Fresh frozen plasma quality: relation to age and gender of blood donors

Madla, W.; Alt, T.; Jungk, H.; Bux, Jürgen

doi:10.1111/j.1423-0410.2011.01518.x

Cited by 15 publications

(12 citation statements)

References 43 publications

(61 reference statements)

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“…ADAMTS13 level is higher in females than in males in a Japanese population (Kokame et al, 2011), which is similar to our results. Consistent with our results, gender-related differences in FVIII (Favaloro et al, 2005; Kadir et al, 1999; Madla et al, 2012), Fbg (Madla et al, 2012), and VWF (Favaloro et al, 2005; Kadir et al, 1999) were not observed. However, Conlan et al (1993) reported that FVIII and VWF levels are significantly higher in females than in males.…”

Section: Discussionsupporting

confidence: 92%

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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BackgroundABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with thrombospondin type 1 motif, 13). We investigated the effects of ABO type, age, and gender on plasma levels of FVIII, Fbg, VWF, and ADAMTS13 in a Chinese population.MethodsA total of 290 healthy volunteers were eligible for this study. ABO blood group was determined by indirect technique. FVIII:C and Fbg were measured by clotting assays. VWF antigen (VWF:Ag), collagen-binding activity (VWF:CBA), and ADAMTS13 antigen were assessed by ELISA, whereas VWF ristocetin cofactor activity (VWF:Rcof) was performed by agglutination of platelets with ristocetin.ResultsMean FVIII:C and VWF levels (VWF:Ag, VWF:CBA, and VWF:Rcof) were significantly higher in non-O than in O type subjects (p < 0.05 for all comparison). ADAMTS13 antigen decreased with increasing age, whereas the other parameters increased. Other than ADAMTS13 (p < 0.01), no gender-related variations were observed in the other parameters. Moreover, FVIII:C, Fbg, VWF:Ag, VWF:CBA, and VWF:Rcof showed significant and positive relationships with age (r = 0.421, 0.445, 0.410, 0.401, and 0.589, resp.; all p < 0.001), whereas a negative relationship was observed for ADAMTS13 antigen (r = 0.306; p = 0.006). Furthermore, FVIII:C were strongly correlated with VWF:Ag, VWF:CBA, and VWF:Rcof (r = 0.746, r = 0.746, and r = 0.576, resp.; p < 0.0001). VWF parameters were also strongly correlated with each other (r = 0.0.847 for VWF:Ag and VWF:CBA; r = 0.722 for VWF:Ag and VWF:Rcof; p < 0.0001).ConclusionsABO blood group, age, and gender showed different effects on plasma levels of FVIII:C, Fbg, VWF:Ag, VWF:CBA, VWF:Rcof, and ADAMTS13 antigen. These new data on a Chinese population are quite helpful to compare with other ethnic groups.

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Section: Discussionsupporting

confidence: 92%

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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“…The influence of senescence of hematopoietic stem cells on the quality of donated blood was not in the focus of the study and deserves further studies. However, recently published data could not detect an influence of the age of donors on the quality of stored red blood cells [17] and no clinically relevant changes in fresh frozen plasma [18]. A reduced hematopoietic regenerative capacity in aged donors should be recognized by the regular determination of the donor's hemoglobin value before each donation.…”

Section: Discussionmentioning

confidence: 99%

Blood Donation by Elderly Repeat Blood Donors

Zeiler

Lander-Kox

Alt

2014

Transfus Med Hemother

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Background: Upper age limits for blood donors are intended to protect elderly blood donors from donor reactions. However, due to a lack of data about adverse reactions in elderly blood donors, upper age limits are arbitrary and vary considerably between different countries. Methods: Here we present data from 171,231 voluntary repeat whole blood donors beyond the age of 68 years. Results: Blood donations from repeat blood donors beyond the age of 68 years increased from 2,114 in 2005 to 38,432 in 2012 (from 0,2% to 4.2% of all whole blood donations). Adverse donor reactions in repeat donors decreased with age and were lower than in the whole group (0.26%), even in donors older than 71 years (0.16%). However, from the age of 68 years, the time to complete recovery after donor reactions increased. Donor deferrals were highest in young blood donors (21.4%), but increased again in elderly blood donors beyond 71 years (12.6%). Conclusion: Blood donation by regular repeat blood donors older than 71 years may be safely continued. However, due to a lack of data for donors older than 75 years, blood donation in these donors should be handled with great caution.

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“…However, it is not known whether this has implications for patient outcomes. A study of the quality of fresh frozen plasma also concluded that there were no concerns about older donors contributing to the production of therapeutic or fractionated plasma . Meanwhile, Bontekoe and colleagues conducted a study of platelet quality in a small sample of donors and concluded that while there was poorer in vitro quality in platelets from older donors, this was unlikely to impact blood bank practice, and clinical implications are not known.…”

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confidence: 99%