Evaluation of cognitive function in systemic sclerosis patients: a pilot study

Khedr, Eman M.; Fetoh, Noha Abo El; Gamal, Rania M.; Elzohri, Mona H.; Azoz, Nashwa Mostafa A.; Fürst, Daniel E.

doi:10.1007/s10067-019-04884-9

Cited by 12 publications

(11 citation statements)

References 38 publications

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“…A recent study formally assessed cognitive function in a cohort of SSc cases found evidence of cognitive impairment compared with matched healthy controls and that this associated with worse vascular disease. Future studies may explore whether this relates to comorbidity or is a specific feature of SSc [48].…”

Section: Cognitive Impairment In Sscmentioning

confidence: 99%

Cognitive dysfunction in autoimmune rheumatic diseases

Oláh¹,

Schwartz

Denton

et al. 2020

Arthritis Res Ther

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For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.

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Section: Cognitive Impairment In Sscmentioning

confidence: 99%

Cognitive dysfunction in autoimmune rheumatic diseases

Oláh¹,

Schwartz

Denton

et al. 2020

Arthritis Res Ther

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“…The grand-average peak amplitudes and latencies of the three components were calculated separately at F3, Fz, F4, C3, Cz, C4, P3, Pz, and P4. These areas are the ones usually activated by the stimuli (Choo et al, 2005;Verweij et al, 2014;Jin et al, 2015;Lei et al, 2015;Feng et al, 2019;Ueda and Nakao, 2019;Wang et al, 2019;Khedr et al, 2020).…”

Section: Erp Preprocessingmentioning

confidence: 99%

“…P300 is the largest positive-going peak amplitude of the waveform within a time window of 300-400 ms and is considered to represent the allocation of attentional resources to rare salient stimuli (Cote et al, 2001;Marhöfer et al, 2015). P300 amplitude and latency are thought to reflect cognitive processing, such as stimulus identification and evaluation (Feng et al, 2019;Wang et al, 2019;Gao et al, 2020;Khedr et al, 2020). Studies have also suggested that higher-order cognitive stimulielicited P300 components are generated from the anterior cortex, and these components reflect the response inhibition process (de Bruijn et al, 2020;Paul et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Chen

Zhang

Yang

et al. 2020

Front. Behav. Neurosci.

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Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD. Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design. Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD. Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual's arousal level and accelerated response-related decisions, while subjects' higher-level recognition had limited improvement with prolonged awareness.

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“…The behavioral data and latency and amplitude of N2 and P3 amplitude will be used to evaluate the effect of sleep deprivation and the intervention effect of acupuncture. ERP component detection, such as N2 and P3, has been used for the measurement of brain activity (13) and as a reflection of brain executive function (30)(31)(32)(33)(34)(35)(36)(37). The behavioral outcome variables include the mean RT for correct hits, hit rates (correct button presses for Go stimuli), and the percentage of false alarms (FAs, incorrect button presses in response to No-Go stimuli), which are used as indices of individual behavior performance.…”

Section: Secondary Outcomesmentioning

confidence: 99%

“…There have been several reports supporting the hypothesis that the visual N2 reflects a frontal inhibition mechanism (30,31), including cognitive control and response inhibition (32,33). Furthermore, recent studies suggest that P3 may play an important role in the post-response stage, reflecting processes of cognitive processing, such as stimulus identification and evaluation (34,35) or monitoring of inhibition (36,37).…”

Section: Introductionmentioning

confidence: 97%

Clinical Effect of Electroacupuncture on Acute Sleep Deprivation and Event-Related Potential Affecting the Inhibition Control of the Brain: Study Protocol for a Randomized Controlled Trial

Wang

Wu³

et al. 2022

Front. Neurol.

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BackgroundAcute sleep deprivation (ASD) can effect mood, attention, memory, alertness and metabolism. Especially, it is often accompanied by cognitive impairment of the brain. Acupuncture is safe and effective for improving cognitive function, but its underlying mechanism is not fully understood. In this study, an event-related potential (ERP) technique will be employed to measure the behavioral, cognitive, and physiological changes produced by electroacupuncture intervention after ASD.MethodsWe will recruit 60 healthy subjects. The participants will be randomly divided into a treatment group, a control group, a sham electroacupuncture group and a blank group, at a 1:1:1:1 ratio. The primary outcome will be determined by the change from baseline to 36 h in the MoCA score. The secondary results include the amplitude and latency of ERP N2 and P3, Go-hit rates, Go-RTs, No-Go-FA rates, the WCST, the Digit Span Subtest of the WAIS, the ESS score and FS-14. The 15 healthy subjects will not receive acupuncture treatment and ASD, but will receive EEG records and cognition functions test at the beginning and end of the experiment. Electroacupuncture intervention will be performed for 30 min once every 12 h, a total of three times. ERP measurements and other tests will be performed after baseline and ASD, and the statistician and outcome evaluator will be blinded to treatment allocation.DiscussionThis study is expected to investigate the effectiveness of electroacupuncture in improving cognition for ASD.Trial RegistrationChiCTR2200055999.

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Evaluation of cognitive function in systemic sclerosis patients: a pilot study

Cited by 12 publications

References 38 publications

Cognitive dysfunction in autoimmune rheumatic diseases

Cognitive dysfunction in autoimmune rheumatic diseases

Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation

Clinical Effect of Electroacupuncture on Acute Sleep Deprivation and Event-Related Potential Affecting the Inhibition Control of the Brain: Study Protocol for a Randomized Controlled Trial

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