In this study, the friction of eight kinds of poly(vinyl alcohol) hydrogel (PVA-H) samples has been studied under various load and velocity conditions to elucidate the effects of PVA factors such as the degree of polymerization (DP) and the saponification value (SV) on the tribological behavior of PVA-H. Results showed the variations of the friction properties due to the PVA factors in the two friction conditions found for the hydrogels: elastic friction and hydrodynamic lubrication. In the elastic friction, the larger frictions were induced by the higher values of DP and SV. In the hydrodynamic lubrication, on the other hand, PVA-Hs with lower SV showed larger friction. The results can then be used to adjust the parameters of PVA-H in order to get given friction properties, for instance for the friction between catheter or scalpel and PVA-H, which can be used as a biomodel material of artery or oral mucosa, for the training of surgeons.