Friedel–Crafts acylation of ferrocene with alkynoic acids

Synthesis of Ferrocenyl Thioketones and their Reactions with Diphenyldiazomethane

“…Therefore, we elaborated a new method based on the acylation via the in situ generated mixed anhydrides. 10 In the case of 1a, ferrocenyl carboxylic acid was mixed with an equimolar amount of trifluoroacetic anhydride (TFAA) in the presence of trifluoroacetic acid (TFA) in CH 2 Cl 2 solution at room temperature. Under these conditions, the added ferrocene underwent smooth acylation to give 1a in reproducible and satisfactory yield (52%, Scheme 1).…”

Trifluoromethanesulfonic Acid as Acylation Catalyst: Special Feature for C- and/or O-Acylation Reactions

“…Therefore, TfOH is needed in order to accelerate the acylation. Furthermore, the TfOH/TFAA catalytic system can also be applied to a vast number of acylation, such as the acylation of metallocenes with alkynoic acids which results in an acylated product that can undergo the impressive azide-alkyne "click" chemistry [34]. 2 [27] TfOH (1 equiv.…”

Synthesis, electrochemistry and IR spectroelectrochemistry of bisferrocenyl bridged benzene derivates

“…Oxalyl chloride (2.4 mL, 27.62 mmol) was added via syringe against a positive stream of nitrogen. After all gas evolution had ceased, the deep red solution was stirred for 30 min at room temperature [13]. All volatile components were distilled off under reduced pressure to leave a reddish material which was dried under reduced pressure at room temperature for 30 min.…”