FRI0488 Prevalence and Clinical Significance of Cognitive Impairment in Systemic Sclerosis

Abstract

Scientific AbstractsFriday, 12 June 2015 605Finally, in SSc patients LVEF inversely correlated with disease duration (R=-0.3, p=0.035) and number of ventricular ectopic beats (VEBs) on 24h-ECG Holter (R=-0.3, p=0.04). Interestingly, considering the right ventricle, the number of VEBs inversely correlated also with EF (R=-0.4, p=0.04) and directly correlated with EDV (R=0.4, p=0.01) and ESV (R=0.5, p=0.002). Conclusions: CMRI could be a useful tool to detect abnormal ventricular function and volumes and allows to identify cardiac abnormalities (T2 hyperintensity and LGE) in a subgroup of scleroderma patients. Even though the correlations between EF, end-systolic and diastolic volumes of both ventricles and some clinical characteristics (disease duration and number of VEBs) suggest a possible clinical significance of CMRI abnormalities, their real clinical value need to be further investigated.

Perceived Cognitive Function in People With Systemic Sclerosis: Associations With Symptoms and Daily Life Functioning

“…More than half (56%) of participants experienced mild‐to‐severe cognitive impairment in our study. Contrary to previous research (24), we found that older age was significantly associated with better perceived cognitive function. Because older participants were mostly retired, their daily life tasks might not require much cognitive capability compared with working‐age participants.…”

“…Perceived cognitive dysfunction in patients with SSc is prevalent (21,22,24,25); however, this domain is not well understood. This study is among the first to examine how demographic characteristics, SSc characteristics, and symptoms experienced relate to perceived cognitive function in people with SSc.…”

“…The analysis was controlled for demographic and SSc characteristics that previous literature associated with cognitive function. Specifically, we controlled for age (24), work status (27), SSc subtype (25), and disease duration (22,25).…”

“…Perceived cognitive dysfunction is among the most bothersome symptoms in patients who have SSc (23). Up to 87% of individuals with SSc have cognitive impairment that often affects memory and executive function (24,25). Although research suggests an association between dementia and SSc (26), the factors underlying cognitive impairment in patients with SSc remain unclear.…”