine the in vivo wound-healing activity of aqueous aerial part extract of P. muellerianus (PLE) and its major isolate, geraniin. Excision and incision wound models were used to determine the wound-healing activity. Wounds were treated with PLE (0.25, 0.5, and 1% w/w) and geraniin (0.1, 0.2, and 0.4% w/w) aqueous creams. PLE and geraniin significantly (p < 0.001) increased wound contraction rate and hydroxyproline production compared to untreated wounds. Histological studies of wound tissues showed high levels of fibroblasts and increased collagen content and cross-linking in PLE and geraniin-treated wound tissues. Immuno-histochemical investigations revealed high levels of TGF-β1 in PLE and geraniin-treated wound tissues compared to the untreated wound tissues. Tensile strength of incised wounds was significantly (p < 0.05) high in PLE and geraniin-treated wounds. PLE (0.1–100 μg/mL) significantly (p < 0.001) reduce LDH release from HaCaT-keratinocytes compared to the untreated cells. PLE and geraniin possess wound healing and cytoprotective effect.

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Section: Introductionmentioning

confidence: 99%

Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus

et al. 2018

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“…In this context, different classes of organic compounds of medicinal interest have been reported, including alkaloids (FoussardBlampin et al, 1967;Willamman and Li, 1970;Mensah et al, 1988), flavonoids (Foo and Wong, 1992), sterols and triterpenes (Adesida et al, 1972), tannins (Ueno et al, 1988). Presence and characterization of essential oil in the genus Phyllanthus were investigated only in two species: Phyllanthus emblica (Liu et al, 2009), and Phyllanthus amarus (Ogunlesi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%